COVID-19-associated acute respiratory distress syndrome versus classical acute respiratory distress syndrome (a narrative review)
Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), led to the ongoing global public health crisis. Existing clinical data suggest that COVID-19 patients with acute respiratory distress syndrome (ARDS) have worse outcome...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2021-12-01
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| Series: | Iranian Journal of Microbiology |
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| Online Access: | https://ijm.tums.ac.ir/index.php/ijm/article/view/3095 |
| _version_ | 1818889961614606336 |
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| author | Inna Krynytska Mariya Marushchak Inna Birchenko Alina Dovgalyuk Oleksandr Tokarskyy |
| author_facet | Inna Krynytska Mariya Marushchak Inna Birchenko Alina Dovgalyuk Oleksandr Tokarskyy |
| author_sort | Inna Krynytska |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), led to the ongoing global public health crisis. Existing clinical data suggest that COVID-19 patients with acute respiratory distress syndrome (ARDS) have worse outcomes and increased risk of intensive care unit (ICU) admission. The rapid increase in the numbers of patients requiring ICU care may imply a sudden and major challenge for affected health care systems. In this narrative review, we aim to summarize current knowledge of pathophysiology, clinical and morphological characteristics of COVID-19-associated ARDS and ARDS caused by other factors (classical ARDS) as defined by Berlin criteria, and therefore to elucidate the differences, which can affect clinical management of COVID-19-associated ARDS. Fully understanding the characteristics of COVID-19-associated ARDS will help identify its early progression and tailor the treatment, leading to improved prognosis in severe cases and reduced mortality. The notable mechanisms of COVID-19-associated ARDS include severe pulmonary infiltration/edema and inflammation, leading to impaired alveolar homeostasis, alteration of pulmonary physiology resulting in pulmonary fibrosis, endothelial inflammation and vascular thrombosis. Despite some distinct differences between COVID-19-associated ARDS and classical ARDS as defined by Berlin criteria, general treatment principles, such as lung-protective ventilation and rehabilitation concepts should be applied whenever possible. At the same time, ventilatory settings for COVID-19-associated ARDS require to be adapted in individual cases, depending on respiratory mechanics, recruitability and presentation timing. |
| first_indexed | 2024-12-19T17:17:20Z |
| format | Article |
| id | doaj.art-244ae5f9cce74b699bea9f463901ed7e |
| institution | Directory Open Access Journal |
| issn | 2008-3289 2008-4447 |
| language | English |
| last_indexed | 2024-12-19T17:17:20Z |
| publishDate | 2021-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Microbiology |
| spelling | doaj.art-244ae5f9cce74b699bea9f463901ed7e2022-12-21T20:12:49ZengTehran University of Medical SciencesIranian Journal of Microbiology2008-32892008-44472021-12-01136COVID-19-associated acute respiratory distress syndrome versus classical acute respiratory distress syndrome (a narrative review)Inna Krynytska0Mariya Marushchak1Inna Birchenko2Alina Dovgalyuk3Oleksandr Tokarskyy4Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineDepartment of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineDepartment of Medical Biochemistry, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineDepartment of Histology and Embriology, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineDepartment of Medical Biochemistry, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineCoronavirus disease 2019 (COVID-19), caused by the novel coronavirus, Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), led to the ongoing global public health crisis. Existing clinical data suggest that COVID-19 patients with acute respiratory distress syndrome (ARDS) have worse outcomes and increased risk of intensive care unit (ICU) admission. The rapid increase in the numbers of patients requiring ICU care may imply a sudden and major challenge for affected health care systems. In this narrative review, we aim to summarize current knowledge of pathophysiology, clinical and morphological characteristics of COVID-19-associated ARDS and ARDS caused by other factors (classical ARDS) as defined by Berlin criteria, and therefore to elucidate the differences, which can affect clinical management of COVID-19-associated ARDS. Fully understanding the characteristics of COVID-19-associated ARDS will help identify its early progression and tailor the treatment, leading to improved prognosis in severe cases and reduced mortality. The notable mechanisms of COVID-19-associated ARDS include severe pulmonary infiltration/edema and inflammation, leading to impaired alveolar homeostasis, alteration of pulmonary physiology resulting in pulmonary fibrosis, endothelial inflammation and vascular thrombosis. Despite some distinct differences between COVID-19-associated ARDS and classical ARDS as defined by Berlin criteria, general treatment principles, such as lung-protective ventilation and rehabilitation concepts should be applied whenever possible. At the same time, ventilatory settings for COVID-19-associated ARDS require to be adapted in individual cases, depending on respiratory mechanics, recruitability and presentation timing.https://ijm.tums.ac.ir/index.php/ijm/article/view/3095SARS-CoV-2;COVID-19 pandemic;Respiratory distress syndrome;Respiratory mechanics |
| spellingShingle | Inna Krynytska Mariya Marushchak Inna Birchenko Alina Dovgalyuk Oleksandr Tokarskyy COVID-19-associated acute respiratory distress syndrome versus classical acute respiratory distress syndrome (a narrative review) Iranian Journal of Microbiology SARS-CoV-2; COVID-19 pandemic; Respiratory distress syndrome; Respiratory mechanics |
| title | COVID-19-associated acute respiratory distress syndrome versus classical acute respiratory distress syndrome (a narrative review) |
| title_full | COVID-19-associated acute respiratory distress syndrome versus classical acute respiratory distress syndrome (a narrative review) |
| title_fullStr | COVID-19-associated acute respiratory distress syndrome versus classical acute respiratory distress syndrome (a narrative review) |
| title_full_unstemmed | COVID-19-associated acute respiratory distress syndrome versus classical acute respiratory distress syndrome (a narrative review) |
| title_short | COVID-19-associated acute respiratory distress syndrome versus classical acute respiratory distress syndrome (a narrative review) |
| title_sort | covid 19 associated acute respiratory distress syndrome versus classical acute respiratory distress syndrome a narrative review |
| topic | SARS-CoV-2; COVID-19 pandemic; Respiratory distress syndrome; Respiratory mechanics |
| url | https://ijm.tums.ac.ir/index.php/ijm/article/view/3095 |
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