Gel-Based Nanocarrier for Intravesical Chemotherapy Delivery: In Vitro and In Vivo Study
Intravesical administration of chemotherapeutic agents can enhance drug accumulation in tumors and reduce systemic side effects. Nanocarriers were developed for intravesical administration and exploit the permeation enhancement effect. In vitro permeation evaluation, the drug transdermal amount and...
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MDPI AG
2020-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/13/11/329 |
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| author | Ting-Yu Chen Ming-Jun Tsai I-Ling Lin Li-Ching Chang Pao-Chu Wu |
| author_facet | Ting-Yu Chen Ming-Jun Tsai I-Ling Lin Li-Ching Chang Pao-Chu Wu |
| author_sort | Ting-Yu Chen |
| collection | DOAJ |
| description | Intravesical administration of chemotherapeutic agents can enhance drug accumulation in tumors and reduce systemic side effects. Nanocarriers were developed for intravesical administration and exploit the permeation enhancement effect. In vitro permeation evaluation, the drug transdermal amount and accumulation amounts in the tissue of gemcitabine-loaded nanocarriers through biological membrane significantly increased about 14.8~33.0-fold and 1.5~14.1-fold respectively, when compared to a control group of 1% gemcitabine saline solution. In in vivo intravesical administration, the drug accumulation amount in bladder tissue of nanocarrier of 75.2 ± 5.4 μg was revealed as being comparably higher than that of the control group of 44.8 ± 6.4 μg. In confocal laser scanning microscopy imagery, the penetration depth of fluorescent dyes-rhodamine was increased from 80 μm up to 120 μm when a nanocarrier was used. This result implies that the nanocarrier is a promising drug delivery agent for intravesical administration. |
| first_indexed | 2024-03-10T15:25:20Z |
| format | Article |
| id | doaj.art-243ae54ce8274043a27d56c6537c37ee |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T15:25:20Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
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| series | Pharmaceuticals |
| spelling | doaj.art-243ae54ce8274043a27d56c6537c37ee2023-11-20T18:04:42ZengMDPI AGPharmaceuticals1424-82472020-10-01131132910.3390/ph13110329Gel-Based Nanocarrier for Intravesical Chemotherapy Delivery: In Vitro and In Vivo StudyTing-Yu Chen0Ming-Jun Tsai1I-Ling Lin2Li-Ching Chang3Pao-Chu Wu4School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Neurology, China Medical University Hospital, Taichung 406040, TaiwanDepartment of Medicine Laboratory Science and Biotechnology, College of Health Science, Kaohsiung Medical University, Kaohsiung 80708, TaiwanSchool of Medicine for International Students, I-Shou University, Kaohsiung 82445, TaiwanSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, TaiwanIntravesical administration of chemotherapeutic agents can enhance drug accumulation in tumors and reduce systemic side effects. Nanocarriers were developed for intravesical administration and exploit the permeation enhancement effect. In vitro permeation evaluation, the drug transdermal amount and accumulation amounts in the tissue of gemcitabine-loaded nanocarriers through biological membrane significantly increased about 14.8~33.0-fold and 1.5~14.1-fold respectively, when compared to a control group of 1% gemcitabine saline solution. In in vivo intravesical administration, the drug accumulation amount in bladder tissue of nanocarrier of 75.2 ± 5.4 μg was revealed as being comparably higher than that of the control group of 44.8 ± 6.4 μg. In confocal laser scanning microscopy imagery, the penetration depth of fluorescent dyes-rhodamine was increased from 80 μm up to 120 μm when a nanocarrier was used. This result implies that the nanocarrier is a promising drug delivery agent for intravesical administration.https://www.mdpi.com/1424-8247/13/11/329intravesical administrationnanocarrierchemotherapeutic agentdrug delivery carriers |
| spellingShingle | Ting-Yu Chen Ming-Jun Tsai I-Ling Lin Li-Ching Chang Pao-Chu Wu Gel-Based Nanocarrier for Intravesical Chemotherapy Delivery: In Vitro and In Vivo Study Pharmaceuticals intravesical administration nanocarrier chemotherapeutic agent drug delivery carriers |
| title | Gel-Based Nanocarrier for Intravesical Chemotherapy Delivery: In Vitro and In Vivo Study |
| title_full | Gel-Based Nanocarrier for Intravesical Chemotherapy Delivery: In Vitro and In Vivo Study |
| title_fullStr | Gel-Based Nanocarrier for Intravesical Chemotherapy Delivery: In Vitro and In Vivo Study |
| title_full_unstemmed | Gel-Based Nanocarrier for Intravesical Chemotherapy Delivery: In Vitro and In Vivo Study |
| title_short | Gel-Based Nanocarrier for Intravesical Chemotherapy Delivery: In Vitro and In Vivo Study |
| title_sort | gel based nanocarrier for intravesical chemotherapy delivery in vitro and in vivo study |
| topic | intravesical administration nanocarrier chemotherapeutic agent drug delivery carriers |
| url | https://www.mdpi.com/1424-8247/13/11/329 |
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