Specific inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss

Specific inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss

Abstract Elevated osteoclast (OC) activity is a major contributor to inflammatory bone loss (IBL) during chronic inflammatory diseases. However, the specific OC precursors (OCPs) responding to inflammatory cues and the underlying mechanisms leading to IBL are poorly understood. We identified two dis...

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Bibliographic Details
Main Authors: Yaron Meirow, Milena Jovanovic, Yuval Zur, Juliana Habib, Daniele Filippo Colombo, Nira Twaik, Hadas Ashkenazi-Preiser, Kerem Ben-Meir, Ivan Mikula, Or Reuven, Guy Kariv, Leonor Daniel, Saja Baraghithy, Yehuda Klein, Jeroen Krijgsveld, Noam Levaot, Michal Baniyash
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-022-00206-z

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