Korean turmeric is effective for dyslipidemia in human intervention study
Background: Turmeric is a plant that belongs to the ginger family, Zingiberaceae, and is one of the main ingredients in curry powder. Turmeric is often called the golden spice and has been used for medicinal purposes for thousands of years. Curcumin, which gives turmeric its yellow color, has been c...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2016-09-01
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| Series: | Journal of Ethnic Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352618116300713 |
| _version_ | 1818623809877442560 |
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| author | Jin Hee Kim Hye Jeong Yang Yong-Jae Kim Sunmin Park Ok-hee Lee Kang Sung Kim Min Jung Kim |
| author_facet | Jin Hee Kim Hye Jeong Yang Yong-Jae Kim Sunmin Park Ok-hee Lee Kang Sung Kim Min Jung Kim |
| author_sort | Jin Hee Kim |
| collection | DOAJ |
| description | Background: Turmeric is a plant that belongs to the ginger family, Zingiberaceae, and is one of the main ingredients in curry powder. Turmeric is often called the golden spice and has been used for medicinal purposes for thousands of years. Curcumin, which gives turmeric its yellow color, has been confirmed to have antioxidant, anti-inflammatory, and anti-infectious effects. It is also known to prevent dementia and promote liver health. For these reasons, turmeric is regarded as a therapeutic food additive with many health benefits beyond its nutritional value. In this paper, the health benefits of turmeric were examined through human intervention studies.
Methods: Thirty chosen individuals (28 men and 2 women) with slightly elevated alanine aminotransaminase levels consumed 1 g of turmeric powder (TP) as two capsules after each meal, three times a day, during the test period of 12 weeks. Changes in the lipid profile and in the levels of serum glucose, malondialdehyde, and metabolites in the sera were measured prior to and after TP consumption.
Results: The participants exhibited dyslipidemia, fasting hyperglycemia, and oxidative stress prior to TP treatment, and these symptoms were alleviated after treatment. On metabolomics analysis of sera, levels of branch-chained amino acids (valine and leucine/isoleucine) were decreased, whereas those of aromatic amino acids (tryptophan and phenylalanine) were increased. Pronounced changes were also noted in the levels of total lysophosphatidylcholine (lysoPC) and acylcarnitine: the levels of total lysoPC were decreased whereas those of acylcarnitine were increased. Serum levels of xanthine and hypoxanthine, which are intermediates of purine degradation, were increased in the participants, although that of the final product, uric acid, was decreased.
Conclusion: Oral consumption of TP alleviated dyslipidemia and changed metabolites patterns by accelerating metabolic activities with less oxidative stress in participants with mild liver dysfunction. |
| first_indexed | 2024-12-16T18:46:58Z |
| format | Article |
| id | doaj.art-244139d297e9476e81c3846d568dffa2 |
| institution | Directory Open Access Journal |
| issn | 2352-6181 |
| language | English |
| last_indexed | 2024-12-16T18:46:58Z |
| publishDate | 2016-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ethnic Foods |
| spelling | doaj.art-244139d297e9476e81c3846d568dffa22022-12-21T22:20:49ZengBMCJournal of Ethnic Foods2352-61812016-09-013321322110.1016/j.jef.2016.08.006Korean turmeric is effective for dyslipidemia in human intervention studyJin Hee Kim0Hye Jeong Yang1Yong-Jae Kim2Sunmin Park3Ok-hee Lee4Kang Sung Kim5Min Jung Kim6Korea Food Research Institute, Sungnam, Republic of KoreaKorea Food Research Institute, Sungnam, Republic of KoreaKorea INS Pharmaceutical Co., Jeollanam-do, Republic of KoreaDepartment of Food Science & Nutrition, Hoseo University, Asan, Republic of KoreaDepartment of Food Science & Nutrition, Yongin University, Yongin, Republic of KoreaDepartment of Food Science & Nutrition, Yongin University, Yongin, Republic of KoreaKorea Food Research Institute, Sungnam, Republic of KoreaBackground: Turmeric is a plant that belongs to the ginger family, Zingiberaceae, and is one of the main ingredients in curry powder. Turmeric is often called the golden spice and has been used for medicinal purposes for thousands of years. Curcumin, which gives turmeric its yellow color, has been confirmed to have antioxidant, anti-inflammatory, and anti-infectious effects. It is also known to prevent dementia and promote liver health. For these reasons, turmeric is regarded as a therapeutic food additive with many health benefits beyond its nutritional value. In this paper, the health benefits of turmeric were examined through human intervention studies. Methods: Thirty chosen individuals (28 men and 2 women) with slightly elevated alanine aminotransaminase levels consumed 1 g of turmeric powder (TP) as two capsules after each meal, three times a day, during the test period of 12 weeks. Changes in the lipid profile and in the levels of serum glucose, malondialdehyde, and metabolites in the sera were measured prior to and after TP consumption. Results: The participants exhibited dyslipidemia, fasting hyperglycemia, and oxidative stress prior to TP treatment, and these symptoms were alleviated after treatment. On metabolomics analysis of sera, levels of branch-chained amino acids (valine and leucine/isoleucine) were decreased, whereas those of aromatic amino acids (tryptophan and phenylalanine) were increased. Pronounced changes were also noted in the levels of total lysophosphatidylcholine (lysoPC) and acylcarnitine: the levels of total lysoPC were decreased whereas those of acylcarnitine were increased. Serum levels of xanthine and hypoxanthine, which are intermediates of purine degradation, were increased in the participants, although that of the final product, uric acid, was decreased. Conclusion: Oral consumption of TP alleviated dyslipidemia and changed metabolites patterns by accelerating metabolic activities with less oxidative stress in participants with mild liver dysfunction.http://www.sciencedirect.com/science/article/pii/S2352618116300713liver functionmass spectrophotometermetabolitesturmeric powder |
| spellingShingle | Jin Hee Kim Hye Jeong Yang Yong-Jae Kim Sunmin Park Ok-hee Lee Kang Sung Kim Min Jung Kim Korean turmeric is effective for dyslipidemia in human intervention study Journal of Ethnic Foods liver function mass spectrophotometer metabolites turmeric powder |
| title | Korean turmeric is effective for dyslipidemia in human intervention study |
| title_full | Korean turmeric is effective for dyslipidemia in human intervention study |
| title_fullStr | Korean turmeric is effective for dyslipidemia in human intervention study |
| title_full_unstemmed | Korean turmeric is effective for dyslipidemia in human intervention study |
| title_short | Korean turmeric is effective for dyslipidemia in human intervention study |
| title_sort | korean turmeric is effective for dyslipidemia in human intervention study |
| topic | liver function mass spectrophotometer metabolites turmeric powder |
| url | http://www.sciencedirect.com/science/article/pii/S2352618116300713 |
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