Assessment of Hyperprolactinemia in Drug Naive Patients with Depression
Introduction: Patients with hyperprolactinemia often present with emotional difficulties, which occasionally persist even after treatment with dopamine agonists. There is an unusual prevalence of hyperprolactinemia in patients with depressive disorder. Prolactin is a hormone of the anterior pitu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2021-04-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/2487/47111_CE[Ra1]_F(SHU)_PF1(AG_SHU)_PFA(KM)_PB(AG_KM)_PN(KM).pdf |
| Summary: | Introduction: Patients with hyperprolactinemia often present
with emotional difficulties, which occasionally persist even
after treatment with dopamine agonists. There is an unusual
prevalence of hyperprolactinemia in patients with depressive
disorder. Prolactin is a hormone of the anterior pituitary and its
secretion is regulated by Thyrotropin-Releasing Hormone (TRH)
and Dopamine. Several studies have shown that antidepressants
that inhibit serotonin reuptake can cause hyperprolactinemia
which in turn leads to several complications like galactorrhoea,
sexual dysfunction and several hormonal imbalances. This
study was envisaged to assess baseline prolactin levels before
administering any antidepressants like Selective Serotonin
Reuptake Inhibitors (SSRIs) in patients with depression.
Aim: To assess serum prolactin level in drug naive patients
with depression attending psychiatric Out Patient Department
(OPD) of a tertiary care hospital and to compare its level with
healthy controls.
Materials and Methods: The present study was a cross-sectional,
descriptive hospital based study. The duration of the study was
12 months. The study was conducted at the Department of
Biochemistry and Psychiatry OPD of College of Medicine and
Sagore Dutta Hospital, Kolkata, West Bengal, India. Forty drug
naive depression patients were selected as cases and 40 age and
sex matched healthy individuals randomly were taken as controls.
Results: A total of 40 Major Depressive Disorder (MDD) patients
were studied with a gender distribution of 10 males (25%) and 30
females (75%), age ranging from 21-50 years with the majority
(90%) of the participants belonging to Hindu community.
Among cases (n=40) Median value of prolactin concentration
was 19.7 ng/mL (Z=-2.879,p=0.004) among controls (n=40)
Median value of prolactin concentration was 13.6 ng/mL.There
was significant positive correlation between HAM-D and serum
Prolactin levels.
Conclusion: There should be restrictive use of SSRI in
hyperprolactinemia in patients suffering from depression. |
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| ISSN: | 2277-8551 2455-6882 |