Effects of Elamipretide on Autophagy in Renal Cells of Pigs with Metabolic Syndrome

Effects of Elamipretide on Autophagy in Renal Cells of Pigs with Metabolic Syndrome

Autophagy eliminates excessive nutrients and maintains homeostasis. Obesity and metabolic syndrome (MetS) dysregulate autophagy, possibly partly due to mitochondria injury and inflammation. Elamipretide (ELAM) improves mitochondrial function. We hypothesized that MetS blunts kidney autophagy, which...

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Bibliographic Details
Main Authors: Siting Hong, Ramyar Ghandriz, Sarosh Siddiqi, Xiang-Yang Zhu, Ishran M. Saadiq, Kyra L. Jordan, Hui Tang, Khaled A. Ali, Amir Lerman, Alfonso Eirin, Lilach O. Lerman
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
kidney
metabolic syndrome
autophagy
mitochondria
inflammation
Online Access:https://www.mdpi.com/2073-4409/11/18/2891

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