Gender-Specific Inverse Associations Between Beans Intake, Serum Urate Levels, and Hyperuricemia: A Cross-Sectional Analysis Based on the Henan Rural Cohort Study
Background and Aims: Beans are rich in purines, which are important substances that lead to elevated serum urate, especially exogenous purines. Few studies were conducted to assess the relationship between beans intake and serum urate or hyperuricemia, especially in rural people. The purpose of this...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2020.593599/full |
| _version_ | 1818562589159849984 |
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| author | Ningning Cui Xiaokang Dong Yuan Xue Wei Liao Xiaotian Liu Yuqian Li Jian Hou Wenqian Huo Linlin Li Zhenxing Mao Zhaohui Zheng Chongjian Wang |
| author_facet | Ningning Cui Xiaokang Dong Yuan Xue Wei Liao Xiaotian Liu Yuqian Li Jian Hou Wenqian Huo Linlin Li Zhenxing Mao Zhaohui Zheng Chongjian Wang |
| author_sort | Ningning Cui |
| collection | DOAJ |
| description | Background and Aims: Beans are rich in purines, which are important substances that lead to elevated serum urate, especially exogenous purines. Few studies were conducted to assess the relationship between beans intake and serum urate or hyperuricemia, especially in rural people. The purpose of this study was to validate the association by gender in the rural Chinese population.Methods: A total of 38,855 participants aged 18–79 years old were enrolled from the Henan Rural Cohort Study (Registration number: ChiCTR-OOC-15006699). Dietary data were collected using a validated food frequency questionnaire (FFQ). Linear regression models and logistic regression models were used to examine the associations between beans intake and serum urate levels or hyperuricemia. Restricted cubic spline regression was performed to display the dose–response relationship.Results: In multivariate-adjusted linear regression, an inverse correlation was found between beans intake and serum urate level (the highest quartile Q4 vs. the bottom quartile Q1) in both men (P = 0.008) and women (P < 0.001). Per 10-g increment in beans intake was associated with 0.30 μmol/L decreased concentration of serum urate in men and 0.71 μmol/L in women. The multivariate-adjusted odds ratios (ORs) of hyperuricemia were 0.83 (0.71, 0.97) in men and 0.73 (0.63, 0.84) in women (Q4 vs. Q1). Per 10-g increment in beans intake created a 1% decreased risk of hyperuricemia in men and 3% in women. The cubic spline suggested a risk reduction for hyperuricemia with increasing intake of beans.Conclusion: A higher beans intake was associated with a lower serum urate level and a reduced risk of hyperuricemia in both sexes, and the association was more pronounced in women. |
| first_indexed | 2024-12-14T01:05:44Z |
| format | Article |
| id | doaj.art-242bc274b9be44cf8f5c59eb1f56158b |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-14T01:05:44Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-242bc274b9be44cf8f5c59eb1f56158b2022-12-21T23:22:58ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-01-01710.3389/fnut.2020.593599593599Gender-Specific Inverse Associations Between Beans Intake, Serum Urate Levels, and Hyperuricemia: A Cross-Sectional Analysis Based on the Henan Rural Cohort StudyNingning Cui0Xiaokang Dong1Yuan Xue2Wei Liao3Xiaotian Liu4Yuqian Li5Jian Hou6Wenqian Huo7Linlin Li8Zhenxing Mao9Zhaohui Zheng10Chongjian Wang11Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaDepartment of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaBackground and Aims: Beans are rich in purines, which are important substances that lead to elevated serum urate, especially exogenous purines. Few studies were conducted to assess the relationship between beans intake and serum urate or hyperuricemia, especially in rural people. The purpose of this study was to validate the association by gender in the rural Chinese population.Methods: A total of 38,855 participants aged 18–79 years old were enrolled from the Henan Rural Cohort Study (Registration number: ChiCTR-OOC-15006699). Dietary data were collected using a validated food frequency questionnaire (FFQ). Linear regression models and logistic regression models were used to examine the associations between beans intake and serum urate levels or hyperuricemia. Restricted cubic spline regression was performed to display the dose–response relationship.Results: In multivariate-adjusted linear regression, an inverse correlation was found between beans intake and serum urate level (the highest quartile Q4 vs. the bottom quartile Q1) in both men (P = 0.008) and women (P < 0.001). Per 10-g increment in beans intake was associated with 0.30 μmol/L decreased concentration of serum urate in men and 0.71 μmol/L in women. The multivariate-adjusted odds ratios (ORs) of hyperuricemia were 0.83 (0.71, 0.97) in men and 0.73 (0.63, 0.84) in women (Q4 vs. Q1). Per 10-g increment in beans intake created a 1% decreased risk of hyperuricemia in men and 3% in women. The cubic spline suggested a risk reduction for hyperuricemia with increasing intake of beans.Conclusion: A higher beans intake was associated with a lower serum urate level and a reduced risk of hyperuricemia in both sexes, and the association was more pronounced in women.https://www.frontiersin.org/articles/10.3389/fnut.2020.593599/fullbeans intakeserum uratehyperuricemiarural populationgender-specific |
| spellingShingle | Ningning Cui Xiaokang Dong Yuan Xue Wei Liao Xiaotian Liu Yuqian Li Jian Hou Wenqian Huo Linlin Li Zhenxing Mao Zhaohui Zheng Chongjian Wang Gender-Specific Inverse Associations Between Beans Intake, Serum Urate Levels, and Hyperuricemia: A Cross-Sectional Analysis Based on the Henan Rural Cohort Study Frontiers in Nutrition beans intake serum urate hyperuricemia rural population gender-specific |
| title | Gender-Specific Inverse Associations Between Beans Intake, Serum Urate Levels, and Hyperuricemia: A Cross-Sectional Analysis Based on the Henan Rural Cohort Study |
| title_full | Gender-Specific Inverse Associations Between Beans Intake, Serum Urate Levels, and Hyperuricemia: A Cross-Sectional Analysis Based on the Henan Rural Cohort Study |
| title_fullStr | Gender-Specific Inverse Associations Between Beans Intake, Serum Urate Levels, and Hyperuricemia: A Cross-Sectional Analysis Based on the Henan Rural Cohort Study |
| title_full_unstemmed | Gender-Specific Inverse Associations Between Beans Intake, Serum Urate Levels, and Hyperuricemia: A Cross-Sectional Analysis Based on the Henan Rural Cohort Study |
| title_short | Gender-Specific Inverse Associations Between Beans Intake, Serum Urate Levels, and Hyperuricemia: A Cross-Sectional Analysis Based on the Henan Rural Cohort Study |
| title_sort | gender specific inverse associations between beans intake serum urate levels and hyperuricemia a cross sectional analysis based on the henan rural cohort study |
| topic | beans intake serum urate hyperuricemia rural population gender-specific |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2020.593599/full |
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