Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study
Background/objectives: Butyrylcholinesterase (BChE), a liver-derived enzyme that hydrolyzes acylated ghrelin to des-acylated ghrelin, may trigger a potential mechanism responsible for the acute exercise-induced suppression of acylated ghrelin. However, studies examining the effects of an acute bout...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
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| Series: | Journal of Exercise Science & Fitness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1728869X23000618 |
| _version_ | 1797345975787847680 |
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| author | Yibin Li Yusei Tataka Miki Sakazaki Kayoko Kamemoto Chihiro Nagayama Yoshie Yoshikawa Yoshiki Yamada Masashi Miyashita |
| author_facet | Yibin Li Yusei Tataka Miki Sakazaki Kayoko Kamemoto Chihiro Nagayama Yoshie Yoshikawa Yoshiki Yamada Masashi Miyashita |
| author_sort | Yibin Li |
| collection | DOAJ |
| description | Background/objectives: Butyrylcholinesterase (BChE), a liver-derived enzyme that hydrolyzes acylated ghrelin to des-acylated ghrelin, may trigger a potential mechanism responsible for the acute exercise-induced suppression of acylated ghrelin. However, studies examining the effects of an acute bout of high-intensity exercise on BChE and acylated ghrelin have yielded inconsistent findings. This study aimed to examine the acute effects of exercise intensity on BChE, acylated ghrelin and des-acylated ghrelin concentrations in humans. Methods: Fifteen young men (aged 22.7 ± 1.8 years, mean ± standard deviation) completed three, half-day laboratory-based trials (i.e., high-intensity exercise, low-intensity exercise and control), in a random order. In the exercise trials, the participants ran for 60 min (from 09:30 to 10:30) at a speed eliciting 70 % (high-intensity) or 40 % (low-intensity) of their maximum oxygen uptake and then rested for 90 min. In the control trial, participants sat on a chair for the entire trial (from 09:30 to 12:00). Venous blood samples were collected at 09:30, 10:00, 10:30, 11:00, 11:30 and 12:00. Results: The BChE concentration was not altered over time among the three trials. Total acylated and des-acylated ghrelin area under the curve during the first 60 min (i.e., from 0 min to 60 min) of the main trial were lower in the high-intensity exercise trial than in the control (acylated ghrelin, mean difference: 62.6 pg/mL, p < 0.001; des-acylated ghrelin, mean difference: 31.4 pg/mL, p = 0.035) and the low-intensity exercise trial (acylated ghrelin, mean difference: 87.7 pg/mL, p < 0.001; des-acylated ghrelin, mean difference: 43.0 pg/mL, p = 0.042). Conclusion: The findings suggest that BChE may not be involved in the modulation of ghrelin even though lowered acylated ghrelin concentration was observed after high-intensity exercise. |
| first_indexed | 2024-03-08T11:26:33Z |
| format | Article |
| id | doaj.art-24639de2eb644bc0a8708b2a7d28638f |
| institution | Directory Open Access Journal |
| issn | 1728-869X |
| language | English |
| last_indexed | 2024-03-08T11:26:33Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Exercise Science & Fitness |
| spelling | doaj.art-24639de2eb644bc0a8708b2a7d28638f2024-01-26T05:32:32ZengElsevierJournal of Exercise Science & Fitness1728-869X2024-01-012213950Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled studyYibin Li0Yusei Tataka1Miki Sakazaki2Kayoko Kamemoto3Chihiro Nagayama4Yoshie Yoshikawa5Yoshiki Yamada6Masashi Miyashita7Graduate School of Sport Sciences, Waseda University, Saitama, JapanGraduate School of Sport Sciences, Waseda University, Saitama, JapanGraduate School of Sport Sciences, Waseda University, Saitama, JapanWaseda Institute for Sport Sciences, Waseda University, Saitama, JapanGraduate School of Sport Sciences, Waseda University, Saitama, JapanGraduate School of Sport Sciences, Waseda University, Saitama, JapanGraduate School of Sport Sciences, Waseda University, Saitama, JapanFaculty of Sport Sciences, Waseda University, Saitama, Japan; School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, United Kingdom; Department of Sports Science and Physical Education, The Chinese University of Hong Kong, Shatin, Hong Kong; Corresponding author. Waseda University, Faculty of Sport Sciences, 2-579-15 Mikajima, Tokorozawa, Saitama, 359-1192, Japan.Background/objectives: Butyrylcholinesterase (BChE), a liver-derived enzyme that hydrolyzes acylated ghrelin to des-acylated ghrelin, may trigger a potential mechanism responsible for the acute exercise-induced suppression of acylated ghrelin. However, studies examining the effects of an acute bout of high-intensity exercise on BChE and acylated ghrelin have yielded inconsistent findings. This study aimed to examine the acute effects of exercise intensity on BChE, acylated ghrelin and des-acylated ghrelin concentrations in humans. Methods: Fifteen young men (aged 22.7 ± 1.8 years, mean ± standard deviation) completed three, half-day laboratory-based trials (i.e., high-intensity exercise, low-intensity exercise and control), in a random order. In the exercise trials, the participants ran for 60 min (from 09:30 to 10:30) at a speed eliciting 70 % (high-intensity) or 40 % (low-intensity) of their maximum oxygen uptake and then rested for 90 min. In the control trial, participants sat on a chair for the entire trial (from 09:30 to 12:00). Venous blood samples were collected at 09:30, 10:00, 10:30, 11:00, 11:30 and 12:00. Results: The BChE concentration was not altered over time among the three trials. Total acylated and des-acylated ghrelin area under the curve during the first 60 min (i.e., from 0 min to 60 min) of the main trial were lower in the high-intensity exercise trial than in the control (acylated ghrelin, mean difference: 62.6 pg/mL, p < 0.001; des-acylated ghrelin, mean difference: 31.4 pg/mL, p = 0.035) and the low-intensity exercise trial (acylated ghrelin, mean difference: 87.7 pg/mL, p < 0.001; des-acylated ghrelin, mean difference: 43.0 pg/mL, p = 0.042). Conclusion: The findings suggest that BChE may not be involved in the modulation of ghrelin even though lowered acylated ghrelin concentration was observed after high-intensity exercise.http://www.sciencedirect.com/science/article/pii/S1728869X23000618ButyrylcholinesteraseExercise intensityGhrelinRunningSubjective appetite |
| spellingShingle | Yibin Li Yusei Tataka Miki Sakazaki Kayoko Kamemoto Chihiro Nagayama Yoshie Yoshikawa Yoshiki Yamada Masashi Miyashita Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study Journal of Exercise Science & Fitness Butyrylcholinesterase Exercise intensity Ghrelin Running Subjective appetite |
| title | Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study |
| title_full | Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study |
| title_fullStr | Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study |
| title_full_unstemmed | Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study |
| title_short | Acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men: A randomized controlled study |
| title_sort | acute effects of exercise intensity on butyrylcholinesterase and ghrelin in young men a randomized controlled study |
| topic | Butyrylcholinesterase Exercise intensity Ghrelin Running Subjective appetite |
| url | http://www.sciencedirect.com/science/article/pii/S1728869X23000618 |
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