Leveraging omics to understand the molecular basis of acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with acutely decompensated cirrhosis. In this condition, dysbalanced immune function and excessive systemic inflammation are closely associated with organ failure and high short-term mortality. In this review, we d...
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-08-01
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| Series: | Advances in Laboratory Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/almed-2021-0023 |
| _version_ | 1797806215164592128 |
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| author | Clària Joan |
| author_facet | Clària Joan |
| author_sort | Clària Joan |
| collection | DOAJ |
| description | Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with acutely decompensated cirrhosis. In this condition, dysbalanced immune function and excessive systemic inflammation are closely associated with organ failure and high short-term mortality. In this review, we describe how omic technologies have contributed to the characterization of the hyperinflammatory state in patients with acutely decompensated cirrhosis developing ACLF, with special emphasis on the role of metabolomics, lipidomics and transcriptomics in profiling the triggers (pathogen- and damage-associated molecular patterns [PAMPs and DAMPs]) and effector molecules (cytokines, chemokines, growth factors and bioactive lipid mediators) that lead to activation of the innate immune system. This review also describes how omic approaches can be invaluable tools to accelerate the identification of novel biomarkers that could guide the implementation of novel therapies/interventions aimed at protecting these patients from excessive systemic inflammation and organ failure. |
| first_indexed | 2024-03-13T06:03:54Z |
| format | Article |
| id | doaj.art-243b33dc5bea4bff99154417dbd1183d |
| institution | Directory Open Access Journal |
| issn | 2628-491X |
| language | English |
| last_indexed | 2024-03-13T06:03:54Z |
| publishDate | 2021-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Advances in Laboratory Medicine |
| spelling | doaj.art-243b33dc5bea4bff99154417dbd1183d2023-06-12T06:17:16ZengDe GruyterAdvances in Laboratory Medicine2628-491X2021-08-012451652710.1515/almed-2021-0023Leveraging omics to understand the molecular basis of acute-on-chronic liver failureClària Joan0Biochemistry and Molecular Genetics Service, Hospital Clínic – IDIBAPS, Barcelona, SpainAcute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with acutely decompensated cirrhosis. In this condition, dysbalanced immune function and excessive systemic inflammation are closely associated with organ failure and high short-term mortality. In this review, we describe how omic technologies have contributed to the characterization of the hyperinflammatory state in patients with acutely decompensated cirrhosis developing ACLF, with special emphasis on the role of metabolomics, lipidomics and transcriptomics in profiling the triggers (pathogen- and damage-associated molecular patterns [PAMPs and DAMPs]) and effector molecules (cytokines, chemokines, growth factors and bioactive lipid mediators) that lead to activation of the innate immune system. This review also describes how omic approaches can be invaluable tools to accelerate the identification of novel biomarkers that could guide the implementation of novel therapies/interventions aimed at protecting these patients from excessive systemic inflammation and organ failure.https://doi.org/10.1515/almed-2021-0023advanced liver diseasebioactive lipid mediatorsimmunometabolismimmunosuppressionsystemic inflammation |
| spellingShingle | Clària Joan Leveraging omics to understand the molecular basis of acute-on-chronic liver failure Advances in Laboratory Medicine advanced liver disease bioactive lipid mediators immunometabolism immunosuppression systemic inflammation |
| title | Leveraging omics to understand the molecular basis of acute-on-chronic liver failure |
| title_full | Leveraging omics to understand the molecular basis of acute-on-chronic liver failure |
| title_fullStr | Leveraging omics to understand the molecular basis of acute-on-chronic liver failure |
| title_full_unstemmed | Leveraging omics to understand the molecular basis of acute-on-chronic liver failure |
| title_short | Leveraging omics to understand the molecular basis of acute-on-chronic liver failure |
| title_sort | leveraging omics to understand the molecular basis of acute on chronic liver failure |
| topic | advanced liver disease bioactive lipid mediators immunometabolism immunosuppression systemic inflammation |
| url | https://doi.org/10.1515/almed-2021-0023 |
| work_keys_str_mv | AT clariajoan leveragingomicstounderstandthemolecularbasisofacuteonchronicliverfailure |