EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs

EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs

Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified EP300, a histone acetyltransferase, as a crucial regulator of the epigenetic changes that contribute to fibrosis....

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Bibliographic Details
Main Authors: Karla Rubio, Alejandro Molina-Herrera, Andrea Pérez-González, Hury Viridiana Hernández-Galdámez, Carolina Piña-Vázquez, Tania Araujo-Ramos, Indrabahadur Singh
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
histone acetyltransferase
fibrosis
EMT
TGFβ signaling pathway
intrinsic disorder domains
bromodomain inhibitors
Online Access:https://www.mdpi.com/1422-0067/24/15/12302

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