Rare Neurologic Disease-Associated Mutations of AIMP1 Are Related with Inhibitory Neuronal Differentiation Which Is Reversed by Ibuprofen

Rare Neurologic Disease-Associated Mutations of AIMP1 Are Related with Inhibitory Neuronal Differentiation Which Is Reversed by Ibuprofen

<b>Background:</b> Hypomyelinating leukodystrophy 3 (HLD3), previously characterized as a congenital diseases associated with oligodendrocyte myelination, is increasingly regarded as primarily affecting neuronal cells. <b>Methods:</b> We used N1E-115 cells as the neuronal cel...

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Bibliographic Details
Main Authors: Yu Takeuchi, Marina Tanaka, Nanako Okura, Yasuyuki Fukui, Ko Noguchi, Yoshihiro Hayashi, Tomohiro Torii, Hiroaki Ooizumi, Katsuya Ohbuchi, Kazushige Mizoguchi, Yuki Miyamoto, Junji Yamauchi
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Medicines
Subjects:
AIMP1
mutation
differentiation
actin
ibuprofen
Online Access:https://www.mdpi.com/2305-6320/7/5/25

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