Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas
We isolated a new ellagitannin, davicratinic acid A (5), together with four known ellagitannins, davidiin (1), granatin A (2), pedunculagin (3), and 3-O-galloylgranatin A (4), from an aqueous acetone extract of dried Davidia involucrata leaves. The known ellagitannins were identified based on spectr...
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MDPI AG
2017-03-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/22/3/470 |
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| author | Yuuki Shimozu Yuriko Kimura Akari Esumi Hiroe Aoyama Teruo Kuroda Hiroshi Sakagami Tsutomu Hatano |
| author_facet | Yuuki Shimozu Yuriko Kimura Akari Esumi Hiroe Aoyama Teruo Kuroda Hiroshi Sakagami Tsutomu Hatano |
| author_sort | Yuuki Shimozu |
| collection | DOAJ |
| description | We isolated a new ellagitannin, davicratinic acid A (5), together with four known ellagitannins, davidiin (1), granatin A (2), pedunculagin (3), and 3-O-galloylgranatin A (4), from an aqueous acetone extract of dried Davidia involucrata leaves. The known ellagitannins were identified based on spectroscopic data. The structure of davicratinic acid A (5), a monomeric ellagitannin possessing a unique, skew-boat glucopyranose core, was established based on spectroscopic data. Additionally, we examined the effects of several tannins with good yields from this plant on drug-resistant bacteria and human oral squamous cell carcinomas, and found that davidiin (1) exhibited the most potent antibacterial and antitumor properties among the tannins examined. |
| first_indexed | 2024-04-12T13:26:00Z |
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| id | doaj.art-24466a40a02348e7b31a0b1fa9d1ca6e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T13:26:00Z |
| publishDate | 2017-03-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-24466a40a02348e7b31a0b1fa9d1ca6e2022-12-22T03:31:18ZengMDPI AGMolecules1420-30492017-03-0122347010.3390/molecules22030470molecules22030470Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell CarcinomasYuuki Shimozu0Yuriko Kimura1Akari Esumi2Hiroe Aoyama3Teruo Kuroda4Hiroshi Sakagami5Tsutomu Hatano6Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, JapanGraduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, JapanGraduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, JapanGraduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, JapanDepartment of Molecular Microbiology and Biotechnology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDivision of Pharmacology, Department of Diagnostic and Therapeutic Sciences, School of Dentistry, Meikai University, Saitama 350-0283, JapanGraduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, JapanWe isolated a new ellagitannin, davicratinic acid A (5), together with four known ellagitannins, davidiin (1), granatin A (2), pedunculagin (3), and 3-O-galloylgranatin A (4), from an aqueous acetone extract of dried Davidia involucrata leaves. The known ellagitannins were identified based on spectroscopic data. The structure of davicratinic acid A (5), a monomeric ellagitannin possessing a unique, skew-boat glucopyranose core, was established based on spectroscopic data. Additionally, we examined the effects of several tannins with good yields from this plant on drug-resistant bacteria and human oral squamous cell carcinomas, and found that davidiin (1) exhibited the most potent antibacterial and antitumor properties among the tannins examined.http://www.mdpi.com/1420-3049/22/3/470Davidia involucrataellagitanninanti-bacterial effectantitumor effectdavicratinic acid A |
| spellingShingle | Yuuki Shimozu Yuriko Kimura Akari Esumi Hiroe Aoyama Teruo Kuroda Hiroshi Sakagami Tsutomu Hatano Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas Molecules Davidia involucrata ellagitannin anti-bacterial effect antitumor effect davicratinic acid A |
| title | Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas |
| title_full | Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas |
| title_fullStr | Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas |
| title_full_unstemmed | Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas |
| title_short | Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas |
| title_sort | ellagitannins of davidia involucrata i structure of davicratinic acid a and effects of davidia tannins on drug resistant bacteria and human oral squamous cell carcinomas |
| topic | Davidia involucrata ellagitannin anti-bacterial effect antitumor effect davicratinic acid A |
| url | http://www.mdpi.com/1420-3049/22/3/470 |
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