Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses

Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses

Previously, a broadly neutralizing antibody, 3I14, active against groups 1 and 2 influenza A viruses was isolated from human memory B cells and showed protection in mice from lethal viral challenge. Here, Harshbarger and Deming et al. provide the crystal structure of 3I14 Fab in complex with H3, H6,...

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Dettagli Bibliografici
Autori principali: Wayne D. Harshbarger, Derrick Deming, Gordon J. Lockbaum, Nattapol Attatippaholkun, Maliwan Kamkaew, Shurong Hou, Mohan Somasundaran, Jennifer P. Wang, Robert W. Finberg, Quan Karen Zhu, Celia A. Schiffer, Wayne A. Marasco
Natura: Articolo
Lingua:English
Pubblicazione: Nature Portfolio 2021-01-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-020-20879-6

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https://doi.org/10.1038/s41467-020-20879-6

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