CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy
The expanding clinical application of CDK4- and CDK6-inhibiting drugs in the managements of breast cancer has raised a great interest in testing these drugs in other neoplasms. The potential of combining these drugs with other therapeutic approaches seems to be an interesting work-ground to explore....
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/16/8391 |
| _version_ | 1797523617985069056 |
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| author | Valerio Nardone Marcella Barbarino Antonio Angrisani Pierpaolo Correale Pierpaolo Pastina Salvatore Cappabianca Alfonso Reginelli Luciano Mutti Clelia Miracco Rocco Giannicola Antonio Giordano Luigi Pirtoli |
| author_facet | Valerio Nardone Marcella Barbarino Antonio Angrisani Pierpaolo Correale Pierpaolo Pastina Salvatore Cappabianca Alfonso Reginelli Luciano Mutti Clelia Miracco Rocco Giannicola Antonio Giordano Luigi Pirtoli |
| author_sort | Valerio Nardone |
| collection | DOAJ |
| description | The expanding clinical application of CDK4- and CDK6-inhibiting drugs in the managements of breast cancer has raised a great interest in testing these drugs in other neoplasms. The potential of combining these drugs with other therapeutic approaches seems to be an interesting work-ground to explore. Even though a potential integration of CDK4 and CDK6 inhibitors with radiotherapy (RT) has been hypothesized, this kind of approach has not been sufficiently pursued, neither in preclinical nor in clinical studies. Similarly, the most recent discoveries focusing on autophagy, as a possible target pathway able to enhance the antitumor efficacy of CDK4 and CDK6 inhibitors is promising but needs more investigations. The aim of this review is to discuss the recent literature on the field in order to infer a rational combination strategy including cyclin-D1/CDK4-CDK6 inhibitors, RT, and/or other anticancer agents targeting G1-S phase cell cycle transition. |
| first_indexed | 2024-03-10T08:45:33Z |
| format | Article |
| id | doaj.art-243d17d65b1c4011b4886e1439439fa1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:45:33Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-243d17d65b1c4011b4886e1439439fa12023-11-22T07:54:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216839110.3390/ijms22168391CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for AutophagyValerio Nardone0Marcella Barbarino1Antonio Angrisani2Pierpaolo Correale3Pierpaolo Pastina4Salvatore Cappabianca5Alfonso Reginelli6Luciano Mutti7Clelia Miracco8Rocco Giannicola9Antonio Giordano10Luigi Pirtoli11Department of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Medical Biotechnologies, University of Siena, 53100 Siena, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyMedical Oncology Unit, Grand Metropolitan Hospital “Bianchi-Melacrino-Morelli”, 89124 Reggio Calabria, ItalySection of Radiation Oncology, Medical School, University of Siena, 53100 Siena, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalySbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19104, USAPathological Anatomy Unit, Department of Medical, Surgical and Neurological Science, University of Siena, 53100 Siena, ItalyMedical Oncology Unit, Grand Metropolitan Hospital “Bianchi-Melacrino-Morelli”, 89124 Reggio Calabria, ItalyDepartment of Medical Biotechnologies, University of Siena, 53100 Siena, ItalySbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19104, USAThe expanding clinical application of CDK4- and CDK6-inhibiting drugs in the managements of breast cancer has raised a great interest in testing these drugs in other neoplasms. The potential of combining these drugs with other therapeutic approaches seems to be an interesting work-ground to explore. Even though a potential integration of CDK4 and CDK6 inhibitors with radiotherapy (RT) has been hypothesized, this kind of approach has not been sufficiently pursued, neither in preclinical nor in clinical studies. Similarly, the most recent discoveries focusing on autophagy, as a possible target pathway able to enhance the antitumor efficacy of CDK4 and CDK6 inhibitors is promising but needs more investigations. The aim of this review is to discuss the recent literature on the field in order to infer a rational combination strategy including cyclin-D1/CDK4-CDK6 inhibitors, RT, and/or other anticancer agents targeting G1-S phase cell cycle transition.https://www.mdpi.com/1422-0067/22/16/8391cyclin inhibitorsradiotherapyautophagy |
| spellingShingle | Valerio Nardone Marcella Barbarino Antonio Angrisani Pierpaolo Correale Pierpaolo Pastina Salvatore Cappabianca Alfonso Reginelli Luciano Mutti Clelia Miracco Rocco Giannicola Antonio Giordano Luigi Pirtoli CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy International Journal of Molecular Sciences cyclin inhibitors radiotherapy autophagy |
| title | CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy |
| title_full | CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy |
| title_fullStr | CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy |
| title_full_unstemmed | CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy |
| title_short | CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy |
| title_sort | cdk4 cdk6 cyclin d1 complex inhibition and radiotherapy for cancer control a role for autophagy |
| topic | cyclin inhibitors radiotherapy autophagy |
| url | https://www.mdpi.com/1422-0067/22/16/8391 |
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