Pediatric Dosing and Body Size in Biotherapeutics
Although pediatric doses for biotherapeutics are often based on patients' body weight (mg/kg) or body surface area (mg/m2), linear body size dose adjustment is highly empirical. Growth and maturity are also important factors that affect the absorption, distribution, metabolism and excretion (AD...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-12-01
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| Series: | Pharmaceutics |
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| Online Access: | http://www.mdpi.com/1999-4923/2/4/389/ |
| _version_ | 1828115259050688512 |
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| author | Hartmut Derendorf Rong Shi |
| author_facet | Hartmut Derendorf Rong Shi |
| author_sort | Hartmut Derendorf |
| collection | DOAJ |
| description | Although pediatric doses for biotherapeutics are often based on patients' body weight (mg/kg) or body surface area (mg/m2), linear body size dose adjustment is highly empirical. Growth and maturity are also important factors that affect the absorption, distribution, metabolism and excretion (ADME) of biologics in pediatrics. The complexity of the factors involved in pediatric pharmacokinetics lends to the reconsideration of body size based dose adjustment. A proper dosing adjustment for pediatrics should also provide less intersubject variability in the pharmacokinetics and/or pharmacodynamics of the product compared with no dose adjustment. Biological proteins and peptides generally share the same pharmacokinetic principle with small molecules, but the underlying mechanism can be very different. Here, pediatric and adult pharmacokinetic parameters are compared and summarized for selected biotherapeutics. The effect of body size on the pediatric pharmacokinetics for these biological products is discussed in the current review. |
| first_indexed | 2024-04-11T12:37:27Z |
| format | Article |
| id | doaj.art-245bf80d163740979a2ec2066517e9eb |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T12:37:27Z |
| publishDate | 2010-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-245bf80d163740979a2ec2066517e9eb2022-12-22T04:23:35ZengMDPI AGPharmaceutics1999-49232010-12-012438941810.3390/pharmaceutics2040389Pediatric Dosing and Body Size in BiotherapeuticsHartmut DerendorfRong ShiAlthough pediatric doses for biotherapeutics are often based on patients' body weight (mg/kg) or body surface area (mg/m2), linear body size dose adjustment is highly empirical. Growth and maturity are also important factors that affect the absorption, distribution, metabolism and excretion (ADME) of biologics in pediatrics. The complexity of the factors involved in pediatric pharmacokinetics lends to the reconsideration of body size based dose adjustment. A proper dosing adjustment for pediatrics should also provide less intersubject variability in the pharmacokinetics and/or pharmacodynamics of the product compared with no dose adjustment. Biological proteins and peptides generally share the same pharmacokinetic principle with small molecules, but the underlying mechanism can be very different. Here, pediatric and adult pharmacokinetic parameters are compared and summarized for selected biotherapeutics. The effect of body size on the pediatric pharmacokinetics for these biological products is discussed in the current review.http://www.mdpi.com/1999-4923/2/4/389/pediatricdosingproteinspeptides |
| spellingShingle | Hartmut Derendorf Rong Shi Pediatric Dosing and Body Size in Biotherapeutics Pharmaceutics pediatric dosing proteins peptides |
| title | Pediatric Dosing and Body Size in Biotherapeutics |
| title_full | Pediatric Dosing and Body Size in Biotherapeutics |
| title_fullStr | Pediatric Dosing and Body Size in Biotherapeutics |
| title_full_unstemmed | Pediatric Dosing and Body Size in Biotherapeutics |
| title_short | Pediatric Dosing and Body Size in Biotherapeutics |
| title_sort | pediatric dosing and body size in biotherapeutics |
| topic | pediatric dosing proteins peptides |
| url | http://www.mdpi.com/1999-4923/2/4/389/ |
| work_keys_str_mv | AT hartmutderendorf pediatricdosingandbodysizeinbiotherapeutics AT rongshi pediatricdosingandbodysizeinbiotherapeutics |