Risk factors for nonalcoholic steatohepatitis in cryptogenic cirrhosis
CONTEXT: In about 10% of patients with chronic liver disease, it is not possible to identify an etiologic factor. These cases are called cryptogenic cirrhosis. Currently, nonalcoholic steatohepatitis (NASH) is being considered as a possible etiologic factor for a significant segment of patients that...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
2012-12-01
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| Series: | Arquivos de Gastroenterologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032012000400003&lng=en&tlng=en |
| _version_ | 1818215099690647552 |
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| author | Andrea Benevides Leite Angelo Alves de Mattos Angelo Zambam de Mattos Gabriela Perdomo Coral Sandro Evaldt |
| author_facet | Andrea Benevides Leite Angelo Alves de Mattos Angelo Zambam de Mattos Gabriela Perdomo Coral Sandro Evaldt |
| author_sort | Andrea Benevides Leite |
| collection | DOAJ |
| description | CONTEXT: In about 10% of patients with chronic liver disease, it is not possible to identify an etiologic factor. These cases are called cryptogenic cirrhosis. Currently, nonalcoholic steatohepatitis (NASH) is being considered as a possible etiologic factor for a significant segment of patients that presents with cryptogenic cirrhosis. OBJECTIVE: To estimate the prevalence of risk factors for NASH in patients with cryptogenic cirrhosis, in order to verify if there is a causal relationship between them. METHOD: Cross-sectional study, with evaluation of the demographic and laboratorial data of patients with cryptogenic cirrhosis. They were compared with data obtained from a group with NASH and a group with alcoholic and/or hepatitis C (HCV) cirrhosis. RESULTS: Forty seven patients with cryptogenic cirrhosis were evaluated, 47 with NASH and 196 with HCV and/or alcoholic cirrhosis. The mean age of patients with cryptogenic cirrhosis was 52 years, while in those with NASH it was 46.4 years (P = 0,041). The group with cryptogenic cirrhosis had 23 female and 24 male patients. Of the patients who presented with NASH, 68.1% were female. Of the patients who presented with alcoholic/HCV cirrhosis, 64.8% were male. There were no statistically significant differences between the groups. In cryptogenic cirrhosis patients, the following prevalences could be observed: impaired fasting glycemia - 68.2%; obesity - 27.5%; total hypercholesterolemia - 27.9%; low HDL levels - 58.1% (women - 81%; men - 36.4%); hypertriglyceridemia - 16.3%. The results seen in cryptogenic cirrhosis patients showed statistical similarity with the results of the NASH group regarding fasting glycemia (62.8%) and male HDL levels (53.8%). The comparison with the alcoholic/HCV cirrhosis group showed statistical differences regarding fasting glycemia (45.2%), hypercholesterolemia (13.3%) and female HDL levels (50.8%). CONCLUSIONS: It is not possible to establish a causal relationship between cryptogenic cirrhosis and NASH. Only data related to fasting glycemia and HDL levels in male patients showed statistical similarities between both groups of patients. |
| first_indexed | 2024-12-12T06:30:42Z |
| format | Article |
| id | doaj.art-24367fd42a8a4c3c8c0da3ece89aa4c5 |
| institution | Directory Open Access Journal |
| issn | 1678-4219 |
| language | English |
| last_indexed | 2024-12-12T06:30:42Z |
| publishDate | 2012-12-01 |
| publisher | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) |
| record_format | Article |
| series | Arquivos de Gastroenterologia |
| spelling | doaj.art-24367fd42a8a4c3c8c0da3ece89aa4c52022-12-22T00:34:35ZengInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)Arquivos de Gastroenterologia1678-42192012-12-0149424524910.1590/S0004-28032012000400003S0004-28032012000400003Risk factors for nonalcoholic steatohepatitis in cryptogenic cirrhosisAndrea Benevides Leite0Angelo Alves de Mattos1Angelo Zambam de Mattos2Gabriela Perdomo Coral3Sandro Evaldt4Universidade Federal de Ciências da Saúde de Porto AlegreUniversidade Federal de Ciências da Saúde de Porto AlegreUniversidade Federal de Ciências da Saúde de Porto AlegreUniversidade Federal de Ciências da Saúde de Porto AlegreUniversidade Federal de Ciências da Saúde de Porto AlegreCONTEXT: In about 10% of patients with chronic liver disease, it is not possible to identify an etiologic factor. These cases are called cryptogenic cirrhosis. Currently, nonalcoholic steatohepatitis (NASH) is being considered as a possible etiologic factor for a significant segment of patients that presents with cryptogenic cirrhosis. OBJECTIVE: To estimate the prevalence of risk factors for NASH in patients with cryptogenic cirrhosis, in order to verify if there is a causal relationship between them. METHOD: Cross-sectional study, with evaluation of the demographic and laboratorial data of patients with cryptogenic cirrhosis. They were compared with data obtained from a group with NASH and a group with alcoholic and/or hepatitis C (HCV) cirrhosis. RESULTS: Forty seven patients with cryptogenic cirrhosis were evaluated, 47 with NASH and 196 with HCV and/or alcoholic cirrhosis. The mean age of patients with cryptogenic cirrhosis was 52 years, while in those with NASH it was 46.4 years (P = 0,041). The group with cryptogenic cirrhosis had 23 female and 24 male patients. Of the patients who presented with NASH, 68.1% were female. Of the patients who presented with alcoholic/HCV cirrhosis, 64.8% were male. There were no statistically significant differences between the groups. In cryptogenic cirrhosis patients, the following prevalences could be observed: impaired fasting glycemia - 68.2%; obesity - 27.5%; total hypercholesterolemia - 27.9%; low HDL levels - 58.1% (women - 81%; men - 36.4%); hypertriglyceridemia - 16.3%. The results seen in cryptogenic cirrhosis patients showed statistical similarity with the results of the NASH group regarding fasting glycemia (62.8%) and male HDL levels (53.8%). The comparison with the alcoholic/HCV cirrhosis group showed statistical differences regarding fasting glycemia (45.2%), hypercholesterolemia (13.3%) and female HDL levels (50.8%). CONCLUSIONS: It is not possible to establish a causal relationship between cryptogenic cirrhosis and NASH. Only data related to fasting glycemia and HDL levels in male patients showed statistical similarities between both groups of patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032012000400003&lng=en&tlng=enCirrose hepáticaFígado gordurosoDoenças metabólicas |
| spellingShingle | Andrea Benevides Leite Angelo Alves de Mattos Angelo Zambam de Mattos Gabriela Perdomo Coral Sandro Evaldt Risk factors for nonalcoholic steatohepatitis in cryptogenic cirrhosis Arquivos de Gastroenterologia Cirrose hepática Fígado gorduroso Doenças metabólicas |
| title | Risk factors for nonalcoholic steatohepatitis in cryptogenic cirrhosis |
| title_full | Risk factors for nonalcoholic steatohepatitis in cryptogenic cirrhosis |
| title_fullStr | Risk factors for nonalcoholic steatohepatitis in cryptogenic cirrhosis |
| title_full_unstemmed | Risk factors for nonalcoholic steatohepatitis in cryptogenic cirrhosis |
| title_short | Risk factors for nonalcoholic steatohepatitis in cryptogenic cirrhosis |
| title_sort | risk factors for nonalcoholic steatohepatitis in cryptogenic cirrhosis |
| topic | Cirrose hepática Fígado gorduroso Doenças metabólicas |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032012000400003&lng=en&tlng=en |
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