Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers

Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers

Chromosome segregation during mitosis depends upon Kinesin-5 motors, which display a conserved, bipolar homotetrameric organization consisting of two motor dimers at opposite ends of a central rod. Kinesin-5 motors crosslink adjacent microtubules to drive or constrain their sliding apart, but the st...

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Bibliographic Details
Main Authors: Jessica E Scholey, Stanley Nithianantham, Jonathan M Scholey, Jawdat Al-Bassam
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-04-01
Series:eLife
Subjects:
mitosis
Kinesin-5
microtubule
motor protein
coiled-coil
X-ray structure
Online Access:https://elifesciences.org/articles/02217

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