Detection and Analysis of EGFR and KRAS Mutations in the Patients with Lung Squamous Cell Carcinomas
Background and objective Activating mutations in epidermal growth factor receptor (EGFR) and KRAS are important markers in non-small cell lung cancer. However, EGFR and KRAS gene mutations in lung squamous cell carcinoma are rarely reported. The aim of this study was to analyze EGFR and KRAS gene mu...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2015-10-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2015.10.04 |
| _version_ | 1819072525516144640 |
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| author | Hui ZHANG Xinjie YANG Na QIN Xi LI Huiyi YANG Jingying NONG Jialin LV Yuhua WU Quan ZHANG Xinyong ZHANG Jinghui WANG Dan SU Shucai ZHANG |
| author_facet | Hui ZHANG Xinjie YANG Na QIN Xi LI Huiyi YANG Jingying NONG Jialin LV Yuhua WU Quan ZHANG Xinyong ZHANG Jinghui WANG Dan SU Shucai ZHANG |
| author_sort | Hui ZHANG |
| collection | DOAJ |
| description | Background and objective Activating mutations in epidermal growth factor receptor (EGFR) and KRAS are important markers in non-small cell lung cancer. However, EGFR and KRAS gene mutations in lung squamous cell carcinoma are rarely reported. The aim of this study was to analyze EGFR and KRAS gene mutation rate and their relationship with clinical features in patients with lung squamous cell carcinomas. Methods A total of 139 patients undergoing treatment for naïve lung squamous cell carcinomas with tumor tissue samples available for testing were recruited. EGFR and KRAS mutation statuses of the tumor samples were detected using a mutant enriched liquid chip. Results Of the 139 cases of lung squamous cell carcinoma, EGFR mutations were detected in 25 cases (18%), KRAS mutations were detected in 7 cases (5%), and the presence of both EGFR and KRAS mutations was detected in 1 case (0.7%). EGFR mutations occurred more often in females than in males (33.3% vs 16.5%) and in patients that never smoked than in those who smoke (29.6% vs 16.1%). However, the difference did not reach statistical significance (P>0.05). No significant differences were observed in age, stage, and different biopsy type. KRAS mutations occurred more often in males than in females (5.5% vs 0%), but the difference did not reach statistical significance (P>0.05). No significant differences were observed in age, stage, different biopsy type, and smoking status (P>0.05). Conclusion EGFR and KRAS mutations were low in lung squamous cell carcinomas, and had no significant correlation with clinical features. Before using tyrosine kinase inhibitor targeted therapy, EGFR and KRAS mutations should be detected in patients with lung squamous cell carcinomas. |
| first_indexed | 2024-12-21T17:39:07Z |
| format | Article |
| id | doaj.art-2446f747900b4fcdbad345416e15581d |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-21T17:39:07Z |
| publishDate | 2015-10-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-2446f747900b4fcdbad345416e15581d2022-12-21T18:55:40ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872015-10-01181062162510.3779/j.issn.1009-3419.2015.10.04Detection and Analysis of EGFR and KRAS Mutations
in the Patients with Lung Squamous Cell CarcinomasHui ZHANG0Xinjie YANG1Na QIN2Xi LI3Huiyi YANG4Jingying NONG5Jialin LV6Yuhua WU7Quan ZHANG8Xinyong ZHANG9Jinghui WANG10Dan SU11Shucai ZHANG12Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaSurExam Clinical Testing Centre, Guangzhou 510663, ChinaDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaDepartment of Pathology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaBackground and objective Activating mutations in epidermal growth factor receptor (EGFR) and KRAS are important markers in non-small cell lung cancer. However, EGFR and KRAS gene mutations in lung squamous cell carcinoma are rarely reported. The aim of this study was to analyze EGFR and KRAS gene mutation rate and their relationship with clinical features in patients with lung squamous cell carcinomas. Methods A total of 139 patients undergoing treatment for naïve lung squamous cell carcinomas with tumor tissue samples available for testing were recruited. EGFR and KRAS mutation statuses of the tumor samples were detected using a mutant enriched liquid chip. Results Of the 139 cases of lung squamous cell carcinoma, EGFR mutations were detected in 25 cases (18%), KRAS mutations were detected in 7 cases (5%), and the presence of both EGFR and KRAS mutations was detected in 1 case (0.7%). EGFR mutations occurred more often in females than in males (33.3% vs 16.5%) and in patients that never smoked than in those who smoke (29.6% vs 16.1%). However, the difference did not reach statistical significance (P>0.05). No significant differences were observed in age, stage, and different biopsy type. KRAS mutations occurred more often in males than in females (5.5% vs 0%), but the difference did not reach statistical significance (P>0.05). No significant differences were observed in age, stage, different biopsy type, and smoking status (P>0.05). Conclusion EGFR and KRAS mutations were low in lung squamous cell carcinomas, and had no significant correlation with clinical features. Before using tyrosine kinase inhibitor targeted therapy, EGFR and KRAS mutations should be detected in patients with lung squamous cell carcinomas.http://dx.doi.org/10.3779/j.issn.1009-3419.2015.10.04Lung neoplasmsEpidermal growth factor receptorKRAS geneMutationSquamous |
| spellingShingle | Hui ZHANG Xinjie YANG Na QIN Xi LI Huiyi YANG Jingying NONG Jialin LV Yuhua WU Quan ZHANG Xinyong ZHANG Jinghui WANG Dan SU Shucai ZHANG Detection and Analysis of EGFR and KRAS Mutations in the Patients with Lung Squamous Cell Carcinomas Chinese Journal of Lung Cancer Lung neoplasms Epidermal growth factor receptor KRAS gene Mutation Squamous |
| title | Detection and Analysis of EGFR and KRAS Mutations
in the Patients with Lung Squamous Cell Carcinomas |
| title_full | Detection and Analysis of EGFR and KRAS Mutations
in the Patients with Lung Squamous Cell Carcinomas |
| title_fullStr | Detection and Analysis of EGFR and KRAS Mutations
in the Patients with Lung Squamous Cell Carcinomas |
| title_full_unstemmed | Detection and Analysis of EGFR and KRAS Mutations
in the Patients with Lung Squamous Cell Carcinomas |
| title_short | Detection and Analysis of EGFR and KRAS Mutations
in the Patients with Lung Squamous Cell Carcinomas |
| title_sort | detection and analysis of egfr and kras mutations
in the patients with lung squamous cell carcinomas |
| topic | Lung neoplasms Epidermal growth factor receptor KRAS gene Mutation Squamous |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2015.10.04 |
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