Use of atypical antipsychotics in the treatment of schizophrenia in the Brazilian National Health System: a cohort study, 2008-2017
Abstract Objective: to investigate sociodemographic and clinical characteristics of users of atypical antipsychotics receiving care via the Specialized Component of Pharmaceutical Assistance (Componente Especializado da Assistência Farmacêutica - CEAF), for the treatment of schizophrenia in Brazil...
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| Format: | Article |
| Language: | English |
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Ministério da Saúde do Brasil
2023-03-01
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| Series: | Epidemiologia e Serviços de Saúde |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-96222023000100308&lng=en&tlng=en |
| _version_ | 1797866689154514944 |
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| author | Izabela Fulone Marcus Tolentino Silva Luciane Cruz Lopes |
| author_facet | Izabela Fulone Marcus Tolentino Silva Luciane Cruz Lopes |
| author_sort | Izabela Fulone |
| collection | DOAJ |
| description | Abstract Objective: to investigate sociodemographic and clinical characteristics of users of atypical antipsychotics receiving care via the Specialized Component of Pharmaceutical Assistance (Componente Especializado da Assistência Farmacêutica - CEAF), for the treatment of schizophrenia in Brazil, between 2008 and 2017. Methods: this was a retrospective cohort study using records of the authorizations for high complexity procedures retrieved from the Outpatient Information System of the Brazilian National Health System, from all Brazilian states. Results: of the 759,654 users, 50.5% were female, from the Southeast region (60.2%), diagnosed with paranoid schizophrenia (77.6%); it could be seen a higher prevalence of the use of risperidone (63.3%) among children/adolescents; olanzapine (34.0%) in adults; and quetiapine (47.4%) in older adults; about 40% of children/adolescents were in off-label use of antipsychotics according to age; adherence to CEAF was high (82%), and abandonment within six months was 24%. Conclusion: the findings expand knowledge about the sociodemographic and clinical profile of users and highlight the practice of off-label use. |
| first_indexed | 2024-04-09T23:28:18Z |
| format | Article |
| id | doaj.art-242d11a0345e48ea9e99b5131971d9a6 |
| institution | Directory Open Access Journal |
| issn | 2237-9622 |
| language | English |
| last_indexed | 2024-04-09T23:28:18Z |
| publishDate | 2023-03-01 |
| publisher | Ministério da Saúde do Brasil |
| record_format | Article |
| series | Epidemiologia e Serviços de Saúde |
| spelling | doaj.art-242d11a0345e48ea9e99b5131971d9a62023-03-21T07:33:23ZengMinistério da Saúde do BrasilEpidemiologia e Serviços de Saúde2237-96222023-03-0132110.1590/s2237-96222023000300015Use of atypical antipsychotics in the treatment of schizophrenia in the Brazilian National Health System: a cohort study, 2008-2017Izabela Fulonehttps://orcid.org/0000-0002-3211-6951Marcus Tolentino Silvahttps://orcid.org/0000-0002-7186-9075Luciane Cruz Lopeshttps://orcid.org/0000-0002-3684-3275Abstract Objective: to investigate sociodemographic and clinical characteristics of users of atypical antipsychotics receiving care via the Specialized Component of Pharmaceutical Assistance (Componente Especializado da Assistência Farmacêutica - CEAF), for the treatment of schizophrenia in Brazil, between 2008 and 2017. Methods: this was a retrospective cohort study using records of the authorizations for high complexity procedures retrieved from the Outpatient Information System of the Brazilian National Health System, from all Brazilian states. Results: of the 759,654 users, 50.5% were female, from the Southeast region (60.2%), diagnosed with paranoid schizophrenia (77.6%); it could be seen a higher prevalence of the use of risperidone (63.3%) among children/adolescents; olanzapine (34.0%) in adults; and quetiapine (47.4%) in older adults; about 40% of children/adolescents were in off-label use of antipsychotics according to age; adherence to CEAF was high (82%), and abandonment within six months was 24%. Conclusion: the findings expand knowledge about the sociodemographic and clinical profile of users and highlight the practice of off-label use.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-96222023000100308&lng=en&tlng=enAntipsychoticsBrazilian National Health SystemSchizophreniaBrazilOff-Label UseCohort Studies |
| spellingShingle | Izabela Fulone Marcus Tolentino Silva Luciane Cruz Lopes Use of atypical antipsychotics in the treatment of schizophrenia in the Brazilian National Health System: a cohort study, 2008-2017 Epidemiologia e Serviços de Saúde Antipsychotics Brazilian National Health System Schizophrenia Brazil Off-Label Use Cohort Studies |
| title | Use of atypical antipsychotics in the treatment of schizophrenia in the Brazilian National Health System: a cohort study, 2008-2017 |
| title_full | Use of atypical antipsychotics in the treatment of schizophrenia in the Brazilian National Health System: a cohort study, 2008-2017 |
| title_fullStr | Use of atypical antipsychotics in the treatment of schizophrenia in the Brazilian National Health System: a cohort study, 2008-2017 |
| title_full_unstemmed | Use of atypical antipsychotics in the treatment of schizophrenia in the Brazilian National Health System: a cohort study, 2008-2017 |
| title_short | Use of atypical antipsychotics in the treatment of schizophrenia in the Brazilian National Health System: a cohort study, 2008-2017 |
| title_sort | use of atypical antipsychotics in the treatment of schizophrenia in the brazilian national health system a cohort study 2008 2017 |
| topic | Antipsychotics Brazilian National Health System Schizophrenia Brazil Off-Label Use Cohort Studies |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-96222023000100308&lng=en&tlng=en |
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