Implications of Persistent HPV52 and HPV58 Positivity for the Management of Cervical Lesions
ObjectiveThis study aimed to compare the variability of HPV16/18/52/58 subtype infections in patients with different cervical lesions, to explore the guiding significance of persistent positive HPV subtypes 52 and 58 in the stratified management of cervical lesions, and to determine the appropriate...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.812076/full |
| _version_ | 1811247357386293248 |
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| author | Baozhu Yi Qian Xu Zhixuan Zhang Jinyi Zhang Yi Xu Luoqi Huang Yue Hu Quanmei Tu Jingyun Chen |
| author_facet | Baozhu Yi Qian Xu Zhixuan Zhang Jinyi Zhang Yi Xu Luoqi Huang Yue Hu Quanmei Tu Jingyun Chen |
| author_sort | Baozhu Yi |
| collection | DOAJ |
| description | ObjectiveThis study aimed to compare the variability of HPV16/18/52/58 subtype infections in patients with different cervical lesions, to explore the guiding significance of persistent positive HPV subtypes 52 and 58 in the stratified management of cervical lesions, and to determine the appropriate management model.MethodThis study was conducted through a retrospective analysis of 244,218 patients who underwent HPV testing at the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University from September 2014 to December 2020 to examine the distribution of different types of HPV infection. From March 2015 to September 2017, 3,014 patients with known HPV underwent colposcopy to analyze high-risk HPV infection for different cervical lesions. Meanwhile, from September 2014 to December 2020, 1,616 patients positive for HPV16/18/52/58 alone with normal TCT who underwent colposcopy in our hospital were retrospectively analyzed for the occurrence of cervical and vulvovaginal lesions, with colposcopic biopsy pathology results serving as the gold standard for statistical analysis.ResultAnalysis of 244,218 patients who had HPV tested revealed that the top 3 high-risk HPV types were HPV52, HPV58, and HPV16. Further analysis of 3,014 patients showed that 78.04% of patients referred for colposcopy had HPV16/18/52/58 alone. Among high-grade squamous intraepithelial lesions (HSIL) and cervical cancer, the most common is HPV16, followed by HPV58 and then HPV52 (p < 0.05). A total of 1,616 patients with normal TCT who were referred for colposcopy due to HPV16/18/52/58 infection were further analyzed. Based on pathological findings in lesions of HSIL and CC, HPV16 is the most common, followed by HPV58 and then HPV18 (p < 0.05). In the 1,616 patients analyzed, high-grade vulvovaginal lesions were detected, with HPV58 being the most common, followed by HPV16 and then HPV52 (p < 0.05).Conclusion1. In patients with positive HPV58 alone and normal TCT, the indications for colposcopy may be relaxed, with particular attention paid to the possibility of vulvar and vaginal lesions.2. Patients with a positive HPV type 52 alone and normal TCT may be considered for a follow-up review and, if necessary, a colposcopy.3. The development of a more suitable HPV vaccine for the Asian population, such as HPV16/18/52/58, may better protect women’s health. |
| first_indexed | 2024-04-12T15:07:23Z |
| format | Article |
| id | doaj.art-24333f716b6d4c739018b2b0ee077da7 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T15:07:23Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-24333f716b6d4c739018b2b0ee077da72022-12-22T03:27:52ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-05-011210.3389/fonc.2022.812076812076Implications of Persistent HPV52 and HPV58 Positivity for the Management of Cervical LesionsBaozhu Yi0Qian Xu1Zhixuan Zhang2Jinyi Zhang3Yi Xu4Luoqi Huang5Yue Hu6Quanmei Tu7Jingyun Chen8Department of Gynecology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Gynecology, Yiwu Maternity and Children Health Care Hospital, Jinhua, ChinaDepartment of Gynecology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Gynecology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Gynecology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Gynecology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Gynecology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Gynecology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Gynecology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, ChinaObjectiveThis study aimed to compare the variability of HPV16/18/52/58 subtype infections in patients with different cervical lesions, to explore the guiding significance of persistent positive HPV subtypes 52 and 58 in the stratified management of cervical lesions, and to determine the appropriate management model.MethodThis study was conducted through a retrospective analysis of 244,218 patients who underwent HPV testing at the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University from September 2014 to December 2020 to examine the distribution of different types of HPV infection. From March 2015 to September 2017, 3,014 patients with known HPV underwent colposcopy to analyze high-risk HPV infection for different cervical lesions. Meanwhile, from September 2014 to December 2020, 1,616 patients positive for HPV16/18/52/58 alone with normal TCT who underwent colposcopy in our hospital were retrospectively analyzed for the occurrence of cervical and vulvovaginal lesions, with colposcopic biopsy pathology results serving as the gold standard for statistical analysis.ResultAnalysis of 244,218 patients who had HPV tested revealed that the top 3 high-risk HPV types were HPV52, HPV58, and HPV16. Further analysis of 3,014 patients showed that 78.04% of patients referred for colposcopy had HPV16/18/52/58 alone. Among high-grade squamous intraepithelial lesions (HSIL) and cervical cancer, the most common is HPV16, followed by HPV58 and then HPV52 (p < 0.05). A total of 1,616 patients with normal TCT who were referred for colposcopy due to HPV16/18/52/58 infection were further analyzed. Based on pathological findings in lesions of HSIL and CC, HPV16 is the most common, followed by HPV58 and then HPV18 (p < 0.05). In the 1,616 patients analyzed, high-grade vulvovaginal lesions were detected, with HPV58 being the most common, followed by HPV16 and then HPV52 (p < 0.05).Conclusion1. In patients with positive HPV58 alone and normal TCT, the indications for colposcopy may be relaxed, with particular attention paid to the possibility of vulvar and vaginal lesions.2. Patients with a positive HPV type 52 alone and normal TCT may be considered for a follow-up review and, if necessary, a colposcopy.3. The development of a more suitable HPV vaccine for the Asian population, such as HPV16/18/52/58, may better protect women’s health.https://www.frontiersin.org/articles/10.3389/fonc.2022.812076/fullcervical lesionshuman papillomavirus (HPV)colposcopic biopsyhuman papillomavirus 52 (HPV52)human papillomavirus 58cervical cancer |
| spellingShingle | Baozhu Yi Qian Xu Zhixuan Zhang Jinyi Zhang Yi Xu Luoqi Huang Yue Hu Quanmei Tu Jingyun Chen Implications of Persistent HPV52 and HPV58 Positivity for the Management of Cervical Lesions Frontiers in Oncology cervical lesions human papillomavirus (HPV) colposcopic biopsy human papillomavirus 52 (HPV52) human papillomavirus 58 cervical cancer |
| title | Implications of Persistent HPV52 and HPV58 Positivity for the Management of Cervical Lesions |
| title_full | Implications of Persistent HPV52 and HPV58 Positivity for the Management of Cervical Lesions |
| title_fullStr | Implications of Persistent HPV52 and HPV58 Positivity for the Management of Cervical Lesions |
| title_full_unstemmed | Implications of Persistent HPV52 and HPV58 Positivity for the Management of Cervical Lesions |
| title_short | Implications of Persistent HPV52 and HPV58 Positivity for the Management of Cervical Lesions |
| title_sort | implications of persistent hpv52 and hpv58 positivity for the management of cervical lesions |
| topic | cervical lesions human papillomavirus (HPV) colposcopic biopsy human papillomavirus 52 (HPV52) human papillomavirus 58 cervical cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.812076/full |
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