Progress in the Enantioseparation of β-Blockers by Chromatographic Methods
β-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g., timolol, are clinically marketed as an optic...
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MDPI AG
2021-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/2/468 |
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| author | Yiwen Yang Yehui Wang Zongbi Bao Qiwei Yang Zhiguo Zhang Qilong Ren |
| author_facet | Yiwen Yang Yehui Wang Zongbi Bao Qiwei Yang Zhiguo Zhang Qilong Ren |
| author_sort | Yiwen Yang |
| collection | DOAJ |
| description | β-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g., timolol, are clinically marketed as an optically pure enantiomer. Therefore, the separation of racemates of β-blockers is essential both in the laboratory and industry. Many approaches have been explored to obtain the single enantiomeric β-blocker, including high performance liquid chromatography, supercritical fluid chromatography and simulated moving bed chromatography. In this article, a review is presented on different chromatographic methods applied for the enantioseparation of β-blockers, covering high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC) and simulated moving bed chromatography (SMB). |
| first_indexed | 2024-03-09T04:30:31Z |
| format | Article |
| id | doaj.art-243d3253645a4525a3e79fcab0228883 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:30:31Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-243d3253645a4525a3e79fcab02288832023-12-03T13:35:31ZengMDPI AGMolecules1420-30492021-01-0126246810.3390/molecules26020468Progress in the Enantioseparation of β-Blockers by Chromatographic MethodsYiwen Yang0Yehui Wang1Zongbi Bao2Qiwei Yang3Zhiguo Zhang4Qilong Ren5Institute of Pharmaceutical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaInstitute of Pharmaceutical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaInstitute of Pharmaceutical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaInstitute of Pharmaceutical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaInstitute of Pharmaceutical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, ChinaInstitute of Pharmaceutical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, Chinaβ-adrenergic antagonists (β-blockers) with at least one chiral center are an exceedingly important class of drugs used mostly to treat cardiovascular diseases. At least 70 β-blockers have been investigated in history. However, only a few β-blockers, e.g., timolol, are clinically marketed as an optically pure enantiomer. Therefore, the separation of racemates of β-blockers is essential both in the laboratory and industry. Many approaches have been explored to obtain the single enantiomeric β-blocker, including high performance liquid chromatography, supercritical fluid chromatography and simulated moving bed chromatography. In this article, a review is presented on different chromatographic methods applied for the enantioseparation of β-blockers, covering high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC) and simulated moving bed chromatography (SMB).https://www.mdpi.com/1420-3049/26/2/468β-blockerschromatographyenantioseparationSFCSMBHPLC |
| spellingShingle | Yiwen Yang Yehui Wang Zongbi Bao Qiwei Yang Zhiguo Zhang Qilong Ren Progress in the Enantioseparation of β-Blockers by Chromatographic Methods Molecules β-blockers chromatography enantioseparation SFC SMB HPLC |
| title | Progress in the Enantioseparation of β-Blockers by Chromatographic Methods |
| title_full | Progress in the Enantioseparation of β-Blockers by Chromatographic Methods |
| title_fullStr | Progress in the Enantioseparation of β-Blockers by Chromatographic Methods |
| title_full_unstemmed | Progress in the Enantioseparation of β-Blockers by Chromatographic Methods |
| title_short | Progress in the Enantioseparation of β-Blockers by Chromatographic Methods |
| title_sort | progress in the enantioseparation of β blockers by chromatographic methods |
| topic | β-blockers chromatography enantioseparation SFC SMB HPLC |
| url | https://www.mdpi.com/1420-3049/26/2/468 |
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