Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials
Background:. Aging, an inevitable and continuous process in one’s lifetime, has all along been a focus of interest, especially for women, yet photoaging treatment to slow the process remains challenging. Recent studies have demonstrated the potency of topical tretinoin in the treatment of photoaging...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2022-03-01
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| Series: | International Journal of Women's Dermatology |
| Online Access: | http://journals.lww.com/10.1097/JW9.0000000000000003 |
| _version_ | 1811256685901119488 |
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| author | Irma Bernadette S. Sitohang, MD, PhD Wresti Indriatmi Makes, MD, PhD Normalina Sandora, MD, PhD Jose Suryanegara, MD |
| author_facet | Irma Bernadette S. Sitohang, MD, PhD Wresti Indriatmi Makes, MD, PhD Normalina Sandora, MD, PhD Jose Suryanegara, MD |
| author_sort | Irma Bernadette S. Sitohang, MD, PhD |
| collection | DOAJ |
| description | Background:. Aging, an inevitable and continuous process in one’s lifetime, has all along been a focus of interest, especially for women, yet photoaging treatment to slow the process remains challenging. Recent studies have demonstrated the potency of topical tretinoin in the treatment of photoaging. Tretinoin, a metabolite of retinoids, shows prominent efficacy to regulate proliferation and differentiation of epidermal cells and induce new collagen formation.
Objective:. This review aims to study the current evidence on topical tretinoin for photoaging treatment.
Methods:. A systematic search of the literature was performed from Medline, Cochrane Central, Embase, and PubMed databases for published articles in the past 20 years. Only randomized controlled trials investigating tretinoin for photoaging treatment were included in our review.
Results:. A total of 180 studies were initially examined, of which 7 randomized controlled trials were included in this review. Four studies included only women as their participants, while the rest demonstrated women as their majority subjects. All studies that indicated topical tretinoin were safe and well tolerated in all patients. Topical tretinoin dosage varied from 0.025% to 5% while duration of treatment ranged from 3 months up to 24 months. With regard to efficacy, all studies consistently reported that topical tretinoin was efficacious in improving clinical appearance of photoaging in terms of wrinkling, mottled hyperpigmentation, sallowness, and lentigines as early as 1 month and lasted after 24 months.
Limitations:. Different tretinoin formulas used, different outcome parameters, and limited recent studies on topical tretinoin cause lack of uniformity in the evidences.
Conclusion:. Topical tretinoin is a safe and effective therapeutic modality for long-term treatment of photoaging. Further research is required to compare dose-ranging topical tretinoin to other agents to provide the best treatment strategy for photoaged skin. |
| first_indexed | 2024-04-12T17:45:00Z |
| format | Article |
| id | doaj.art-2459fefcec8b43368e444eba39e52a13 |
| institution | Directory Open Access Journal |
| issn | 2352-6475 |
| language | English |
| last_indexed | 2024-04-12T17:45:00Z |
| publishDate | 2022-03-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | International Journal of Women's Dermatology |
| spelling | doaj.art-2459fefcec8b43368e444eba39e52a132022-12-22T03:22:41ZengWolters KluwerInternational Journal of Women's Dermatology2352-64752022-03-0181e00310.1097/JW9.0000000000000003202203000-00010Topical tretinoin for treating photoaging: A systematic review of randomized controlled trialsIrma Bernadette S. Sitohang, MD, PhD0Wresti Indriatmi Makes, MD, PhD1Normalina Sandora, MD, PhD2Jose Suryanegara, MD3a Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesiaa Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesiab Human Reproduction, Infertility and Family Planning, Indonesia Medical Education and Research Institute, Jakarta, Indonesiac Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, IndonesiaBackground:. Aging, an inevitable and continuous process in one’s lifetime, has all along been a focus of interest, especially for women, yet photoaging treatment to slow the process remains challenging. Recent studies have demonstrated the potency of topical tretinoin in the treatment of photoaging. Tretinoin, a metabolite of retinoids, shows prominent efficacy to regulate proliferation and differentiation of epidermal cells and induce new collagen formation. Objective:. This review aims to study the current evidence on topical tretinoin for photoaging treatment. Methods:. A systematic search of the literature was performed from Medline, Cochrane Central, Embase, and PubMed databases for published articles in the past 20 years. Only randomized controlled trials investigating tretinoin for photoaging treatment were included in our review. Results:. A total of 180 studies were initially examined, of which 7 randomized controlled trials were included in this review. Four studies included only women as their participants, while the rest demonstrated women as their majority subjects. All studies that indicated topical tretinoin were safe and well tolerated in all patients. Topical tretinoin dosage varied from 0.025% to 5% while duration of treatment ranged from 3 months up to 24 months. With regard to efficacy, all studies consistently reported that topical tretinoin was efficacious in improving clinical appearance of photoaging in terms of wrinkling, mottled hyperpigmentation, sallowness, and lentigines as early as 1 month and lasted after 24 months. Limitations:. Different tretinoin formulas used, different outcome parameters, and limited recent studies on topical tretinoin cause lack of uniformity in the evidences. Conclusion:. Topical tretinoin is a safe and effective therapeutic modality for long-term treatment of photoaging. Further research is required to compare dose-ranging topical tretinoin to other agents to provide the best treatment strategy for photoaged skin.http://journals.lww.com/10.1097/JW9.0000000000000003 |
| spellingShingle | Irma Bernadette S. Sitohang, MD, PhD Wresti Indriatmi Makes, MD, PhD Normalina Sandora, MD, PhD Jose Suryanegara, MD Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials International Journal of Women's Dermatology |
| title | Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials |
| title_full | Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials |
| title_fullStr | Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials |
| title_full_unstemmed | Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials |
| title_short | Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials |
| title_sort | topical tretinoin for treating photoaging a systematic review of randomized controlled trials |
| url | http://journals.lww.com/10.1097/JW9.0000000000000003 |
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