Clinical-epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with Guillain-Barré syndrome in a national third-level hospital, Lima, Peru
ABSTRACT Background: Guillain-Barré syndrome (GBS) is an autoimmune disease that affects the peripheral nervous system. Severe motor deficit (SMD), respiratory impairment, cranial nerve involvement and autonomic dysfunction are associated with a poor prognosis. Objective: To investigate the associ...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2021-09-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000800697&tlng=en |
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| author | Victor Velásquez-Rimachi Angélica Verónica López-Saavedra Ethel Rodriguez-López Hillary Elguera-Huaman Kelly Meza Carlos Alva-Díaz Kevin Pacheco-Barrios |
| author_facet | Victor Velásquez-Rimachi Angélica Verónica López-Saavedra Ethel Rodriguez-López Hillary Elguera-Huaman Kelly Meza Carlos Alva-Díaz Kevin Pacheco-Barrios |
| author_sort | Victor Velásquez-Rimachi |
| collection | DOAJ |
| description | ABSTRACT Background: Guillain-Barré syndrome (GBS) is an autoimmune disease that affects the peripheral nervous system. Severe motor deficit (SMD), respiratory impairment, cranial nerve involvement and autonomic dysfunction are associated with a poor prognosis. Objective: To investigate the association between the clinical-epidemiological characteristics and the discharge results among Peruvian patients with GBS. Methods: We carried out a retrospective observational study on patients with GBS who survived until discharge. We used the Brighton Collaboration’s criteria and considered Hughes Severity Scale (HSS) scores greater than two to be SMD. We defined the discharge results as an improvement if the HSS score decreased by at least one point from admission to hospital discharge and defined hospital stay as prolonged if > 14 days. Results: We analyzed 92 patients, among whom 70.7% were male. Quadriparesis (81.1%) and hyporeflexia (86.8%) were the most characteristic manifestations. We observed that more than half of the cases were in summer and winter. Gastrointestinal infections were associated with a higher proportion of prolonged stays. The proportion of improvement was lower among patients who had an SMD at hospital admission. We confirmed these results through fitting in multivariate models. Conclusions: The prolonged stay was related to previous gastrointestinal infection, while a less improvement in SMD individuals at admission. Prospective multicenter surveillance systems are needed for monitoring GBS cases in low-income settings like Peru. |
| first_indexed | 2024-12-23T19:36:28Z |
| format | Article |
| id | doaj.art-2430fdaa62bc4a7ba2748bca8ce40ca6 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-23T19:36:28Z |
| publishDate | 2021-09-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-2430fdaa62bc4a7ba2748bca8ce40ca62022-12-21T17:33:46ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272021-09-0179869770410.1590/0004-282x-anp-2020-0154Clinical-epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with Guillain-Barré syndrome in a national third-level hospital, Lima, PeruVictor Velásquez-Rimachihttps://orcid.org/0000-0002-9350-7171Angélica Verónica López-Saavedrahttps://orcid.org/0000-0002-5235-9117Ethel Rodriguez-Lópezhttps://orcid.org/0000-0003-4842-9116Hillary Elguera-Huamanhttps://orcid.org/0000-0003-0887-6093Kelly Mezahttps://orcid.org/0000-0002-1777-2360Carlos Alva-Díazhttps://orcid.org/0000-0003-3584-7298Kevin Pacheco-Barrioshttps://orcid.org/0000-0002-7166-2816ABSTRACT Background: Guillain-Barré syndrome (GBS) is an autoimmune disease that affects the peripheral nervous system. Severe motor deficit (SMD), respiratory impairment, cranial nerve involvement and autonomic dysfunction are associated with a poor prognosis. Objective: To investigate the association between the clinical-epidemiological characteristics and the discharge results among Peruvian patients with GBS. Methods: We carried out a retrospective observational study on patients with GBS who survived until discharge. We used the Brighton Collaboration’s criteria and considered Hughes Severity Scale (HSS) scores greater than two to be SMD. We defined the discharge results as an improvement if the HSS score decreased by at least one point from admission to hospital discharge and defined hospital stay as prolonged if > 14 days. Results: We analyzed 92 patients, among whom 70.7% were male. Quadriparesis (81.1%) and hyporeflexia (86.8%) were the most characteristic manifestations. We observed that more than half of the cases were in summer and winter. Gastrointestinal infections were associated with a higher proportion of prolonged stays. The proportion of improvement was lower among patients who had an SMD at hospital admission. We confirmed these results through fitting in multivariate models. Conclusions: The prolonged stay was related to previous gastrointestinal infection, while a less improvement in SMD individuals at admission. Prospective multicenter surveillance systems are needed for monitoring GBS cases in low-income settings like Peru.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000800697&tlng=enGuillain-Barré SyndromeSeasonsPeripheral Nervous System |
| spellingShingle | Victor Velásquez-Rimachi Angélica Verónica López-Saavedra Ethel Rodriguez-López Hillary Elguera-Huaman Kelly Meza Carlos Alva-Díaz Kevin Pacheco-Barrios Clinical-epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with Guillain-Barré syndrome in a national third-level hospital, Lima, Peru Arquivos de Neuro-Psiquiatria Guillain-Barré Syndrome Seasons Peripheral Nervous System |
| title | Clinical-epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with Guillain-Barré syndrome in a national third-level hospital, Lima, Peru |
| title_full | Clinical-epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with Guillain-Barré syndrome in a national third-level hospital, Lima, Peru |
| title_fullStr | Clinical-epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with Guillain-Barré syndrome in a national third-level hospital, Lima, Peru |
| title_full_unstemmed | Clinical-epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with Guillain-Barré syndrome in a national third-level hospital, Lima, Peru |
| title_short | Clinical-epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with Guillain-Barré syndrome in a national third-level hospital, Lima, Peru |
| title_sort | clinical epidemiological characteristics associated with discharge outcomes and seasonality among surviving patients with guillain barre syndrome in a national third level hospital lima peru |
| topic | Guillain-Barré Syndrome Seasons Peripheral Nervous System |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000800697&tlng=en |
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