Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo
Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2022.2127507 |
| _version_ | 1798001320983003136 |
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| author | Ernesto Gargiulo Elodie Viry Etienne Moussay Jerome Paggetti |
| author_facet | Ernesto Gargiulo Elodie Viry Etienne Moussay Jerome Paggetti |
| author_sort | Ernesto Gargiulo |
| collection | DOAJ |
| description | Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters. |
| first_indexed | 2024-04-11T11:34:18Z |
| format | Article |
| id | doaj.art-2442a5f52a1d4cfe86c1d3ff30f7f638 |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2024-04-11T11:34:18Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-2442a5f52a1d4cfe86c1d3ff30f7f6382022-12-22T04:26:01ZengTaylor & Francis GroupOncoImmunology2162-402X2022-12-0111110.1080/2162402X.2022.2127507Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivoErnesto Gargiulo0Elodie Viry1Etienne Moussay2Jerome Paggetti3Tumor Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, LuxembourgTumor Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, LuxembourgTumor Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, LuxembourgTumor Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, LuxembourgRecently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.https://www.tandfonline.com/doi/10.1080/2162402X.2022.2127507Small extracellular vesiclesexosomesCLLtumor microenvironmenttumor immune escapesEV-based biomarkers |
| spellingShingle | Ernesto Gargiulo Elodie Viry Etienne Moussay Jerome Paggetti Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo OncoImmunology Small extracellular vesicles exosomes CLL tumor microenvironment tumor immune escape sEV-based biomarkers |
| title | Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo |
| title_full | Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo |
| title_fullStr | Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo |
| title_full_unstemmed | Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo |
| title_short | Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo |
| title_sort | small extracellular vesicles multi faceted tools for leukemia immune evasion in vivo |
| topic | Small extracellular vesicles exosomes CLL tumor microenvironment tumor immune escape sEV-based biomarkers |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2022.2127507 |
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