Comparison of outcomes between medical and surgical treatment in dogs with prostatic adenocarcinoma: a retrospective study
Abstract Background Prostatic cancer is uncommon in dogs. Dogs with prostatic carcinoma have been reported to have a poor prognosis. Information regarding prognosis with various surgery options as well as prognosis with surgical vs. medical treatment is lacking. This retrospective study compares the...
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s12917-021-03103-5 |
| _version_ | 1819008638421827584 |
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| author | Keigo Iizuka Kumiko Ishigaki Mamiko Seki Takahiro Nagumo Kei Tamura Naoki Sakurai Kazuyuki Terai Kazushi Asano |
| author_facet | Keigo Iizuka Kumiko Ishigaki Mamiko Seki Takahiro Nagumo Kei Tamura Naoki Sakurai Kazuyuki Terai Kazushi Asano |
| author_sort | Keigo Iizuka |
| collection | DOAJ |
| description | Abstract Background Prostatic cancer is uncommon in dogs. Dogs with prostatic carcinoma have been reported to have a poor prognosis. Information regarding prognosis with various surgery options as well as prognosis with surgical vs. medical treatment is lacking. This retrospective study compares the outcomes of medical management to surgical treatment in dogs with prostatic adenocarcinoma and assesses the surgical outcomes of patients who underwent total prostatectomy (TP) and prostatocystectomy (TPC). The medical records of 41 dogs with prostatic adenocarcinoma, between February 2008 and June 2019, were reviewed for information on signalment, clinical signs in the initial evaluation, preoperative diagnostic imaging findings, treatment type (non-surgical or surgical), surgery type, postoperative complications, adjunctive medical therapy, and survival time. The dogs were divided into non-surgical (n = 12) or surgical (n = 29) groups. The surgical group was subdivided into the TP (n = 20) and TPC (n = 9) subgroups. Results Age was not significantly different between the surgical (median 13.1 years [8.4–15.4] years) and the non-surgical groups (median 10.8 [7.7–15.3] years). Body weight (BW) was also not significantly different between the surgical (median 6.8 kg [2.4–34.5 kg]) and non-surgical groups (median 6.4 kg [3.7–9.12 kg]). The overall median survival time (MST) from the initial evaluation was significantly longer in the surgical than in the non-surgical group (337 vs. 90.5 days). The postoperative MST was significantly longer in the TP group than in the TPC subgroup (510 vs. 83 days). As TPC was performed in cases of tumor progression, its postoperative complications were severe, resulting in a shorter MST. Ten (50%) and 6 patients (30%) in the TP subgroup postoperatively showed mild and severe urinary incontinence, respectively, whereas all patients in TPC subgroup did show severe incontinence. Conclusion Results of the study suggest that surgical treatment of prostatic carcinoma results in longer survival times over medical management alone. In particular, TP might be recommended for improving survival time and quality of life in canine prostatic adenocarcinoma that does not infiltrate the bladder. Early detection is key for a survival advantage with surgical treatment. |
| first_indexed | 2024-12-21T00:43:39Z |
| format | Article |
| id | doaj.art-2464915e36f8417d82a4ebcfb4da6f3a |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-21T00:43:39Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-2464915e36f8417d82a4ebcfb4da6f3a2022-12-21T19:21:35ZengBMCBMC Veterinary Research1746-61482022-01-0118111110.1186/s12917-021-03103-5Comparison of outcomes between medical and surgical treatment in dogs with prostatic adenocarcinoma: a retrospective studyKeigo Iizuka0Kumiko Ishigaki1Mamiko Seki2Takahiro Nagumo3Kei Tamura4Naoki Sakurai5Kazuyuki Terai6Kazushi Asano7Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon UniversityLaboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon UniversityLaboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon UniversityLaboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon UniversityLaboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon UniversityLaboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon UniversityLaboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon UniversityLaboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon UniversityAbstract Background Prostatic cancer is uncommon in dogs. Dogs with prostatic carcinoma have been reported to have a poor prognosis. Information regarding prognosis with various surgery options as well as prognosis with surgical vs. medical treatment is lacking. This retrospective study compares the outcomes of medical management to surgical treatment in dogs with prostatic adenocarcinoma and assesses the surgical outcomes of patients who underwent total prostatectomy (TP) and prostatocystectomy (TPC). The medical records of 41 dogs with prostatic adenocarcinoma, between February 2008 and June 2019, were reviewed for information on signalment, clinical signs in the initial evaluation, preoperative diagnostic imaging findings, treatment type (non-surgical or surgical), surgery type, postoperative complications, adjunctive medical therapy, and survival time. The dogs were divided into non-surgical (n = 12) or surgical (n = 29) groups. The surgical group was subdivided into the TP (n = 20) and TPC (n = 9) subgroups. Results Age was not significantly different between the surgical (median 13.1 years [8.4–15.4] years) and the non-surgical groups (median 10.8 [7.7–15.3] years). Body weight (BW) was also not significantly different between the surgical (median 6.8 kg [2.4–34.5 kg]) and non-surgical groups (median 6.4 kg [3.7–9.12 kg]). The overall median survival time (MST) from the initial evaluation was significantly longer in the surgical than in the non-surgical group (337 vs. 90.5 days). The postoperative MST was significantly longer in the TP group than in the TPC subgroup (510 vs. 83 days). As TPC was performed in cases of tumor progression, its postoperative complications were severe, resulting in a shorter MST. Ten (50%) and 6 patients (30%) in the TP subgroup postoperatively showed mild and severe urinary incontinence, respectively, whereas all patients in TPC subgroup did show severe incontinence. Conclusion Results of the study suggest that surgical treatment of prostatic carcinoma results in longer survival times over medical management alone. In particular, TP might be recommended for improving survival time and quality of life in canine prostatic adenocarcinoma that does not infiltrate the bladder. Early detection is key for a survival advantage with surgical treatment.https://doi.org/10.1186/s12917-021-03103-5DogProstatic adenocarcinomaTotal prostatectomyTotal Prostatocystectomy |
| spellingShingle | Keigo Iizuka Kumiko Ishigaki Mamiko Seki Takahiro Nagumo Kei Tamura Naoki Sakurai Kazuyuki Terai Kazushi Asano Comparison of outcomes between medical and surgical treatment in dogs with prostatic adenocarcinoma: a retrospective study BMC Veterinary Research Dog Prostatic adenocarcinoma Total prostatectomy Total Prostatocystectomy |
| title | Comparison of outcomes between medical and surgical treatment in dogs with prostatic adenocarcinoma: a retrospective study |
| title_full | Comparison of outcomes between medical and surgical treatment in dogs with prostatic adenocarcinoma: a retrospective study |
| title_fullStr | Comparison of outcomes between medical and surgical treatment in dogs with prostatic adenocarcinoma: a retrospective study |
| title_full_unstemmed | Comparison of outcomes between medical and surgical treatment in dogs with prostatic adenocarcinoma: a retrospective study |
| title_short | Comparison of outcomes between medical and surgical treatment in dogs with prostatic adenocarcinoma: a retrospective study |
| title_sort | comparison of outcomes between medical and surgical treatment in dogs with prostatic adenocarcinoma a retrospective study |
| topic | Dog Prostatic adenocarcinoma Total prostatectomy Total Prostatocystectomy |
| url | https://doi.org/10.1186/s12917-021-03103-5 |
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