Recanalization rate of proximal deep venous thrombosis related to therapeutic modality during six months follow-up
Aim To evaluate the efficacy (rate of recanalization) of therapy with novel oral anticoagulants (NOAC; rivaroxaban, apixaban) compared to conventional treatment (low molecular weight heparin - LMWH and vitamin K antagonist) in the treatment of deep vein thrombosis (DVT) of the proximal segments of l...
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| Format: | Article |
| Language: | English |
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Medical Association of Zenica-Doboj Canton
2022-08-01
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| Series: | Medicinski Glasnik |
| Subjects: | |
| Online Access: | https://ljkzedo.ba/mgpdf/mg37/02_Begic_1451_A.pdf |
| _version_ | 1797739319380672512 |
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| author | Alden Begić Edin Begić Mirza Dilić Svjetlana Loga-Zec Nermina Babić Refet Gojak Armin Šljivo |
| author_facet | Alden Begić Edin Begić Mirza Dilić Svjetlana Loga-Zec Nermina Babić Refet Gojak Armin Šljivo |
| author_sort | Alden Begić |
| collection | DOAJ |
| description | Aim To evaluate the efficacy (rate of recanalization) of therapy with novel oral anticoagulants (NOAC; rivaroxaban, apixaban) compared to conventional treatment (low molecular weight heparin - LMWH and vitamin K antagonist) in the treatment of deep vein thrombosis (DVT) of the proximal segments of lower extremities.
Methods The first group consisted of patients diagnosed with DVT and treated with NOAC (n = 100), while the second group consisted of patients diagnosed with DVT, who were treated by conventional treatment (low molecular weight heparin and vitamin K antagonists) (n = 100). In the first group, NOAC was included in the initial treatment. Patients in the second group were treated with LMWH for four days, and on the fifth day vitamin K antagonist was included in therapy, international ratio (INR) was titrated to therapeutic values (2.0-3.0), and then low molecular weight heparin was excluded from the therapy. Results There was a statistically significant difference in the estimated values of free lumen of the blood vessel between the examined groups after 30 days (p=0.0001), after 90 days (p=0.0001) and after 180 days (p=0.0001). After 180 days, the average free lumen values in the NOAC group were 85% (81-89%), which was significantly higher than the free lumen values in the second group, 73% (69-79%). Conclusion The use of NOAC represents more efficient treatment of DVT comparing to vitamin K antagonists. |
| first_indexed | 2024-03-12T13:55:37Z |
| format | Article |
| id | doaj.art-2445efc497844acfaaf7a2c0401fdc6a |
| institution | Directory Open Access Journal |
| issn | 1840-0132 1840-2445 |
| language | English |
| last_indexed | 2024-03-12T13:55:37Z |
| publishDate | 2022-08-01 |
| publisher | Medical Association of Zenica-Doboj Canton |
| record_format | Article |
| series | Medicinski Glasnik |
| spelling | doaj.art-2445efc497844acfaaf7a2c0401fdc6a2023-08-22T14:32:23ZengMedical Association of Zenica-Doboj CantonMedicinski Glasnik1840-01321840-24452022-08-0119213413910.17392/1451-22Recanalization rate of proximal deep venous thrombosis related to therapeutic modality during six months follow-upAlden Begić0Edin Begić1Mirza Dilić2Svjetlana Loga-Zec3Nermina Babić4Refet Gojak5Armin Šljivo6Department of Angiology, Clinic for Heart, Blood Vessel and Rheumatic Diseases, Clinical Centre University of SarajevoDepartment of Cardiology, General Hospital “Prim.dr Abdulah Nakaš“; Department of Pharmacology, School of Medicine, Sarajevo School of Science and TechnologyDepartment of Science, School of Medicine, University of SarajevoDepartment of Pharmacology, School of Medicine, University of SarajevoDepartment of Physiology, School of Medicine, University of SarajevoClinic for Infectious Diseases, Clinical Centre University of SarajevoEmergency Medicine Department of Canton Sarajevo; Sarajevo, Bosnia and HerzegovinaAim To evaluate the efficacy (rate of recanalization) of therapy with novel oral anticoagulants (NOAC; rivaroxaban, apixaban) compared to conventional treatment (low molecular weight heparin - LMWH and vitamin K antagonist) in the treatment of deep vein thrombosis (DVT) of the proximal segments of lower extremities. Methods The first group consisted of patients diagnosed with DVT and treated with NOAC (n = 100), while the second group consisted of patients diagnosed with DVT, who were treated by conventional treatment (low molecular weight heparin and vitamin K antagonists) (n = 100). In the first group, NOAC was included in the initial treatment. Patients in the second group were treated with LMWH for four days, and on the fifth day vitamin K antagonist was included in therapy, international ratio (INR) was titrated to therapeutic values (2.0-3.0), and then low molecular weight heparin was excluded from the therapy. Results There was a statistically significant difference in the estimated values of free lumen of the blood vessel between the examined groups after 30 days (p=0.0001), after 90 days (p=0.0001) and after 180 days (p=0.0001). After 180 days, the average free lumen values in the NOAC group were 85% (81-89%), which was significantly higher than the free lumen values in the second group, 73% (69-79%). Conclusion The use of NOAC represents more efficient treatment of DVT comparing to vitamin K antagonists.https://ljkzedo.ba/mgpdf/mg37/02_Begic_1451_A.pdfanticoagulantstherapeuticsveins |
| spellingShingle | Alden Begić Edin Begić Mirza Dilić Svjetlana Loga-Zec Nermina Babić Refet Gojak Armin Šljivo Recanalization rate of proximal deep venous thrombosis related to therapeutic modality during six months follow-up Medicinski Glasnik anticoagulants therapeutics veins |
| title | Recanalization rate of proximal deep venous thrombosis related to therapeutic modality during six months follow-up |
| title_full | Recanalization rate of proximal deep venous thrombosis related to therapeutic modality during six months follow-up |
| title_fullStr | Recanalization rate of proximal deep venous thrombosis related to therapeutic modality during six months follow-up |
| title_full_unstemmed | Recanalization rate of proximal deep venous thrombosis related to therapeutic modality during six months follow-up |
| title_short | Recanalization rate of proximal deep venous thrombosis related to therapeutic modality during six months follow-up |
| title_sort | recanalization rate of proximal deep venous thrombosis related to therapeutic modality during six months follow up |
| topic | anticoagulants therapeutics veins |
| url | https://ljkzedo.ba/mgpdf/mg37/02_Begic_1451_A.pdf |
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