Aberrant Gray Matter Structure Associated with Sleep Disturbance in the Drug Naïve Subjects with Alzheimer’s Disease
Background and Objective Although the sleep disturbances are very common and serious behavioral symptoms in Alzheimer’s disease (AD), the neuronal substrate of the gray matter structures associated with sleep disturbances in AD were not clear. The aim of this study is to investigate distinctive corr...
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Korean Society of Sleep Medicine
2014-12-01
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Series: | Sleep Medicine Research |
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Online Access: | http://www.sleepmedres.org/upload/pdf/smr-5-2-43.pdf |
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author | Hyun Kook Lim Won Sang Jung Jong-Hyun Jeong Ho-Jun Seo Tae-Won Kim Jin-Hee Han Chang Uk Lee Seung Chul Hong |
author_facet | Hyun Kook Lim Won Sang Jung Jong-Hyun Jeong Ho-Jun Seo Tae-Won Kim Jin-Hee Han Chang Uk Lee Seung Chul Hong |
author_sort | Hyun Kook Lim |
collection | DOAJ |
description | Background and Objective Although the sleep disturbances are very common and serious behavioral symptoms in Alzheimer’s disease (AD), the neuronal substrate of the gray matter structures associated with sleep disturbances in AD were not clear. The aim of this study is to investigate distinctive correlation patterns between the gray matter volume and sleep disturbances in AD. Methods Thirty drug-naïve patients with AD and 30 group-matched healthy control subjects underwent 3T magnetic resonance imaging scanning, and the whole brain gray matter volumes were measured using voxel based morphometry. We explored the correlation pattern between the gray matter volumes and the sleep disturbances in AD using the sleep disturbance subscale of Neuropsychiatric Inventory (NPI). Results Significant negative correlations were observed between left dorsolateral prefrontal cortex (DLPFC) and hypothalamus volumes and sleep disturbance subscale of NPI (false discovery rate corrected for multiple comparisons p < 0.05). Conclusions This study was the first to explore the relationships between whole brain gray matter volumes and sleep disturbances of drug-naïve patients with AD. These structural changes in DLPFC and hypothalamus might be the core of the underlying neurobiological mechanisms of sleep disturbances in AD. |
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institution | Directory Open Access Journal |
issn | 2093-9175 2233-8853 |
language | English |
last_indexed | 2024-04-13T04:04:10Z |
publishDate | 2014-12-01 |
publisher | Korean Society of Sleep Medicine |
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series | Sleep Medicine Research |
spelling | doaj.art-24381b40bde5471fa92cc54886c62eb72022-12-22T03:03:23ZengKorean Society of Sleep MedicineSleep Medicine Research2093-91752233-88532014-12-0152434810.17241/smr.2014.5.2.4351Aberrant Gray Matter Structure Associated with Sleep Disturbance in the Drug Naïve Subjects with Alzheimer’s DiseaseHyun Kook Lim0Won Sang Jung1Jong-Hyun Jeong2Ho-Jun Seo3Tae-Won Kim4Jin-Hee Han5Chang Uk Lee6Seung Chul Hong7 Departments of Psychiatry, College of Medicine, The Catholic University of Korea, Suwon, Korea Radiology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea Departments of Psychiatry, College of Medicine, The Catholic University of Korea, Suwon, Korea Departments of Psychiatry, College of Medicine, The Catholic University of Korea, Suwon, Korea Departments of Psychiatry, College of Medicine, The Catholic University of Korea, Suwon, Korea Departments of Psychiatry, College of Medicine, The Catholic University of Korea, Suwon, Korea Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Departments of Psychiatry, College of Medicine, The Catholic University of Korea, Suwon, KoreaBackground and Objective Although the sleep disturbances are very common and serious behavioral symptoms in Alzheimer’s disease (AD), the neuronal substrate of the gray matter structures associated with sleep disturbances in AD were not clear. The aim of this study is to investigate distinctive correlation patterns between the gray matter volume and sleep disturbances in AD. Methods Thirty drug-naïve patients with AD and 30 group-matched healthy control subjects underwent 3T magnetic resonance imaging scanning, and the whole brain gray matter volumes were measured using voxel based morphometry. We explored the correlation pattern between the gray matter volumes and the sleep disturbances in AD using the sleep disturbance subscale of Neuropsychiatric Inventory (NPI). Results Significant negative correlations were observed between left dorsolateral prefrontal cortex (DLPFC) and hypothalamus volumes and sleep disturbance subscale of NPI (false discovery rate corrected for multiple comparisons p < 0.05). Conclusions This study was the first to explore the relationships between whole brain gray matter volumes and sleep disturbances of drug-naïve patients with AD. These structural changes in DLPFC and hypothalamus might be the core of the underlying neurobiological mechanisms of sleep disturbances in AD.http://www.sleepmedres.org/upload/pdf/smr-5-2-43.pdfSleep disturbancesAlzheimer’s diseaseVoxel based morphometryMagnetic resonance imaging |
spellingShingle | Hyun Kook Lim Won Sang Jung Jong-Hyun Jeong Ho-Jun Seo Tae-Won Kim Jin-Hee Han Chang Uk Lee Seung Chul Hong Aberrant Gray Matter Structure Associated with Sleep Disturbance in the Drug Naïve Subjects with Alzheimer’s Disease Sleep Medicine Research Sleep disturbances Alzheimer’s disease Voxel based morphometry Magnetic resonance imaging |
title | Aberrant Gray Matter Structure Associated with Sleep Disturbance in the Drug Naïve Subjects with Alzheimer’s Disease |
title_full | Aberrant Gray Matter Structure Associated with Sleep Disturbance in the Drug Naïve Subjects with Alzheimer’s Disease |
title_fullStr | Aberrant Gray Matter Structure Associated with Sleep Disturbance in the Drug Naïve Subjects with Alzheimer’s Disease |
title_full_unstemmed | Aberrant Gray Matter Structure Associated with Sleep Disturbance in the Drug Naïve Subjects with Alzheimer’s Disease |
title_short | Aberrant Gray Matter Structure Associated with Sleep Disturbance in the Drug Naïve Subjects with Alzheimer’s Disease |
title_sort | aberrant gray matter structure associated with sleep disturbance in the drug naive subjects with alzheimer s disease |
topic | Sleep disturbances Alzheimer’s disease Voxel based morphometry Magnetic resonance imaging |
url | http://www.sleepmedres.org/upload/pdf/smr-5-2-43.pdf |
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