Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms

Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms

Chordoma is a rare cancer that grows in the base of the skull and along the mobile spine from remnants of embryonic notochord tissue. The cornerstone of current treatments is surgical excision with adjuvant radiation therapy, although complete surgical removal is not always possible. Chordomas have...

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Bibliographic Details
Main Authors: Christopher J. Walker, Hua Chang, Leah Henegar, Trinayan Kashyap, Sharon Shacham, Josh Sommer, Michael J. Wick, Joan Levy, Yosef Landesman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
chordoma
CDK inhibition
proteasome inhibition
SINE inhibition
selinexor
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.808021/full

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