Metabolic Cost of Dendritic Ca2+ Action Potentials in Layer 5 Pyramidal Neurons

Metabolic Cost of Dendritic Ca2+ Action Potentials in Layer 5 Pyramidal Neurons

Pyramidal neurons consume most signaling-related energy to generate action potentials (APs) and perform synaptic integration. Dendritic Ca2+ spike is an important integration mechanism for coupling inputs from different cortical layers. Our objective was to quantify the metabolic energy associated w...

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Bibliographic Details
Main Authors: Guosheng Yi, Yaqin Fan, Jiang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Neuroscience
Subjects:
Ca2+ action potential
energy cost
dendrites
computational model
pyramidal neuron
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01221/full

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