The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell
Abstract The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical transducer (MET) channel is the entryway for the so...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-44230-x |
| _version_ | 1797349834070425600 |
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| author | Jeong Han Lee Maria C. Perez-Flores Seojin Park Hyo Jeong Kim Yingying Chen Mincheol Kang Jennifer Kersigo Jinsil Choi Phung N. Thai Ryan L. Woltz Dolores Columba Perez-Flores Guy Perkins Choong-Ryoul Sihn Pauline Trinh Xiao-Dong Zhang Padmini Sirish Yao Dong Wayne Wei Feng Isaac N. Pessah Rose E. Dixon Bernd Sokolowski Bernd Fritzsch Nipavan Chiamvimonvat Ebenezer N. Yamoah |
| author_facet | Jeong Han Lee Maria C. Perez-Flores Seojin Park Hyo Jeong Kim Yingying Chen Mincheol Kang Jennifer Kersigo Jinsil Choi Phung N. Thai Ryan L. Woltz Dolores Columba Perez-Flores Guy Perkins Choong-Ryoul Sihn Pauline Trinh Xiao-Dong Zhang Padmini Sirish Yao Dong Wayne Wei Feng Isaac N. Pessah Rose E. Dixon Bernd Sokolowski Bernd Fritzsch Nipavan Chiamvimonvat Ebenezer N. Yamoah |
| author_sort | Jeong Han Lee |
| collection | DOAJ |
| description | Abstract The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical transducer (MET) channel is the entryway for the sound-balance-brain interface, but the channel-complex composition is not entirely known. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as MET-complex components. The Pz channels, expressed in HC stereocilia, and cell lines are co-localized and co-assembled with MET complex partners. Mice expressing non-functional Pz1 and Pz2 at the ROSA26 locus have impaired auditory and vestibular traits that can only be explained if the Pzs are integral to the MET complex. We suggest that Pz subunits constitute part of the MET complex and that interactions with other MET complex components yield functional MET units to generate HC MET currents. |
| first_indexed | 2024-03-08T12:36:11Z |
| format | Article |
| id | doaj.art-2460730132124905aa50c50a2faffa24 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-08T12:36:11Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2460730132124905aa50c50a2faffa242024-01-21T12:26:44ZengNature PortfolioNature Communications2041-17232024-01-0115111710.1038/s41467-023-44230-xThe Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cellJeong Han Lee0Maria C. Perez-Flores1Seojin Park2Hyo Jeong Kim3Yingying Chen4Mincheol Kang5Jennifer Kersigo6Jinsil Choi7Phung N. Thai8Ryan L. Woltz9Dolores Columba Perez-Flores10Guy Perkins11Choong-Ryoul Sihn12Pauline Trinh13Xiao-Dong Zhang14Padmini Sirish15Yao Dong16Wayne Wei Feng17Isaac N. Pessah18Rose E. Dixon19Bernd Sokolowski20Bernd Fritzsch21Nipavan Chiamvimonvat22Ebenezer N. Yamoah23Department of Physiology and Cell Biology, School of Medicine, University of NevadaDepartment of Physiology and Cell Biology, School of Medicine, University of NevadaDepartment of Physiology and Cell Biology, School of Medicine, University of NevadaDepartment of Physiology and Cell Biology, School of Medicine, University of NevadaDepartment of Physiology and Cell Biology, School of Medicine, University of NevadaDepartment of Physiology and Cell Biology, School of Medicine, University of NevadaDepartment of Biology, University of IowaDepartment of Physiology and Cell Biology, School of Medicine, University of NevadaDivision of Cardiovascular Medicine, Department of Internal Medicine, University of CaliforniaDivision of Cardiovascular Medicine, Department of Internal Medicine, University of CaliforniaDepartment of Physiology and Cell Biology, School of Medicine, University of NevadaNational Center for Microscopy and Imaging Research, University of California San DiegoDepartment of Physiology and Cell Biology, School of Medicine, University of NevadaDivision of Cardiovascular Medicine, Department of Internal Medicine, University of CaliforniaDivision of Cardiovascular Medicine, Department of Internal Medicine, University of CaliforniaDivision of Cardiovascular Medicine, Department of Internal Medicine, University of CaliforniaDepartment of Molecular Biosciences, School of Veterinary Medicine, University of CaliforniaDepartment of Molecular Biosciences, School of Veterinary Medicine, University of CaliforniaDepartment of Molecular Biosciences, School of Veterinary Medicine, University of CaliforniaDepartment of Physiology & Membrane Biology, Tupper HallDepartment of Otolaryngology-Head and Neck Surgery, Morsani College of Medicine, University of South FloridaDepartment of Biology, University of IowaDivision of Cardiovascular Medicine, Department of Internal Medicine, University of CaliforniaDepartment of Physiology and Cell Biology, School of Medicine, University of NevadaAbstract The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical transducer (MET) channel is the entryway for the sound-balance-brain interface, but the channel-complex composition is not entirely known. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as MET-complex components. The Pz channels, expressed in HC stereocilia, and cell lines are co-localized and co-assembled with MET complex partners. Mice expressing non-functional Pz1 and Pz2 at the ROSA26 locus have impaired auditory and vestibular traits that can only be explained if the Pzs are integral to the MET complex. We suggest that Pz subunits constitute part of the MET complex and that interactions with other MET complex components yield functional MET units to generate HC MET currents.https://doi.org/10.1038/s41467-023-44230-x |
| spellingShingle | Jeong Han Lee Maria C. Perez-Flores Seojin Park Hyo Jeong Kim Yingying Chen Mincheol Kang Jennifer Kersigo Jinsil Choi Phung N. Thai Ryan L. Woltz Dolores Columba Perez-Flores Guy Perkins Choong-Ryoul Sihn Pauline Trinh Xiao-Dong Zhang Padmini Sirish Yao Dong Wayne Wei Feng Isaac N. Pessah Rose E. Dixon Bernd Sokolowski Bernd Fritzsch Nipavan Chiamvimonvat Ebenezer N. Yamoah The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell Nature Communications |
| title | The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell |
| title_full | The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell |
| title_fullStr | The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell |
| title_full_unstemmed | The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell |
| title_short | The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell |
| title_sort | piezo channel is a mechano sensitive complex component in the mammalian inner ear hair cell |
| url | https://doi.org/10.1038/s41467-023-44230-x |
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