Landolphia owariensis Attenuates Alcohol-induced Cerebellar Neurodegeneration: Significance of Neurofilament Protein Alteration in the Purkinje Cells
Background: Alcohol-induced cerebellar neurodegeneration is a neuroadaptation that is associated with chronic alcohol abuse. Conventional drugs have been largely unsatisfactory in preventing neurodegeneration. Yet, multimodal neuro-protective therapeutic agents have been hypothesised to have high th...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2016-12-01
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| Series: | Folia Medica |
| Subjects: | |
| Online Access: | http://www.degruyter.com/view/j/folmed.2016.58.issue-4/folmed-2016-0034/folmed-2016-0034.xml?format=INT |
| _version_ | 1818163666994855936 |
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| author | Oyinbo Charles A. Igbigbi Patrick S. Avwioro Godwin O. |
| author_facet | Oyinbo Charles A. Igbigbi Patrick S. Avwioro Godwin O. |
| author_sort | Oyinbo Charles A. |
| collection | DOAJ |
| description | Background: Alcohol-induced cerebellar neurodegeneration is a neuroadaptation that is associated with chronic alcohol abuse. Conventional drugs have been largely unsatisfactory in preventing neurodegeneration. Yet, multimodal neuro-protective therapeutic agents have been hypothesised to have high therapeutic potential for the treatment of CNS conditions; there is yet a dilemma of how this would be achieved. Contrarily, medicinal botanicals are naturally multimodal in their mechanism of action. |
| first_indexed | 2024-12-11T16:53:12Z |
| format | Article |
| id | doaj.art-244706bfc19e4f19b348c47e794fe165 |
| institution | Directory Open Access Journal |
| issn | 1314-2143 |
| language | English |
| last_indexed | 2024-12-11T16:53:12Z |
| publishDate | 2016-12-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Folia Medica |
| spelling | doaj.art-244706bfc19e4f19b348c47e794fe1652022-12-22T00:58:02ZengPensoft PublishersFolia Medica1314-21432016-12-0158424124910.1515/folmed-2016-0034folmed-2016-0034Landolphia owariensis Attenuates Alcohol-induced Cerebellar Neurodegeneration: Significance of Neurofilament Protein Alteration in the Purkinje CellsOyinbo Charles A.0Igbigbi Patrick S.1Avwioro Godwin O.2 Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Delta State, Nigeria Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Delta State, NigeriaBackground: Alcohol-induced cerebellar neurodegeneration is a neuroadaptation that is associated with chronic alcohol abuse. Conventional drugs have been largely unsatisfactory in preventing neurodegeneration. Yet, multimodal neuro-protective therapeutic agents have been hypothesised to have high therapeutic potential for the treatment of CNS conditions; there is yet a dilemma of how this would be achieved. Contrarily, medicinal botanicals are naturally multimodal in their mechanism of action.http://www.degruyter.com/view/j/folmed.2016.58.issue-4/folmed-2016-0034/folmed-2016-0034.xml?format=INTalcoholismcerebellummedicinal plantnutraceuticalsneuroprotection |
| spellingShingle | Oyinbo Charles A. Igbigbi Patrick S. Avwioro Godwin O. Landolphia owariensis Attenuates Alcohol-induced Cerebellar Neurodegeneration: Significance of Neurofilament Protein Alteration in the Purkinje Cells Folia Medica alcoholism cerebellum medicinal plant nutraceuticals neuroprotection |
| title | Landolphia owariensis Attenuates Alcohol-induced Cerebellar Neurodegeneration: Significance of Neurofilament Protein Alteration in the Purkinje Cells |
| title_full | Landolphia owariensis Attenuates Alcohol-induced Cerebellar Neurodegeneration: Significance of Neurofilament Protein Alteration in the Purkinje Cells |
| title_fullStr | Landolphia owariensis Attenuates Alcohol-induced Cerebellar Neurodegeneration: Significance of Neurofilament Protein Alteration in the Purkinje Cells |
| title_full_unstemmed | Landolphia owariensis Attenuates Alcohol-induced Cerebellar Neurodegeneration: Significance of Neurofilament Protein Alteration in the Purkinje Cells |
| title_short | Landolphia owariensis Attenuates Alcohol-induced Cerebellar Neurodegeneration: Significance of Neurofilament Protein Alteration in the Purkinje Cells |
| title_sort | landolphia owariensis attenuates alcohol induced cerebellar neurodegeneration significance of neurofilament protein alteration in the purkinje cells |
| topic | alcoholism cerebellum medicinal plant nutraceuticals neuroprotection |
| url | http://www.degruyter.com/view/j/folmed.2016.58.issue-4/folmed-2016-0034/folmed-2016-0034.xml?format=INT |
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