Hematological, Biochemical, Histopathological and 1H-NMR Metabolomics Application in Acute Toxicity Evaluation of Clinacanthus nutans Water Leaf Extract

Hematological, Biochemical, Histopathological and 1H-NMR Metabolomics Application in Acute Toxicity Evaluation of Clinacanthus nutans Water Leaf Extract

Show other versions (1)

The present study aims for the first time to provide the in vivo acute toxicological profile of the highest dose of Clinacanthus nutans (Burm. f.) Lindau water leaf extract according to the Organization for economic co-operation and development (OECD) 423 guidelines through conventional toxicity and...

Full description

Bibliographic Details
Main Authors:	Leng Wei Khoo, Audrey Siew Foong Kow, M. Maulidiani, Ming Tatt Lee, Chin Ping Tan, Khozirah Shaari, Chau Ling Tham, Faridah Abas
Format:	Article
Language:	English
Published:	MDPI AG 2018-08-01
Series:	Molecules
Subjects:	Clinacanthus nutans medicinal plant biochemical test histopathology urinary metabolomics toxicity 1H-NMR metabolomics metabolic pathway
Online Access:	http://www.mdpi.com/1420-3049/23/9/2172

Similar Items

Effects of Clinacanthus nutans leaf extract on lipopolysaccharide -induced neuroinflammation in rats: A behavioral and 1H NMR-based metabolomics study
by: Amalina Ahmad Azam, et al.
Published: (2019-02-01)

Multi-Platform Metabolomics Analyses Revealed the Complexity of Serum Metabolites in LPS-Induced Neuroinflammed Rats Treated with Clinacanthus nutans Aqueous Extract
by: Amalina Ahmad Azam, et al.
Published: (2021-06-01)

NMR and LCMS analytical platforms exhibited the nephroprotective effect of Clinacanthus nutans in cisplatin-induced nephrotoxicity in the in vitro condition
by: Ilya Iryani Mahmod, et al.
Published: (2020-10-01)

Clinacanthus nutans (Burm. f.) Lindau Ethanol Extract Inhibits Hepatoma in Mice through Upregulation of the Immune Response
by: Danmin Huang, et al.
Published: (2015-09-01)

Antioxidant activity and protective effect against oxidative hemolysis of Clinacanthus nutans (Burm.f) Lindau.
by: Chantana Aromdee, et al.
Published: (2007-03-01)

Study on the in Vitro Digestion Characteristics of Polysaccharides Emulsion from Clinacanthus nutans
by: Xiaoqian HUANG, et al.
Published: (2023-10-01)

Pengaruh Pemberian Ekstrak Dandang Gendis (Clinacanthus nutans) Terhadap Kadar Glukosa Darah pada Tikus Wistar Model Diabetes Melitus
by: Nena Ristra Dewinta, et al.
Published: (2020-03-01)

Effect of Clinacanthus nutans leaf chloroform extract on reducing nitric oxide in fibroblasts
by: Erdita Hapsari, et al.
Published: (2023-01-01)

Effect of the methanol leaves extract of Clinacanthus nutans on the activity of acetylcholinesterase in male mice
by: Lau KW, et al.
Published: (2014-01-01)

Chemical composition and cytotoxic properties of Clinacanthus nutans root extracts
by: Peik Lin Teoh, et al.
Published: (2017-01-01)

Complete plastome sequence of Clinacanthus nutans (Acanthaceae): a medicinal species in Southern China
by: Mei-Ning Li, et al.
Published: (2019-01-01)

Clinacanthus nutans standardized fraction arrested SiHa cells at G1/S and induced apoptosis via upregulation of p53
by: Nik Aina Syazana Nik Zainuddin, et al.
Published: (2020-01-01)

The synergism of Clinacanthus nutans Lindau extracts with gemcitabine: downregulation of anti-apoptotic markers in squamous pancreatic ductal adenocarcinoma
by: Ling-Wei Hii, et al.
Published: (2019-09-01)

Water extract of Clinacanthus nutans leaves exhibits in vitro, ex vivo and in vivo anti-angiogenic activities in endothelial cell via suppression of cell proliferation
by: Chin Theng Ng, et al.
Published: (2018-07-01)

Anti-Inflammatory Effects of Phytochemical Components of <i>Clinacanthus nutans</i>
by: Wei-Yi Ong, et al.
Published: (2022-06-01)

Subacute Oral Administration of <i>Clinacanthus nutans</i> Ethanolic Leaf Extract Induced Liver and Kidney Toxicities in ICR Mice
by: Abdullahi Aliyu, et al.
Published: (2020-06-01)

Antiviral and Immunomodulatory Activities of <i>Clinacanthus nutans</i> (Burm. f.) Lindau
by: Chung-Ming Lin, et al.
Published: (2023-06-01)

Effect of Clinacanthus nutans leaf extract on oral mucosal burns and tongue wounds: An in-vivo study
by: Moehamad Orliando Roeslan, et al.
Published: (2021-01-01)

Evaluation of the sub–acute oral toxic effect of methanol extract of Clinacanthus nutans leaves in rats
by: Xiu Wen P'ng, et al.
Published: (2013-01-01)

Characterization of α-Glucosidase Inhibitors from Clinacanthus nutans Lindau Leaves by Gas Chromatography-Mass Spectrometry-Based Metabolomics and Molecular Docking Simulation
by: Suganya Murugesu, et al.
Published: (2018-09-01)

Metabolomic Approach for Rapid Identification of Antioxidants in <i>Clinacanthus nutans</i> Leaves with Liver Protective Potential
by: Kai Song Ng, et al.
Published: (2022-06-01)

Enhanced production of lupeol through elicitation in in vitro shoot cultures of snake grass (Clinacanthus nutans)
by: Somarajan L. CHIPPY, et al.
Published: (2022-11-01)

Effects of Clinacanthus nutans Extracts on Cytokine Secretion in PMA-Induced U937 Macrophage Cells
by: Swee Hong Ooi, et al.
Published: (2021-04-01)

Anti-aging Effect and Mechanism of Ethanol Extract of Clinacanthus nutans on Caenorhabditis elegans
by: Yanping ZHUANG, et al.
Published: (2023-06-01)

Hematological, biochemical, histopathological and 1H-NMR metabolomics application in acute toxicity evaluation of clinacanthus nutans water leaf extract
by: Leng, Wei Khoo, et al.
Published: (2018)

Vermicompost Supplementation Improves the Stability of Bioactive Anthocyanin and Phenolic Compounds in Clinacanthus nutans Lindau
by: Zuhaili Yusof, et al.
Published: (2018-06-01)

Antioxidant Effects, Antiproliferative Effects, and Molecular Docking of <i>Clinacanthus nutans</i> Leaf Extracts
by: Noor Zafirah Ismail, et al.
Published: (2020-04-01)

Phytochemical, Metabolite Compound, and Antioxidant Activity of Clinacanthus nutans Leaf Extract from Indonesia
by: Nurlaili Susanti, et al.
Published: (2023-01-01)

Qualitative and Quantitative Phytochemical Analysis and Antioxidant Properties of Leaves and Stems of Clinacanthus nutans (Burm. f.) Lindau from Two Herbal Farms of Negeri Sembilan, Malaysia
by: Hui Sam Kong, et al.
Published: (2019-06-01)

Optimization of biogenic synthesis of silver nanoparticles from flavonoid-rich Clinacanthus nutans leaf and stem aqueous extracts
by: Siti Nur Aishah Mat Yusuf, et al.
Published: (2020-07-01)

Mechanisms underlying the anti-inflammatory effects of Clinacanthus nutans Lindau extracts: inhibition of cytokine production and Toll-like receptor-4 activation
by: Chun Wai eMai, et al.
Published: (2016-02-01)

Plasma and urine metabolite profiling reveals the protective effect of Clinacanthus nutans in an ovalbumin-induced anaphylaxis model: ¹H-NMR metabolomics approach
by: Khoo, Leng Wei, et al.
Published: (2018)

In Vitro Responses of Plant Growth Factors on Growth, Yield, Phenolics Content and Antioxidant Activities of <i>Clinacanthus nutans</i> (Sabah Snake Grass)
by: Zainol Haida, et al.
Published: (2020-08-01)

In vitro antioxidant and, α-glucosidase inhibitory activities and comprehensive metabolite profiling of methanol extract and its fractions from Clinacanthus nutans
by: Md. Ariful Alam, et al.
Published: (2017-03-01)

Fabrication and Characterization of <i>Clinacanthus nutans</i> Mediated Reduced Graphene Oxide Using a Green Approach
by: Dharshini Perumal, et al.
Published: (2022-10-01)

Exploring Clinacanthus nutans leaf different solvent extracts on antiproliferative effects induced metastasis through apoptosis and cell cycle against MCF-7 human breast cancer cell lines
by: Zaleha Md Toha, et al.
Published: (2022-12-01)

Anti-Inflammatory Activity of Glyceryl 1,3-Distearate Identified from <i>Clinacanthus nutans</i> Extract against Bovine Mastitis Pathogens
by: Saruda Thongyim, et al.
Published: (2023-03-01)

Antibiotic-Antiapoptotic Dual Function of <i>Clinacanthus nutans</i> (Burm. f.) Lindau Leaf Extracts against Bovine Mastitis
by: Aussara Panya, et al.
Published: (2020-07-01)

Clinacanthus nutans: Its potential against diabetic vascular diseases
by: Ahmad Khusairi Azemi, et al.
Published: (2021-04-01)

Anti-herpes simplex virus activities of monogalactosyl diglyceride and digalactosyl diglyceride from Clinacanthus nutans, a traditional Thai herbal medicine
by: Sirada Pongmuangmul, et al.
Published: (2016-03-01)