Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice
Objective(s): Because of the high total phenolic contents of Feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. Materials and Methods: Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2014-01-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/pdf_2159_e11f36271ecbbe0510efc3d2918fcea9.html |
| _version_ | 1818682385649106944 |
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| author | Mohammad Karami Faezeh Karimian Nokabadi Mohammad Ali Ebrahimzadeh Farshad Naghshvar |
| author_facet | Mohammad Karami Faezeh Karimian Nokabadi Mohammad Ali Ebrahimzadeh Farshad Naghshvar |
| author_sort | Mohammad Karami |
| collection | DOAJ |
| description | Objective(s): Because of the high total phenolic contents of Feijoa sellowiana
, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice.
Materials and Methods:
Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana
leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used.
Results
: Both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (P 0.05). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (P |
| first_indexed | 2024-12-17T10:18:00Z |
| format | Article |
| id | doaj.art-2443b346a210494291176bfeccf90bbc |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-17T10:18:00Z |
| publishDate | 2014-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-2443b346a210494291176bfeccf90bbc2022-12-21T21:52:52ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742014-01-0117169722159Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in miceMohammad Karami0Faezeh Karimian Nokabadi1Mohammad Ali Ebrahimzadeh2Farshad Naghshvar3Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, IranDepartment of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, IranDepartment of Chemistry, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, IranDepartment of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari, IranObjective(s): Because of the high total phenolic contents of Feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice. Materials and Methods: Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used. Results : Both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (P 0.05). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (Phttp://ijbms.mums.ac.ir/pdf_2159_e11f36271ecbbe0510efc3d2918fcea9.htmlFeijoa sellowiana Kidney glutathione MDMA Nephrotoxicity |
| spellingShingle | Mohammad Karami Faezeh Karimian Nokabadi Mohammad Ali Ebrahimzadeh Farshad Naghshvar Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice Iranian Journal of Basic Medical Sciences Feijoa sellowiana Kidney glutathione MDMA Nephrotoxicity |
| title | Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice |
| title_full | Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice |
| title_fullStr | Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice |
| title_full_unstemmed | Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice |
| title_short | Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice |
| title_sort | nephroprotective effects of feijoa sellowiana leaves extract on renal injury induced by acute dose of ecstasy mdma in mice |
| topic | Feijoa sellowiana Kidney glutathione MDMA Nephrotoxicity |
| url | http://ijbms.mums.ac.ir/pdf_2159_e11f36271ecbbe0510efc3d2918fcea9.html |
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