Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis

Microvesicles-hydrogel breaks the cycle of cellular senescence by improving mitochondrial function to treat osteoarthritis

Abstract Background Osteoarthritis (OA) is an age-related disease characterised by the accumulation of senescent chondrocytes, which drives its pathogenesis and progression. Senescent cells exhibit distinct features, including mitochondrial dysfunction and the excessive accumulation and release of r...

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Bibliographic Details
Main Authors: Senrui Liu, Shengwen Cheng, Bowen Chen, Pengcheng Xiao, Jingdi Zhan, Jiacheng Liu, Zhuolin Chen, Junyan Liu, Tao Zhang, Yiting Lei, Wei Huang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Nanobiotechnology
Subjects:
Cellular senescence
Mitochondrial dysfunction
Stem cells
Responsive hydrogel
Microvesicles
Online Access:https://doi.org/10.1186/s12951-023-02211-8

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