Non-Alcoholic Fatty Liver Disease in Obese Youth With Insulin Resistance and Type 2 Diabetes
Currently, Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent form of chronic liver disease in children and adolescents worldwide. Simultaneously to the epidemic spreading of childhood obesity, the rate of affected young has dramatically increased in the last decades with an estimated p...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-04-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.639548/full |
| _version_ | 1830488396034736128 |
|---|---|
| author | Serena Scapaticci Ebe D’Adamo Angelika Mohn Francesco Chiarelli Cosimo Giannini |
| author_facet | Serena Scapaticci Ebe D’Adamo Angelika Mohn Francesco Chiarelli Cosimo Giannini |
| author_sort | Serena Scapaticci |
| collection | DOAJ |
| description | Currently, Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent form of chronic liver disease in children and adolescents worldwide. Simultaneously to the epidemic spreading of childhood obesity, the rate of affected young has dramatically increased in the last decades with an estimated prevalence of NAFLD of 3%–10% in pediatric subjects in the world. The continuous improvement in NAFLD knowledge has significantly defined several risk factors associated to the natural history of this complex liver alteration. Among them, Insulin Resistance (IR) is certainly one of the main features. As well, not surprisingly, abnormal glucose tolerance (prediabetes and diabetes) is highly prevalent among children/adolescents with biopsy-proven NAFLD. In addition, other factors such as genetic, ethnicity, gender, age, puberty and lifestyle might affect the development and progression of hepatic alterations. However, available data are still lacking to confirm whether IR is a risk factor or a consequence of hepatic steatosis. There is also evidence that NAFLD is the hepatic manifestation of Metabolic Syndrome (MetS). In fact, NAFLD often coexist with central obesity, impaired glucose tolerance, dyslipidemia, and hypertension, which represent the main features of MetS. In this Review, main aspects of the natural history and risk factors of the disease are summarized in children and adolescents. In addition, the most relevant scientific evidence about the association between NAFLD and metabolic dysregulation, focusing on clinical, pathogenetic, and histological implication will be provided with some focuses on the main treatment options. |
| first_indexed | 2024-12-21T19:18:18Z |
| format | Article |
| id | doaj.art-243b87be2b9c44658402553f9107d0b6 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-21T19:18:18Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-243b87be2b9c44658402553f9107d0b62022-12-21T18:53:00ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-04-011210.3389/fendo.2021.639548639548Non-Alcoholic Fatty Liver Disease in Obese Youth With Insulin Resistance and Type 2 DiabetesSerena ScapaticciEbe D’AdamoAngelika MohnFrancesco ChiarelliCosimo GianniniCurrently, Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent form of chronic liver disease in children and adolescents worldwide. Simultaneously to the epidemic spreading of childhood obesity, the rate of affected young has dramatically increased in the last decades with an estimated prevalence of NAFLD of 3%–10% in pediatric subjects in the world. The continuous improvement in NAFLD knowledge has significantly defined several risk factors associated to the natural history of this complex liver alteration. Among them, Insulin Resistance (IR) is certainly one of the main features. As well, not surprisingly, abnormal glucose tolerance (prediabetes and diabetes) is highly prevalent among children/adolescents with biopsy-proven NAFLD. In addition, other factors such as genetic, ethnicity, gender, age, puberty and lifestyle might affect the development and progression of hepatic alterations. However, available data are still lacking to confirm whether IR is a risk factor or a consequence of hepatic steatosis. There is also evidence that NAFLD is the hepatic manifestation of Metabolic Syndrome (MetS). In fact, NAFLD often coexist with central obesity, impaired glucose tolerance, dyslipidemia, and hypertension, which represent the main features of MetS. In this Review, main aspects of the natural history and risk factors of the disease are summarized in children and adolescents. In addition, the most relevant scientific evidence about the association between NAFLD and metabolic dysregulation, focusing on clinical, pathogenetic, and histological implication will be provided with some focuses on the main treatment options.https://www.frontiersin.org/articles/10.3389/fendo.2021.639548/fullnon-alcoholic fatty liver diseaseliver steatosissteatohepatitisobesity in childrenmetabolic syndromeinsulin resistance |
| spellingShingle | Serena Scapaticci Ebe D’Adamo Angelika Mohn Francesco Chiarelli Cosimo Giannini Non-Alcoholic Fatty Liver Disease in Obese Youth With Insulin Resistance and Type 2 Diabetes Frontiers in Endocrinology non-alcoholic fatty liver disease liver steatosis steatohepatitis obesity in children metabolic syndrome insulin resistance |
| title | Non-Alcoholic Fatty Liver Disease in Obese Youth With Insulin Resistance and Type 2 Diabetes |
| title_full | Non-Alcoholic Fatty Liver Disease in Obese Youth With Insulin Resistance and Type 2 Diabetes |
| title_fullStr | Non-Alcoholic Fatty Liver Disease in Obese Youth With Insulin Resistance and Type 2 Diabetes |
| title_full_unstemmed | Non-Alcoholic Fatty Liver Disease in Obese Youth With Insulin Resistance and Type 2 Diabetes |
| title_short | Non-Alcoholic Fatty Liver Disease in Obese Youth With Insulin Resistance and Type 2 Diabetes |
| title_sort | non alcoholic fatty liver disease in obese youth with insulin resistance and type 2 diabetes |
| topic | non-alcoholic fatty liver disease liver steatosis steatohepatitis obesity in children metabolic syndrome insulin resistance |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.639548/full |
| work_keys_str_mv | AT serenascapaticci nonalcoholicfattyliverdiseaseinobeseyouthwithinsulinresistanceandtype2diabetes AT ebedadamo nonalcoholicfattyliverdiseaseinobeseyouthwithinsulinresistanceandtype2diabetes AT angelikamohn nonalcoholicfattyliverdiseaseinobeseyouthwithinsulinresistanceandtype2diabetes AT francescochiarelli nonalcoholicfattyliverdiseaseinobeseyouthwithinsulinresistanceandtype2diabetes AT cosimogiannini nonalcoholicfattyliverdiseaseinobeseyouthwithinsulinresistanceandtype2diabetes |