A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors
Objectives: Hepatitis B virus (HBV) infection remains a global health problem. Risk factors for HBV infection are usually assessed in prevalent rather than incident infections. To identify demographic and behavioral risks associated with incident HBV among South African blood donors. Methods: A case...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224000262 |
| _version_ | 1797263647477596160 |
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| author | Ute Jentsch Marion Vermeulen Karin van den Berg Ronél Swanevelder Darryl Creel Genevieve Jacobs Jennifer Jay Hemingway-Foday Cynthia Nyoni Edward L. Murphy Brian Custer |
| author_facet | Ute Jentsch Marion Vermeulen Karin van den Berg Ronél Swanevelder Darryl Creel Genevieve Jacobs Jennifer Jay Hemingway-Foday Cynthia Nyoni Edward L. Murphy Brian Custer |
| author_sort | Ute Jentsch |
| collection | DOAJ |
| description | Objectives: Hepatitis B virus (HBV) infection remains a global health problem. Risk factors for HBV infection are usually assessed in prevalent rather than incident infections. To identify demographic and behavioral risks associated with incident HBV among South African blood donors. Methods: A case-control study was performed between November 2014 and January 2018. Cases were blood donors testing positive for HBV DNA with or without hepatitis B surface antigen but negative for antibody to hepatitis B core antigen. Participants completed an audio computer-assisted structured interview on exposures during the previous 6 months. Sex-specific multivariable logistic regression yielded independent associations between risks and HBV infection. Results: 56 females and 37 males with incident HBV were compared to 438 female and 439 male controls, respectively. For females, risk factors were accepting money or goods for sex, using agents to prepare one's anus prior to anal sex, penetrating injury, non-Black race, and lower educational status. Men reporting homosexual or bisexual orientation or sex with other men, previous injury, referral for HBV testing, or lack of medical insurance were at increased risk. For both sexes, having more than two male sexual partners increased risk. Conclusions: Sexual behaviors predominated over parenteral exposures as risks for incident HBV in both female and male blood donors. |
| first_indexed | 2024-03-07T14:29:48Z |
| format | Article |
| id | doaj.art-245a86b71bf8422b8c8dc1291d821290 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-25T00:16:20Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-245a86b71bf8422b8c8dc1291d8212902024-03-13T04:45:00ZengElsevierInternational Journal of Infectious Diseases1201-97122024-04-01141106958A case-control study of risk factors for incident hepatitis B virus infection in South African blood donorsUte Jentsch0Marion Vermeulen1Karin van den Berg2Ronél Swanevelder3Darryl Creel4Genevieve Jacobs5Jennifer Jay Hemingway-Foday6Cynthia Nyoni7Edward L. Murphy8Brian Custer9The South African National Blood Service, Johannesburg, South Africa; Corresponding author.The South African National Blood Service, Johannesburg, South Africa; University of the Free State, Bloemfontein, South AfricaThe South African National Blood Service, Johannesburg, South Africa; University of the Free State, Bloemfontein, South AfricaThe South African National Blood Service, Johannesburg, South AfricaRTI International, Rockville, USAThe South African National Blood Service, Johannesburg, South AfricaRTI International, Rockville, USAThe South African National Blood Service, Johannesburg, South AfricaUniversity of California San Francisco, San Francisco, USA; Vitalant Research Institute, San Francisco, USAVitalant Research Institute, San Francisco, USA; University of California San Francisco, San Francisco, USAObjectives: Hepatitis B virus (HBV) infection remains a global health problem. Risk factors for HBV infection are usually assessed in prevalent rather than incident infections. To identify demographic and behavioral risks associated with incident HBV among South African blood donors. Methods: A case-control study was performed between November 2014 and January 2018. Cases were blood donors testing positive for HBV DNA with or without hepatitis B surface antigen but negative for antibody to hepatitis B core antigen. Participants completed an audio computer-assisted structured interview on exposures during the previous 6 months. Sex-specific multivariable logistic regression yielded independent associations between risks and HBV infection. Results: 56 females and 37 males with incident HBV were compared to 438 female and 439 male controls, respectively. For females, risk factors were accepting money or goods for sex, using agents to prepare one's anus prior to anal sex, penetrating injury, non-Black race, and lower educational status. Men reporting homosexual or bisexual orientation or sex with other men, previous injury, referral for HBV testing, or lack of medical insurance were at increased risk. For both sexes, having more than two male sexual partners increased risk. Conclusions: Sexual behaviors predominated over parenteral exposures as risks for incident HBV in both female and male blood donors.http://www.sciencedirect.com/science/article/pii/S1201971224000262Hepatitis B virusTransfusionBlood donorsRisk factors |
| spellingShingle | Ute Jentsch Marion Vermeulen Karin van den Berg Ronél Swanevelder Darryl Creel Genevieve Jacobs Jennifer Jay Hemingway-Foday Cynthia Nyoni Edward L. Murphy Brian Custer A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors International Journal of Infectious Diseases Hepatitis B virus Transfusion Blood donors Risk factors |
| title | A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors |
| title_full | A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors |
| title_fullStr | A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors |
| title_full_unstemmed | A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors |
| title_short | A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors |
| title_sort | case control study of risk factors for incident hepatitis b virus infection in south african blood donors |
| topic | Hepatitis B virus Transfusion Blood donors Risk factors |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224000262 |
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