Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation and related mechanisms has led researchers to focus on the microenvironment where pancreatic cancers develop....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2019-01-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12943-018-0927-5 |
| _version_ | 1819148882281496576 |
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| author | Divya Thomas Prakash Radhakrishnan |
| author_facet | Divya Thomas Prakash Radhakrishnan |
| author_sort | Divya Thomas |
| collection | DOAJ |
| description | Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation and related mechanisms has led researchers to focus on the microenvironment where pancreatic cancers develop. The anomalous proliferation of stromal cells, such as pancreatic stellate cells, and an increased deposition of altered matrix proteins create an environment that facilitates tumor growth, metastasis and drug resistance. Here, we summarize our understanding of recent advances in research about the role of fibrosis in pancreatic cancer progression, with particular emphasize on the involvement of fibrotic machineries such as wound healing, extra cellular matrix degradation, and epithelial-to-mesenchymal transition. The precise influence of these mechanisms on the biological behaviors and growth of cancer cells has great impact on clinical therapy and therefore deserves more attention. We also discuss the role of various stromal components in conferring drug resistance to PDAC which further worsening the pessimistic disease prognosis. A more in depth understanding of cancer-stroma crosstalk within the tumor microenvironment and stroma based clinical and translational therapies may provide new therapeutic strategies for the prevention of pancreatic cancer progression. |
| first_indexed | 2024-12-22T13:52:46Z |
| format | Article |
| id | doaj.art-243c12906a414132aac03c34e4c70114 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-22T13:52:46Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-243c12906a414132aac03c34e4c701142022-12-21T18:23:37ZengBMCMolecular Cancer1476-45982019-01-0118111510.1186/s12943-018-0927-5Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosisDivya Thomas0Prakash Radhakrishnan1Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical CenterEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical CenterAbstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation and related mechanisms has led researchers to focus on the microenvironment where pancreatic cancers develop. The anomalous proliferation of stromal cells, such as pancreatic stellate cells, and an increased deposition of altered matrix proteins create an environment that facilitates tumor growth, metastasis and drug resistance. Here, we summarize our understanding of recent advances in research about the role of fibrosis in pancreatic cancer progression, with particular emphasize on the involvement of fibrotic machineries such as wound healing, extra cellular matrix degradation, and epithelial-to-mesenchymal transition. The precise influence of these mechanisms on the biological behaviors and growth of cancer cells has great impact on clinical therapy and therefore deserves more attention. We also discuss the role of various stromal components in conferring drug resistance to PDAC which further worsening the pessimistic disease prognosis. A more in depth understanding of cancer-stroma crosstalk within the tumor microenvironment and stroma based clinical and translational therapies may provide new therapeutic strategies for the prevention of pancreatic cancer progression.http://link.springer.com/article/10.1186/s12943-018-0927-5Pancreatic CancerDesmoplasiaFibrosisStellate cellsExtracellular matrixTumor microenvironment |
| spellingShingle | Divya Thomas Prakash Radhakrishnan Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis Molecular Cancer Pancreatic Cancer Desmoplasia Fibrosis Stellate cells Extracellular matrix Tumor microenvironment |
| title | Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis |
| title_full | Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis |
| title_fullStr | Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis |
| title_full_unstemmed | Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis |
| title_short | Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis |
| title_sort | tumor stromal crosstalk in pancreatic cancer and tissue fibrosis |
| topic | Pancreatic Cancer Desmoplasia Fibrosis Stellate cells Extracellular matrix Tumor microenvironment |
| url | http://link.springer.com/article/10.1186/s12943-018-0927-5 |
| work_keys_str_mv | AT divyathomas tumorstromalcrosstalkinpancreaticcancerandtissuefibrosis AT prakashradhakrishnan tumorstromalcrosstalkinpancreaticcancerandtissuefibrosis |