Arsenic in Drinking Water and Incidences of Leukemia and Lymphoma: Implication for Its Dual Effects in Carcinogenicity
Arsenic in drinking water has been recognized as carcinogenic to humans and can cause solid cancers of lung, urinary bladder, and skin. Positive associations have also been reported between arsenic ingestion and cancers of kidney, liver and prostate. Nevertheless, arsenic trioxide has been used succ...
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Frontiers Media S.A.
2022-04-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.863882/full |
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| author | Ming-Hsien Lin Ming-Hsien Lin Chung-Yi Li Ya-Yun Cheng How-Ran Guo How-Ran Guo |
| author_facet | Ming-Hsien Lin Ming-Hsien Lin Chung-Yi Li Ya-Yun Cheng How-Ran Guo How-Ran Guo |
| author_sort | Ming-Hsien Lin |
| collection | DOAJ |
| description | Arsenic in drinking water has been recognized as carcinogenic to humans and can cause solid cancers of lung, urinary bladder, and skin. Positive associations have also been reported between arsenic ingestion and cancers of kidney, liver and prostate. Nevertheless, arsenic trioxide has been used successfully in the treatment of acute promyelocytic leukemia. Therefore, arsenic might play different roles in the carcinogenesis of solid cancers and hematologic malignancies. The relationship between arsenic in drinking water and the incidences of hematologic malignancies has not been fully investigated. We established a cohort of Taiwanese population and assorted 319 townships of Taiwan into two exposure categories using 0.05 mg/L as the cutoff. Then, we linked these data to the Taiwan Cancer Registry and computed standardized incidence ratios (SIRs) of lymphoma and leukemia by sex, exposure category and time period. The trend of changes in the SIRs over time was assessed, from 1981–1990 to 1991–2000 and then to 2001–2010. We found that in both lymphoma and leukemia, the higher exposure category was associated with lower SIRs in both men and women. In terms of time trends, the SIRs in both lymphoma and leukemia showed increasing trends in both sexes, while exposure to arsenic in drinking water decreased over time. The arsenic level in drinking water was negatively associated with the incidences of lymphoma and leukemia in both men and women. This study supports the dual effects of arsenic on carcinogenesis, with a potential protective effect against hematologic malignancies. |
| first_indexed | 2024-04-13T04:21:57Z |
| format | Article |
| id | doaj.art-2454885725ff4f408118b4ee9d8072ef |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-13T04:21:57Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-2454885725ff4f408118b4ee9d8072ef2022-12-22T03:02:41ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-04-011010.3389/fpubh.2022.863882863882Arsenic in Drinking Water and Incidences of Leukemia and Lymphoma: Implication for Its Dual Effects in CarcinogenicityMing-Hsien Lin0Ming-Hsien Lin1Chung-Yi Li2Ya-Yun Cheng3How-Ran Guo4How-Ran Guo5Division of Hematology and Oncology, Department of Internal Medicine, An Nan Hospital, China Medical University, Tainan, TaiwanDepartment of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Public Health, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Environmental Health, T.H. Chan School of Public Health, Harvard University, Boston, MA, United StatesDepartment of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan, TaiwanArsenic in drinking water has been recognized as carcinogenic to humans and can cause solid cancers of lung, urinary bladder, and skin. Positive associations have also been reported between arsenic ingestion and cancers of kidney, liver and prostate. Nevertheless, arsenic trioxide has been used successfully in the treatment of acute promyelocytic leukemia. Therefore, arsenic might play different roles in the carcinogenesis of solid cancers and hematologic malignancies. The relationship between arsenic in drinking water and the incidences of hematologic malignancies has not been fully investigated. We established a cohort of Taiwanese population and assorted 319 townships of Taiwan into two exposure categories using 0.05 mg/L as the cutoff. Then, we linked these data to the Taiwan Cancer Registry and computed standardized incidence ratios (SIRs) of lymphoma and leukemia by sex, exposure category and time period. The trend of changes in the SIRs over time was assessed, from 1981–1990 to 1991–2000 and then to 2001–2010. We found that in both lymphoma and leukemia, the higher exposure category was associated with lower SIRs in both men and women. In terms of time trends, the SIRs in both lymphoma and leukemia showed increasing trends in both sexes, while exposure to arsenic in drinking water decreased over time. The arsenic level in drinking water was negatively associated with the incidences of lymphoma and leukemia in both men and women. This study supports the dual effects of arsenic on carcinogenesis, with a potential protective effect against hematologic malignancies.https://www.frontiersin.org/articles/10.3389/fpubh.2022.863882/fullarsenicincidencelymphomaleukemiacarcinogenesisdrinking water |
| spellingShingle | Ming-Hsien Lin Ming-Hsien Lin Chung-Yi Li Ya-Yun Cheng How-Ran Guo How-Ran Guo Arsenic in Drinking Water and Incidences of Leukemia and Lymphoma: Implication for Its Dual Effects in Carcinogenicity Frontiers in Public Health arsenic incidence lymphoma leukemia carcinogenesis drinking water |
| title | Arsenic in Drinking Water and Incidences of Leukemia and Lymphoma: Implication for Its Dual Effects in Carcinogenicity |
| title_full | Arsenic in Drinking Water and Incidences of Leukemia and Lymphoma: Implication for Its Dual Effects in Carcinogenicity |
| title_fullStr | Arsenic in Drinking Water and Incidences of Leukemia and Lymphoma: Implication for Its Dual Effects in Carcinogenicity |
| title_full_unstemmed | Arsenic in Drinking Water and Incidences of Leukemia and Lymphoma: Implication for Its Dual Effects in Carcinogenicity |
| title_short | Arsenic in Drinking Water and Incidences of Leukemia and Lymphoma: Implication for Its Dual Effects in Carcinogenicity |
| title_sort | arsenic in drinking water and incidences of leukemia and lymphoma implication for its dual effects in carcinogenicity |
| topic | arsenic incidence lymphoma leukemia carcinogenesis drinking water |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.863882/full |
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