Monte Carlo simulation of physical dose enhancement in core-shell magnetic gold nanoparticles with TOPAS
The application of metal nanoparticles (MNPs) as sensitization materials is a common strategy that is used to study dose enhancement in radiotherapy. Recent in vitro tests have revealed that magnetic gold nanoparticles (NPs) can be used in cancer therapy under a magnetic field to enhance the synergi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.992358/full |
| _version_ | 1797995093408350208 |
|---|---|
| author | Xiaohan Xu Xiaohan Xu Jianan Wu Jianan Wu Zhitao Dai Rui Hu Yaoqin Xie Luhua Wang Luhua Wang |
| author_facet | Xiaohan Xu Xiaohan Xu Jianan Wu Jianan Wu Zhitao Dai Rui Hu Yaoqin Xie Luhua Wang Luhua Wang |
| author_sort | Xiaohan Xu |
| collection | DOAJ |
| description | The application of metal nanoparticles (MNPs) as sensitization materials is a common strategy that is used to study dose enhancement in radiotherapy. Recent in vitro tests have revealed that magnetic gold nanoparticles (NPs) can be used in cancer therapy under a magnetic field to enhance the synergistic efficiency in radiotherapy and photothermal therapy. However, magnetic gold NPs have rarely been studied as sensitization materials. In this study, we obtained further results of the sensitization properties of the magnetic gold NPs (Fe3O4@AuNPs) with or without magnetic field using the TOPAS-nBio Monte Carlo (MC) toolkit. We analyzed the properties of Fe3O4@AuNP in a single NP model and in a cell model under monoenergetic photons and brachytherapy, and we investigated whether the magnetic field contributes to the physical sensitization process. Our results revealed that the dose enhancement factor (DEF) of Fe3O4@AuNPs was lower than that of gold nanoparticles (AuNPs) in a single NP and in a cell irradiated by monoenergetic photons. But it’s worth mentioning that under a magnetic field, the DEF of targeted Fe3O4@AuNPs in a cell model with a clinical brachytherapy source was 22.17% (cytoplasm) and 6.89% (nucleus) higher than those of AuNPs (50 mg/mL). The Fe3O4@AuNPs were proved as an effective sensitization materials when combined with the magnetic field in MC simulation for the first time, which contributes to the research on in vitro tests on radiosensitization as well as clinical research in future. |
| first_indexed | 2024-04-11T09:56:02Z |
| format | Article |
| id | doaj.art-243d5338b41b4f4cb62da449654cebc9 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T09:56:02Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-243d5338b41b4f4cb62da449654cebc92022-12-22T04:30:37ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.992358992358Monte Carlo simulation of physical dose enhancement in core-shell magnetic gold nanoparticles with TOPASXiaohan Xu0Xiaohan Xu1Jianan Wu2Jianan Wu3Zhitao Dai4Rui Hu5Yaoqin Xie6Luhua Wang7Luhua Wang8Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, ChinaDepartment of Radiation Oncology, Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal Hospital, Suzhou, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, ChinaDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaThe application of metal nanoparticles (MNPs) as sensitization materials is a common strategy that is used to study dose enhancement in radiotherapy. Recent in vitro tests have revealed that magnetic gold nanoparticles (NPs) can be used in cancer therapy under a magnetic field to enhance the synergistic efficiency in radiotherapy and photothermal therapy. However, magnetic gold NPs have rarely been studied as sensitization materials. In this study, we obtained further results of the sensitization properties of the magnetic gold NPs (Fe3O4@AuNPs) with or without magnetic field using the TOPAS-nBio Monte Carlo (MC) toolkit. We analyzed the properties of Fe3O4@AuNP in a single NP model and in a cell model under monoenergetic photons and brachytherapy, and we investigated whether the magnetic field contributes to the physical sensitization process. Our results revealed that the dose enhancement factor (DEF) of Fe3O4@AuNPs was lower than that of gold nanoparticles (AuNPs) in a single NP and in a cell irradiated by monoenergetic photons. But it’s worth mentioning that under a magnetic field, the DEF of targeted Fe3O4@AuNPs in a cell model with a clinical brachytherapy source was 22.17% (cytoplasm) and 6.89% (nucleus) higher than those of AuNPs (50 mg/mL). The Fe3O4@AuNPs were proved as an effective sensitization materials when combined with the magnetic field in MC simulation for the first time, which contributes to the research on in vitro tests on radiosensitization as well as clinical research in future.https://www.frontiersin.org/articles/10.3389/fonc.2022.992358/fullradiotherapymagnetic gold nanoparticledose enhancement factormagnetic fieldTOPAS |
| spellingShingle | Xiaohan Xu Xiaohan Xu Jianan Wu Jianan Wu Zhitao Dai Rui Hu Yaoqin Xie Luhua Wang Luhua Wang Monte Carlo simulation of physical dose enhancement in core-shell magnetic gold nanoparticles with TOPAS Frontiers in Oncology radiotherapy magnetic gold nanoparticle dose enhancement factor magnetic field TOPAS |
| title | Monte Carlo simulation of physical dose enhancement in core-shell magnetic gold nanoparticles with TOPAS |
| title_full | Monte Carlo simulation of physical dose enhancement in core-shell magnetic gold nanoparticles with TOPAS |
| title_fullStr | Monte Carlo simulation of physical dose enhancement in core-shell magnetic gold nanoparticles with TOPAS |
| title_full_unstemmed | Monte Carlo simulation of physical dose enhancement in core-shell magnetic gold nanoparticles with TOPAS |
| title_short | Monte Carlo simulation of physical dose enhancement in core-shell magnetic gold nanoparticles with TOPAS |
| title_sort | monte carlo simulation of physical dose enhancement in core shell magnetic gold nanoparticles with topas |
| topic | radiotherapy magnetic gold nanoparticle dose enhancement factor magnetic field TOPAS |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.992358/full |
| work_keys_str_mv | AT xiaohanxu montecarlosimulationofphysicaldoseenhancementincoreshellmagneticgoldnanoparticleswithtopas AT xiaohanxu montecarlosimulationofphysicaldoseenhancementincoreshellmagneticgoldnanoparticleswithtopas AT jiananwu montecarlosimulationofphysicaldoseenhancementincoreshellmagneticgoldnanoparticleswithtopas AT jiananwu montecarlosimulationofphysicaldoseenhancementincoreshellmagneticgoldnanoparticleswithtopas AT zhitaodai montecarlosimulationofphysicaldoseenhancementincoreshellmagneticgoldnanoparticleswithtopas AT ruihu montecarlosimulationofphysicaldoseenhancementincoreshellmagneticgoldnanoparticleswithtopas AT yaoqinxie montecarlosimulationofphysicaldoseenhancementincoreshellmagneticgoldnanoparticleswithtopas AT luhuawang montecarlosimulationofphysicaldoseenhancementincoreshellmagneticgoldnanoparticleswithtopas AT luhuawang montecarlosimulationofphysicaldoseenhancementincoreshellmagneticgoldnanoparticleswithtopas |