Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in Vietnamese
Since the emergence and rapid transmission of SARS-CoV-2, numerous scientific reports have searched for the association of host genetic variants with COVID-19, but the data are mostly acquired from Europe. In the current work, we explored the link between host genes (SARS-CoV-2 entry and immune syst...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/10/1884 |
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| author | Vu Phuong Nhung Nguyen Dang Ton Tran Thi Bich Ngoc Ma Thi Huyen Thuong Nguyen Thi Thanh Hai Kim Thi Phuong Oanh Le Thi Thu Hien Pham Ngoc Thach Nong Van Hai Nguyen Hai Ha |
| author_facet | Vu Phuong Nhung Nguyen Dang Ton Tran Thi Bich Ngoc Ma Thi Huyen Thuong Nguyen Thi Thanh Hai Kim Thi Phuong Oanh Le Thi Thu Hien Pham Ngoc Thach Nong Van Hai Nguyen Hai Ha |
| author_sort | Vu Phuong Nhung |
| collection | DOAJ |
| description | Since the emergence and rapid transmission of SARS-CoV-2, numerous scientific reports have searched for the association of host genetic variants with COVID-19, but the data are mostly acquired from Europe. In the current work, we explored the link between host genes (SARS-CoV-2 entry and immune system related to COVID-19 sensitivity/severity) and ABO blood types with COVID-19 from whole-exome data of 200 COVID-19 patients and 100 controls in Vietnam. The O blood type was found to be a protective factor that weakens the worst outcomes of infected individuals. For SARS-CoV-2 susceptibility, rs2229207 (TC genotype, allele C) and rs17860118 (allele T) of <i>IFNAR2</i> increased the risk of infection, but rs139940581 (CT genotype, allele T) of <i>SLC6A20</i> reduced virus sensitivity. For COVID-19 progress, the frequencies of rs4622692 (TG genotype) and rs1048610 (TC genotype) of <i>ADAM17</i> were significantly higher in the moderate group than in the severe/fatal group. The variant rs12329760 (AA genotype) of <i>TMPRSS2</i> was significantly associated with asymptomatic/mild symptoms. Additionally, rs2304255 (CT genotype, allele T) of <i>TYK2</i> and rs2277735 (AG genotype) of <i>DPP9</i> were associated with severe/fatal outcomes. Studies on different populations will give better insights into the pathogenesis, which is ethnic-dependent, and thus decipher the genetic factor’s contribution to mechanisms that predispose people to being more vulnerable to COVID-19. |
| first_indexed | 2024-03-09T20:10:23Z |
| format | Article |
| id | doaj.art-2462b608bf134847a02e810786042376 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T20:10:23Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-2462b608bf134847a02e8107860423762023-11-24T00:16:43ZengMDPI AGGenes2073-44252022-10-011310188410.3390/genes13101884Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in VietnameseVu Phuong Nhung0Nguyen Dang Ton1Tran Thi Bich Ngoc2Ma Thi Huyen Thuong3Nguyen Thi Thanh Hai4Kim Thi Phuong Oanh5Le Thi Thu Hien6Pham Ngoc Thach7Nong Van Hai8Nguyen Hai Ha9Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamInstitute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamInstitute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamInstitute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamNational Hospital for Tropical Disease, Kim Chung, Dong Anh, Hanoi 100000, VietnamInstitute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamInstitute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamNational Hospital for Tropical Disease, Kim Chung, Dong Anh, Hanoi 100000, VietnamInstitute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamInstitute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamSince the emergence and rapid transmission of SARS-CoV-2, numerous scientific reports have searched for the association of host genetic variants with COVID-19, but the data are mostly acquired from Europe. In the current work, we explored the link between host genes (SARS-CoV-2 entry and immune system related to COVID-19 sensitivity/severity) and ABO blood types with COVID-19 from whole-exome data of 200 COVID-19 patients and 100 controls in Vietnam. The O blood type was found to be a protective factor that weakens the worst outcomes of infected individuals. For SARS-CoV-2 susceptibility, rs2229207 (TC genotype, allele C) and rs17860118 (allele T) of <i>IFNAR2</i> increased the risk of infection, but rs139940581 (CT genotype, allele T) of <i>SLC6A20</i> reduced virus sensitivity. For COVID-19 progress, the frequencies of rs4622692 (TG genotype) and rs1048610 (TC genotype) of <i>ADAM17</i> were significantly higher in the moderate group than in the severe/fatal group. The variant rs12329760 (AA genotype) of <i>TMPRSS2</i> was significantly associated with asymptomatic/mild symptoms. Additionally, rs2304255 (CT genotype, allele T) of <i>TYK2</i> and rs2277735 (AG genotype) of <i>DPP9</i> were associated with severe/fatal outcomes. Studies on different populations will give better insights into the pathogenesis, which is ethnic-dependent, and thus decipher the genetic factor’s contribution to mechanisms that predispose people to being more vulnerable to COVID-19.https://www.mdpi.com/2073-4425/13/10/1884SARS-CoV-2COVID-19host genetic variantsABO blood typewhole-exome sequencing |
| spellingShingle | Vu Phuong Nhung Nguyen Dang Ton Tran Thi Bich Ngoc Ma Thi Huyen Thuong Nguyen Thi Thanh Hai Kim Thi Phuong Oanh Le Thi Thu Hien Pham Ngoc Thach Nong Van Hai Nguyen Hai Ha Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in Vietnamese Genes SARS-CoV-2 COVID-19 host genetic variants ABO blood type whole-exome sequencing |
| title | Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in Vietnamese |
| title_full | Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in Vietnamese |
| title_fullStr | Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in Vietnamese |
| title_full_unstemmed | Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in Vietnamese |
| title_short | Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in Vietnamese |
| title_sort | host genetic risk factors associated with covid 19 susceptibility and severity in vietnamese |
| topic | SARS-CoV-2 COVID-19 host genetic variants ABO blood type whole-exome sequencing |
| url | https://www.mdpi.com/2073-4425/13/10/1884 |
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