Bone morphogenetic protein 6 polymorphisms are associated with radiographic progression in ankylosing spondylitis.
Nearly 25 genetic loci associated with susceptibility to ankylosing spondylitis (AS) have been identified by several large studies. However, there have been limited studies to identify the genes associated with radiographic severity of the disease. Thus we investigated which genes involved in bone f...
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| Format: | Article |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4133264?pdf=render |
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| author | Young Bin Joo So-Young Bang Tae-Hwan Kim Seung-Cheol Shim Seunghun Lee Kyung Bin Joo Jong Heon Kim Hye Joon Min Proton Rahman Robert D Inman |
| author_facet | Young Bin Joo So-Young Bang Tae-Hwan Kim Seung-Cheol Shim Seunghun Lee Kyung Bin Joo Jong Heon Kim Hye Joon Min Proton Rahman Robert D Inman |
| author_sort | Young Bin Joo |
| collection | DOAJ |
| description | Nearly 25 genetic loci associated with susceptibility to ankylosing spondylitis (AS) have been identified by several large studies. However, there have been limited studies to identify the genes associated with radiographic severity of the disease. Thus we investigated which genes involved in bone formation pathways might be associated with radiographic severity in AS.A total of 417 Korean AS patients were classified into two groups based on the radiographic severity as defined by the modified Stoke' Ankylosing Spondylitis Spinal Score (mSASSS) system. Severe AS was defined by the presence of syndesmophytes and/or fusion in the lumbar or cervical spine (n = 195). Mild AS was defined by the absence of any syndesmophyte or fusion (n = 170). A total of 251 single nucleotide polymorphisms (SNPs) within 52 genes related to bone formation were selected and genotyped. Odds ratios (OR) and 95% confidence interval (95% CI) were analysed by multivariate logistic regression controlling for age at onset of symptoms, sex, disease duration, and smoking status as covariates.We identified new loci of bone morphogenetic protein 6 (BMP6) associated with radiographic severity in patients with AS that passed false discovery rate threshold. Two SNPs in BMP6 were significantly associated with radiologic severity [rs270378 (OR 1.97, p = 6.74 × 10(-4)) and rs1235192 [OR 1.92, p = 1.17 × 10(-3)]) adjusted by covariates.This is the first study to demonstrate that BMP6 is associated with radiographic severity in AS, supporting the role wingless-type like/BMP pathway on radiographic progression in AS. |
| first_indexed | 2024-12-20T19:54:42Z |
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| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T19:54:42Z |
| publishDate | 2014-01-01 |
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| spelling | doaj.art-2452ec89db594fa6b98fba4300dec4062022-12-21T19:28:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0198e10496610.1371/journal.pone.0104966Bone morphogenetic protein 6 polymorphisms are associated with radiographic progression in ankylosing spondylitis.Young Bin JooSo-Young BangTae-Hwan KimSeung-Cheol ShimSeunghun LeeKyung Bin JooJong Heon KimHye Joon MinProton RahmanRobert D InmanNearly 25 genetic loci associated with susceptibility to ankylosing spondylitis (AS) have been identified by several large studies. However, there have been limited studies to identify the genes associated with radiographic severity of the disease. Thus we investigated which genes involved in bone formation pathways might be associated with radiographic severity in AS.A total of 417 Korean AS patients were classified into two groups based on the radiographic severity as defined by the modified Stoke' Ankylosing Spondylitis Spinal Score (mSASSS) system. Severe AS was defined by the presence of syndesmophytes and/or fusion in the lumbar or cervical spine (n = 195). Mild AS was defined by the absence of any syndesmophyte or fusion (n = 170). A total of 251 single nucleotide polymorphisms (SNPs) within 52 genes related to bone formation were selected and genotyped. Odds ratios (OR) and 95% confidence interval (95% CI) were analysed by multivariate logistic regression controlling for age at onset of symptoms, sex, disease duration, and smoking status as covariates.We identified new loci of bone morphogenetic protein 6 (BMP6) associated with radiographic severity in patients with AS that passed false discovery rate threshold. Two SNPs in BMP6 were significantly associated with radiologic severity [rs270378 (OR 1.97, p = 6.74 × 10(-4)) and rs1235192 [OR 1.92, p = 1.17 × 10(-3)]) adjusted by covariates.This is the first study to demonstrate that BMP6 is associated with radiographic severity in AS, supporting the role wingless-type like/BMP pathway on radiographic progression in AS.http://europepmc.org/articles/PMC4133264?pdf=render |
| spellingShingle | Young Bin Joo So-Young Bang Tae-Hwan Kim Seung-Cheol Shim Seunghun Lee Kyung Bin Joo Jong Heon Kim Hye Joon Min Proton Rahman Robert D Inman Bone morphogenetic protein 6 polymorphisms are associated with radiographic progression in ankylosing spondylitis. PLoS ONE |
| title | Bone morphogenetic protein 6 polymorphisms are associated with radiographic progression in ankylosing spondylitis. |
| title_full | Bone morphogenetic protein 6 polymorphisms are associated with radiographic progression in ankylosing spondylitis. |
| title_fullStr | Bone morphogenetic protein 6 polymorphisms are associated with radiographic progression in ankylosing spondylitis. |
| title_full_unstemmed | Bone morphogenetic protein 6 polymorphisms are associated with radiographic progression in ankylosing spondylitis. |
| title_short | Bone morphogenetic protein 6 polymorphisms are associated with radiographic progression in ankylosing spondylitis. |
| title_sort | bone morphogenetic protein 6 polymorphisms are associated with radiographic progression in ankylosing spondylitis |
| url | http://europepmc.org/articles/PMC4133264?pdf=render |
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