Control of DNA Replication Initiation by Ubiquitin
Eukaryotic cells divide by accomplishing a program of events in which the replication of the genome is a fundamental part. To ensure all cells have an accurate copy of the genome, DNA replication occurs only once per cell cycle and is controlled by numerous pathways. A key step in this process is th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-09-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/7/10/146 |
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| author | Esperanza Hernández-Carralero Elisa Cabrera Ignacio Alonso-de Vega Santiago Hernández-Pérez Veronique A. J. Smits Raimundo Freire |
| author_facet | Esperanza Hernández-Carralero Elisa Cabrera Ignacio Alonso-de Vega Santiago Hernández-Pérez Veronique A. J. Smits Raimundo Freire |
| author_sort | Esperanza Hernández-Carralero |
| collection | DOAJ |
| description | Eukaryotic cells divide by accomplishing a program of events in which the replication of the genome is a fundamental part. To ensure all cells have an accurate copy of the genome, DNA replication occurs only once per cell cycle and is controlled by numerous pathways. A key step in this process is the initiation of DNA replication in which certain regions of DNA are marked as competent to replicate. Moreover, initiation of DNA replication needs to be coordinated with other cell cycle processes. At the molecular level, initiation of DNA replication relies, among other mechanisms, upon post-translational modifications, including the conjugation and hydrolysis of ubiquitin. An example is the precise control of the levels of the DNA replication initiation protein Cdt1 and its inhibitor Geminin by ubiquitin-mediated proteasomal degradation. This control ensures that DNA replication occurs with the right timing during the cell cycle, thereby avoiding re-replication events. Here, we review the events that involve ubiquitin signalling during DNA replication initiation, and how they are linked to human disease. |
| first_indexed | 2024-03-12T07:28:56Z |
| format | Article |
| id | doaj.art-244f89b056234a95949c4fb57b81d835 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:28:56Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-244f89b056234a95949c4fb57b81d8352023-09-02T21:57:09ZengMDPI AGCells2073-44092018-09-0171014610.3390/cells7100146cells7100146Control of DNA Replication Initiation by UbiquitinEsperanza Hernández-Carralero0Elisa Cabrera1Ignacio Alonso-de Vega2Santiago Hernández-Pérez3Veronique A. J. Smits4Raimundo Freire5Unidad de Investigación, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas, Ofra s/n, 38320 La Laguna, Tenerife, SpainUnidad de Investigación, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas, Ofra s/n, 38320 La Laguna, Tenerife, SpainUnidad de Investigación, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas, Ofra s/n, 38320 La Laguna, Tenerife, SpainUnidad de Investigación, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas, Ofra s/n, 38320 La Laguna, Tenerife, SpainUnidad de Investigación, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas, Ofra s/n, 38320 La Laguna, Tenerife, SpainUnidad de Investigación, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas, Ofra s/n, 38320 La Laguna, Tenerife, SpainEukaryotic cells divide by accomplishing a program of events in which the replication of the genome is a fundamental part. To ensure all cells have an accurate copy of the genome, DNA replication occurs only once per cell cycle and is controlled by numerous pathways. A key step in this process is the initiation of DNA replication in which certain regions of DNA are marked as competent to replicate. Moreover, initiation of DNA replication needs to be coordinated with other cell cycle processes. At the molecular level, initiation of DNA replication relies, among other mechanisms, upon post-translational modifications, including the conjugation and hydrolysis of ubiquitin. An example is the precise control of the levels of the DNA replication initiation protein Cdt1 and its inhibitor Geminin by ubiquitin-mediated proteasomal degradation. This control ensures that DNA replication occurs with the right timing during the cell cycle, thereby avoiding re-replication events. Here, we review the events that involve ubiquitin signalling during DNA replication initiation, and how they are linked to human disease.http://www.mdpi.com/2073-4409/7/10/146ubiquitinDNA replication Initiationubiquitin ligasesubiquitin hydrolasesproteasome |
| spellingShingle | Esperanza Hernández-Carralero Elisa Cabrera Ignacio Alonso-de Vega Santiago Hernández-Pérez Veronique A. J. Smits Raimundo Freire Control of DNA Replication Initiation by Ubiquitin Cells ubiquitin DNA replication Initiation ubiquitin ligases ubiquitin hydrolases proteasome |
| title | Control of DNA Replication Initiation by Ubiquitin |
| title_full | Control of DNA Replication Initiation by Ubiquitin |
| title_fullStr | Control of DNA Replication Initiation by Ubiquitin |
| title_full_unstemmed | Control of DNA Replication Initiation by Ubiquitin |
| title_short | Control of DNA Replication Initiation by Ubiquitin |
| title_sort | control of dna replication initiation by ubiquitin |
| topic | ubiquitin DNA replication Initiation ubiquitin ligases ubiquitin hydrolases proteasome |
| url | http://www.mdpi.com/2073-4409/7/10/146 |
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