Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms.

Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms.

Extracellular adenosine, a danger signal, can cause hypothermia. We generated mice lacking neuronal adenosine A1 receptors (A1AR, encoded by the Adora1 gene) to examine the contribution of these receptors to hypothermia. Intracerebroventricular injection of the selective A1AR agonist (Cl-ENBA, 5...

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Bibliographic Details
Main Authors: Haley S Province, Cuiying Xiao, Allison S Mogul, Ankita Sahoo, Kenneth A Jacobson, Ramón A Piñol, Oksana Gavrilova, Marc L Reitman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0243986

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