Risk Factors and Sampling Range Evaluation of Lymph node Metastasis for Non-small Cell Lung Cancer with Diameter ≤2 cm
Background and objective More early-stage non-small cell lung cancer (NSCLC) are diagnosed in time and treated surgically, but systematic lymph node dissection can not bring enough survival benefits for them, and even increase the probability of postoperative complications. This study aims to analyz...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2023-07-01
|
| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2023.102.26 |
| _version_ | 1797687456983678976 |
|---|---|
| author | Tianyu JIN Zhicheng HE Zhihua LI Jianwei TANG Jing XU Weibing WU Liang CHEN |
| author_facet | Tianyu JIN Zhicheng HE Zhihua LI Jianwei TANG Jing XU Weibing WU Liang CHEN |
| author_sort | Tianyu JIN |
| collection | DOAJ |
| description | Background and objective More early-stage non-small cell lung cancer (NSCLC) are diagnosed in time and treated surgically, but systematic lymph node dissection can not bring enough survival benefits for them, and even increase the probability of postoperative complications. This study aims to analyze the risk factors and evaluate mediastinal lymph node metastasis sites in different lung lobes for NSCLC with diameter ≤2 cm, so as to provide reference for surgery. Methods We collected 1051 patients with pulmonary nodule diameter ≤2 cm who were treated by pulmonary lobectomy with lymph node sampling/dissection in Department of Thoracic Surgery of the First Affiliated Hospital with Nanjing Medical University from December 2009 to December 2019. SPSS 26.0 statistical software was used for statistical analysis, to explore the risk factors and evaluate mediastinal lymph node metastasis sites in different lung lobes. Results 95 of 1051 (9.04%) patients presented lymph node metastasis. Male, pathological non-adenocarcinoma, 1 cm<tumor diameter≤2 cm, spread through air spaces (STAS), visceral pleural invasion (VPI), vascular invasion, low differentiation of adenocarcinoma, and micropapillary or solid adenocarcinoma subtype were the risk factors for lymph node metastasis (P<0.01). Male, 1 cm<tumor diameter≤2 cm, STAS, VPI and vascular invasion were independent risk factors for lymph node metastasis (P<0.05). Lymph node metastasis of #2R, #4R, #9 appeared in upper and middle lobe of right lung (P<0.05), and #7 appeared in right lower lobe (P<0.05). Lymph node metastasis of #5 and #6 in the left upper lobe was more common (P<0.05), while metastasis of #7 and #9 had no significant difference (P>0.05). Lymph nodes in group N1 were significantly correlated with lymph node metastasis in groups #2R, #4R, #5, #6, #7 and #9 (P<0.01). Conclusion Lobe-specific lymph node dissection (LSND) can be performed for early-stage NSCLC. Male, pathological non-adenocarcinoma, 1 cm<tumor diameter≤2 cm, STAS, VPI, vascular invasion, low differentiation of adenocarcinoma, and micropapillary or solid adenocarcinoma subtype would increase the risk of lymph node metastasis. |
| first_indexed | 2024-03-12T01:19:18Z |
| format | Article |
| id | doaj.art-24394a08024d4643b771c949a93367b7 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-03-12T01:19:18Z |
| publishDate | 2023-07-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-24394a08024d4643b771c949a93367b72023-09-13T08:32:42ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872023-07-0126750751410.3779/j.issn.1009-3419.2023.102.26Risk Factors and Sampling Range Evaluation of Lymph node Metastasis for
Non-small Cell Lung Cancer with Diameter ≤2 cmTianyu JIN0Zhicheng HE1Zhihua LI2Jianwei TANG3Jing XU4Weibing WU5Liang CHEN6Department of Thoracic Surgery, the First Affiliated Hospital with Nanjing Medical University/Jiangsu Province Hospital,
Nanjing 210000, ChinaDepartment of Thoracic Surgery, the First Affiliated Hospital with Nanjing Medical University/Jiangsu Province Hospital,
Nanjing 210000, ChinaDepartment of Thoracic Surgery, the First Affiliated Hospital with Nanjing Medical University/Jiangsu Province Hospital,
Nanjing 210000, ChinaDepartment of Thoracic Surgery, the First Affiliated Hospital with Nanjing Medical University/Jiangsu Province Hospital,
Nanjing 210000, ChinaDepartment of Thoracic Surgery, the First Affiliated Hospital with Nanjing Medical University/Jiangsu Province Hospital,
Nanjing 210000, ChinaDepartment of Thoracic Surgery, the First Affiliated Hospital with Nanjing Medical University/Jiangsu Province Hospital,
Nanjing 210000, ChinaDepartment of Thoracic Surgery, the First Affiliated Hospital with Nanjing Medical University/Jiangsu Province Hospital,
Nanjing 210000, ChinaBackground and objective More early-stage non-small cell lung cancer (NSCLC) are diagnosed in time and treated surgically, but systematic lymph node dissection can not bring enough survival benefits for them, and even increase the probability of postoperative complications. This study aims to analyze the risk factors and evaluate mediastinal lymph node metastasis sites in different lung lobes for NSCLC with diameter ≤2 cm, so as to provide reference for surgery. Methods We collected 1051 patients with pulmonary nodule diameter ≤2 cm who were treated by pulmonary lobectomy with lymph node sampling/dissection in Department of Thoracic Surgery of the First Affiliated Hospital with Nanjing Medical University from December 2009 to December 2019. SPSS 26.0 statistical software was used for statistical analysis, to explore the risk factors and evaluate mediastinal lymph node metastasis sites in different lung lobes. Results 95 of 1051 (9.04%) patients presented lymph node metastasis. Male, pathological non-adenocarcinoma, 1 cm<tumor diameter≤2 cm, spread through air spaces (STAS), visceral pleural invasion (VPI), vascular invasion, low differentiation of adenocarcinoma, and micropapillary or solid adenocarcinoma subtype were the risk factors for lymph node metastasis (P<0.01). Male, 1 cm<tumor diameter≤2 cm, STAS, VPI and vascular invasion were independent risk factors for lymph node metastasis (P<0.05). Lymph node metastasis of #2R, #4R, #9 appeared in upper and middle lobe of right lung (P<0.05), and #7 appeared in right lower lobe (P<0.05). Lymph node metastasis of #5 and #6 in the left upper lobe was more common (P<0.05), while metastasis of #7 and #9 had no significant difference (P>0.05). Lymph nodes in group N1 were significantly correlated with lymph node metastasis in groups #2R, #4R, #5, #6, #7 and #9 (P<0.01). Conclusion Lobe-specific lymph node dissection (LSND) can be performed for early-stage NSCLC. Male, pathological non-adenocarcinoma, 1 cm<tumor diameter≤2 cm, STAS, VPI, vascular invasion, low differentiation of adenocarcinoma, and micropapillary or solid adenocarcinoma subtype would increase the risk of lymph node metastasis.http://dx.doi.org/10.3779/j.issn.1009-3419.2023.102.26lung neoplasmslymph node metastasisrisk factorslobe-specific lymph node sampling |
| spellingShingle | Tianyu JIN Zhicheng HE Zhihua LI Jianwei TANG Jing XU Weibing WU Liang CHEN Risk Factors and Sampling Range Evaluation of Lymph node Metastasis for Non-small Cell Lung Cancer with Diameter ≤2 cm Chinese Journal of Lung Cancer lung neoplasms lymph node metastasis risk factors lobe-specific lymph node sampling |
| title | Risk Factors and Sampling Range Evaluation of Lymph node Metastasis for
Non-small Cell Lung Cancer with Diameter ≤2 cm |
| title_full | Risk Factors and Sampling Range Evaluation of Lymph node Metastasis for
Non-small Cell Lung Cancer with Diameter ≤2 cm |
| title_fullStr | Risk Factors and Sampling Range Evaluation of Lymph node Metastasis for
Non-small Cell Lung Cancer with Diameter ≤2 cm |
| title_full_unstemmed | Risk Factors and Sampling Range Evaluation of Lymph node Metastasis for
Non-small Cell Lung Cancer with Diameter ≤2 cm |
| title_short | Risk Factors and Sampling Range Evaluation of Lymph node Metastasis for
Non-small Cell Lung Cancer with Diameter ≤2 cm |
| title_sort | risk factors and sampling range evaluation of lymph node metastasis for
non small cell lung cancer with diameter ≤2 cm |
| topic | lung neoplasms lymph node metastasis risk factors lobe-specific lymph node sampling |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2023.102.26 |
| work_keys_str_mv | AT tianyujin riskfactorsandsamplingrangeevaluationoflymphnodemetastasisfornonsmallcelllungcancerwithdiameter2cm AT zhichenghe riskfactorsandsamplingrangeevaluationoflymphnodemetastasisfornonsmallcelllungcancerwithdiameter2cm AT zhihuali riskfactorsandsamplingrangeevaluationoflymphnodemetastasisfornonsmallcelllungcancerwithdiameter2cm AT jianweitang riskfactorsandsamplingrangeevaluationoflymphnodemetastasisfornonsmallcelllungcancerwithdiameter2cm AT jingxu riskfactorsandsamplingrangeevaluationoflymphnodemetastasisfornonsmallcelllungcancerwithdiameter2cm AT weibingwu riskfactorsandsamplingrangeevaluationoflymphnodemetastasisfornonsmallcelllungcancerwithdiameter2cm AT liangchen riskfactorsandsamplingrangeevaluationoflymphnodemetastasisfornonsmallcelllungcancerwithdiameter2cm |