Alkaptonuric Arthropathy with Periprosthetic Fracture: A Case Report
Alkaptonuria or Ochronosis is an autosomal recessive congenital metabolic error due to absence of enzyme homogentisic acid oxidase. Recently, we had an opportunity to diagnose this condition in one of our patients. An old aged man developed a pathological fracture of femur after a trivial fall at...
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JCDR Research and Publications Private Limited
2014-03-01
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| Online Access: | https://jcdr.net/articles/PDF/4157/65-%207740_E(C)_F(T)_PF1(PAK)_PFA(AK)_PF2(PN).pdf |
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| author | S. Durgaprasad Hegde Siva Ranjan D. Muralidhar B.M. Epari Sanjeeva Rao P.S.B. Hussain |
| author_facet | S. Durgaprasad Hegde Siva Ranjan D. Muralidhar B.M. Epari Sanjeeva Rao P.S.B. Hussain |
| author_sort | S. Durgaprasad Hegde |
| collection | DOAJ |
| description | Alkaptonuria or Ochronosis is an autosomal recessive congenital metabolic error due to absence of enzyme homogentisic acid oxidase.
Recently, we had an opportunity to diagnose this condition in one of our patients. An old aged man developed a pathological fracture of femur
after a trivial fall at home. He was diagnosed to have intracapsular fracture neck of femur. Intraoperatively we noticed blackish discoloration
of femoral head which lead us to investigate the case for alkaptonuria. Hemiarthroplasty was done with Austin moore prosthesis. Patient
had cutaneous pigmentation and gross arthritic changes at multiple joints including spine. After one and half year patient developed a
periprosthetic fracture of the femur for which open reduction and internal fixation was done. A periprosthetic fracture in ochronotic patient
has never been reported till date which makes it a rarer entity. This article presents the clinico-radiologic manifestations of the case with
surgical management and a follow up of two years. |
| first_indexed | 2024-12-10T19:21:43Z |
| format | Article |
| id | doaj.art-245e569cdad64c29a76190fc2e759bf9 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-10T19:21:43Z |
| publishDate | 2014-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-245e569cdad64c29a76190fc2e759bf92022-12-22T01:36:27ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-03-018317617810.7860/JCDR/2014/7740.4157Alkaptonuric Arthropathy with Periprosthetic Fracture: A Case ReportS. Durgaprasad Hegde0Siva Ranjan D.1Muralidhar B.M.2Epari Sanjeeva Rao3P.S.B. Hussain4Senior Resident, Department of Orthopaedics, Konaseema Institute of Medical Sciences, Chaitanya Nagar, Amalapuram, India.Assistant Professor, Department of Pathology, Konaseema Institute of Medical Sciences, Chaitanya Nagar, Amalapuram, India.Assistant Professor, Department of Orthopaedics, Konaseema Institute of Medical Sciences, Chaitanya Nagar, Amalapuram, India.Professor, Department of Pathology, Konaseema Institute of Medical Sciences, Chaitanya Nagar, Amalapuram, India.Senior Resident, Department of Orthopaedics, Konaseema Institute of Medical Sciences, Chaitanya Nagar, Amalapuram, India.Alkaptonuria or Ochronosis is an autosomal recessive congenital metabolic error due to absence of enzyme homogentisic acid oxidase. Recently, we had an opportunity to diagnose this condition in one of our patients. An old aged man developed a pathological fracture of femur after a trivial fall at home. He was diagnosed to have intracapsular fracture neck of femur. Intraoperatively we noticed blackish discoloration of femoral head which lead us to investigate the case for alkaptonuria. Hemiarthroplasty was done with Austin moore prosthesis. Patient had cutaneous pigmentation and gross arthritic changes at multiple joints including spine. After one and half year patient developed a periprosthetic fracture of the femur for which open reduction and internal fixation was done. A periprosthetic fracture in ochronotic patient has never been reported till date which makes it a rarer entity. This article presents the clinico-radiologic manifestations of the case with surgical management and a follow up of two years.https://jcdr.net/articles/PDF/4157/65-%207740_E(C)_F(T)_PF1(PAK)_PFA(AK)_PF2(PN).pdfochronosishomogentisic oxidasepathological fractureaustin moore prosthesis |
| spellingShingle | S. Durgaprasad Hegde Siva Ranjan D. Muralidhar B.M. Epari Sanjeeva Rao P.S.B. Hussain Alkaptonuric Arthropathy with Periprosthetic Fracture: A Case Report Journal of Clinical and Diagnostic Research ochronosis homogentisic oxidase pathological fracture austin moore prosthesis |
| title | Alkaptonuric Arthropathy with Periprosthetic Fracture: A Case Report |
| title_full | Alkaptonuric Arthropathy with Periprosthetic Fracture: A Case Report |
| title_fullStr | Alkaptonuric Arthropathy with Periprosthetic Fracture: A Case Report |
| title_full_unstemmed | Alkaptonuric Arthropathy with Periprosthetic Fracture: A Case Report |
| title_short | Alkaptonuric Arthropathy with Periprosthetic Fracture: A Case Report |
| title_sort | alkaptonuric arthropathy with periprosthetic fracture a case report |
| topic | ochronosis homogentisic oxidase pathological fracture austin moore prosthesis |
| url | https://jcdr.net/articles/PDF/4157/65-%207740_E(C)_F(T)_PF1(PAK)_PFA(AK)_PF2(PN).pdf |
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