Uneven Meibomian Gland Dropout in Patients with Meibomian Gland Dysfunction and <i>Demodex</i> Infestation
The purpose of this study was to compare the differences between uneven meibomian gland (MG) atrophy with and without <i>Demodex</i> infestation based on the index of uneven atrophy score (UAS). In this retrospective cohort study, 158 subjects were recruited, including 66 subjects in the...
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/17/5085 |
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| author | Xinxin Yu Yana Fu Hengli Lian Dandan Wang Zuhui Zhang Qi Dai |
| author_facet | Xinxin Yu Yana Fu Hengli Lian Dandan Wang Zuhui Zhang Qi Dai |
| author_sort | Xinxin Yu |
| collection | DOAJ |
| description | The purpose of this study was to compare the differences between uneven meibomian gland (MG) atrophy with and without <i>Demodex</i> infestation based on the index of uneven atrophy score (UAS). In this retrospective cohort study, 158 subjects were recruited, including 66 subjects in the <i>Demodex</i>-positive MGD group, 49 subjects in the <i>Demodex</i>-negative MGD group, and 43 subjects as normal control. No significant difference was verified in OSDI, TMH, TBUT, CFS, lid margin score, and meibograde (all <i>p</i> > 0.05) between the <i>Demodex</i>-positive MGD group and the <i>Demodex</i>-negative MGD group. The UAS index of the upper eyelid or both eyelids was significantly higher in the <i>Demodex</i>-positive group in comparison with the normal control group and <i>Demodex</i>-negative group and the difference was statistically significant between the three groups. The UAS was significantly positive correlation with OSDI (r = 0.209, <i>p</i> < 0.05), lid margin score (r = 0.287, <i>p</i> < 0.001), and meibograde (r = 0.356, <i>p</i> < 0.001), which has a significant negative correlation with TBUT (r = −0.248, <i>p</i> < 0.05). Thus, <i>Demodex</i> infestation can cause uneven MG atrophy and we propose a novel index of UAS, which is used to evaluate uneven atrophy of MGs and as a morphological index of Demodex infestation. |
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| language | English |
| last_indexed | 2024-03-10T01:39:07Z |
| publishDate | 2022-08-01 |
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| spelling | doaj.art-242e97495a344f4d8930ddb70b4dcdc52023-11-23T13:27:22ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011117508510.3390/jcm11175085Uneven Meibomian Gland Dropout in Patients with Meibomian Gland Dysfunction and <i>Demodex</i> InfestationXinxin Yu0Yana Fu1Hengli Lian2Dandan Wang3Zuhui Zhang4Qi Dai5School of Optometry and Ophthalmology, The Eye Hospital of Wenzhou Medical University, Wenzhou 325027, ChinaSchool of Optometry and Ophthalmology, The Eye Hospital of Wenzhou Medical University, Wenzhou 325027, ChinaSchool of Optometry and Ophthalmology, The Eye Hospital of Wenzhou Medical University, Wenzhou 325027, ChinaSchool of Optometry and Ophthalmology, The Eye Hospital of Wenzhou Medical University, Wenzhou 325027, ChinaSchool of Optometry and Ophthalmology, The Eye Hospital of Wenzhou Medical University, Wenzhou 325027, ChinaSchool of Optometry and Ophthalmology, The Eye Hospital of Wenzhou Medical University, Wenzhou 325027, ChinaThe purpose of this study was to compare the differences between uneven meibomian gland (MG) atrophy with and without <i>Demodex</i> infestation based on the index of uneven atrophy score (UAS). In this retrospective cohort study, 158 subjects were recruited, including 66 subjects in the <i>Demodex</i>-positive MGD group, 49 subjects in the <i>Demodex</i>-negative MGD group, and 43 subjects as normal control. No significant difference was verified in OSDI, TMH, TBUT, CFS, lid margin score, and meibograde (all <i>p</i> > 0.05) between the <i>Demodex</i>-positive MGD group and the <i>Demodex</i>-negative MGD group. The UAS index of the upper eyelid or both eyelids was significantly higher in the <i>Demodex</i>-positive group in comparison with the normal control group and <i>Demodex</i>-negative group and the difference was statistically significant between the three groups. The UAS was significantly positive correlation with OSDI (r = 0.209, <i>p</i> < 0.05), lid margin score (r = 0.287, <i>p</i> < 0.001), and meibograde (r = 0.356, <i>p</i> < 0.001), which has a significant negative correlation with TBUT (r = −0.248, <i>p</i> < 0.05). Thus, <i>Demodex</i> infestation can cause uneven MG atrophy and we propose a novel index of UAS, which is used to evaluate uneven atrophy of MGs and as a morphological index of Demodex infestation.https://www.mdpi.com/2077-0383/11/17/5085meibomian gland dysfunction<i>Demodex</i> infestationuneven atrophy score |
| spellingShingle | Xinxin Yu Yana Fu Hengli Lian Dandan Wang Zuhui Zhang Qi Dai Uneven Meibomian Gland Dropout in Patients with Meibomian Gland Dysfunction and <i>Demodex</i> Infestation Journal of Clinical Medicine meibomian gland dysfunction <i>Demodex</i> infestation uneven atrophy score |
| title | Uneven Meibomian Gland Dropout in Patients with Meibomian Gland Dysfunction and <i>Demodex</i> Infestation |
| title_full | Uneven Meibomian Gland Dropout in Patients with Meibomian Gland Dysfunction and <i>Demodex</i> Infestation |
| title_fullStr | Uneven Meibomian Gland Dropout in Patients with Meibomian Gland Dysfunction and <i>Demodex</i> Infestation |
| title_full_unstemmed | Uneven Meibomian Gland Dropout in Patients with Meibomian Gland Dysfunction and <i>Demodex</i> Infestation |
| title_short | Uneven Meibomian Gland Dropout in Patients with Meibomian Gland Dysfunction and <i>Demodex</i> Infestation |
| title_sort | uneven meibomian gland dropout in patients with meibomian gland dysfunction and i demodex i infestation |
| topic | meibomian gland dysfunction <i>Demodex</i> infestation uneven atrophy score |
| url | https://www.mdpi.com/2077-0383/11/17/5085 |
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