Is there a difference in FDG PET findings of invasive ductal carcinoma of the breast with and without coexisting DCIS?
<strong><em>Objective(s):</em></strong> Studies have reported that invasive ductal carcinoma (IDC) with coexisting ductal carcinoma in situ (DCIS) show lower metastatic potential and recurrence and better overall survival than pure IDC. In this study, we assessed F-18 fluorod...
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| Format: | Article |
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Mashhad University of Medical Sciences
2020-01-01
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| Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
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| Online Access: | http://aojnmb.mums.ac.ir/article_14081_7ad38e1b531b95c22a1addd74d7a6326.pdf |
| _version_ | 1818720171207950336 |
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| author | Ismet Sarikaya Ali Sarikaya Ahmed Albatineh Ebru Tastekin Yavuz Sezer |
| author_facet | Ismet Sarikaya Ali Sarikaya Ahmed Albatineh Ebru Tastekin Yavuz Sezer |
| author_sort | Ismet Sarikaya |
| collection | DOAJ |
| description | <strong><em>Objective(s):</em></strong> Studies have reported that invasive ductal carcinoma (IDC) with coexisting ductal carcinoma in situ (DCIS) show lower metastatic potential and recurrence and better overall survival than pure IDC. In this study, we assessed F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imagesof patients with newly diagnosed IDC to determine if there is any difference in PET findings in IDC-DCIS and pure IDC cases.
<strong><em>Methods: </em></strong>FDG PET/CT images of patients with newly diagnosed IDC of the breast who subsequently underwent breast surgery and had histopathology result in our records were further evaluated. Tumor grade, pathological staging, and presence of DCIS were noted from the histopathology results. Standardized uptake value (SUV) of the primary tumor (SUV<sub>max</sub> and SUL<sub>max</sub>), other hypermetabolic foci in the breast, and ipsilateral normal breast were measured. Presence of axillary and distant metastases was noted.
<strong><em>R</em></strong><strong><em>esults</em></strong><em>: </em>Fifty seven (57) patients with IDC were included. Coexisting DCIS was present in 44 (IDC-DCIS) and not present in 13 (pure IDC) cases. Per histopathology, the primary tumor was unifocal in 33 IDC-DCIS (75%) and 12 pure IDC (92.3%) cases, and multifocal in 11 IDC-DCIS cases (25%), and 1 pure IDC case (7.7%). FDG uptake was multifocal in 20 IDC-DCIS cases (45.5%) and 1 pure IDC case (7.7%), and unifocal in 24 IDC-DCIS (54.5%), and 12 pure IDC (92.3%) cases. There was no significant difference in patient age, size of the primary tumor, SUV<sub>max</sub> and SUL<sub>max</sub> of the primary tumor and SUV<sub>max</sub> of the normal breast in IDC-DCIS and pure IDC cases (p>0.05). Pathology showed axillary metastasis in all 13 pure IDC (100%), and 27 IDC-DCIS (61.4%) cases. PET showed axillary uptake in 25 IDC-DCIS (56.8%), and 8 pure IDC (61.5%) cases, and abnormal/questionable distant uptake in 12 IDC-DCIS cases and 1 pure IDC case.
<strong><em>Conclusion: </em></strong>In our preliminary findings,multifocal breast FDG uptake and multifocal tumor appear to be more common inIDC-DCIS than pure IDC. There is no significant difference in SUV and size of the primary tumor in IDC-DCIS and pure IDC cases. Axillary metastases appear to be more common in pure IDC than IDC-DCIS cases. |
| first_indexed | 2024-12-17T20:18:35Z |
| format | Article |
| id | doaj.art-246749a7c33d4338a5d27ab8ae5f8682 |
| institution | Directory Open Access Journal |
| issn | 2322-5718 2322-5726 |
| language | English |
| last_indexed | 2024-12-17T20:18:35Z |
| publishDate | 2020-01-01 |
| publisher | Mashhad University of Medical Sciences |
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| series | Asia Oceania Journal of Nuclear Medicine and Biology |
| spelling | doaj.art-246749a7c33d4338a5d27ab8ae5f86822022-12-21T21:34:00ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262020-01-0181273510.22038/aojnmb.2019.41658.128414081Is there a difference in FDG PET findings of invasive ductal carcinoma of the breast with and without coexisting DCIS?Ismet Sarikaya0Ali Sarikaya1Ahmed Albatineh2Ebru Tastekin3Yavuz Sezer4Kuwait University, Faculty of Medicine, Department of Nuclear Medicine, KuwaitTrakya University, Faculty of Medicine, Department of Nuclear Medicine, TurkeyKuwait University, Faculty of Medicine, Department of Community Medicine and Behavioral Sciences,KuwaitTrakya University, Faculty of Medicine, Department of Pathology,TurkeyTrakya University, Faculty of Medicine, Department of Surgery, Turkey<strong><em>Objective(s):</em></strong> Studies have reported that invasive ductal carcinoma (IDC) with coexisting ductal carcinoma in situ (DCIS) show lower metastatic potential and recurrence and better overall survival than pure IDC. In this study, we assessed F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imagesof patients with newly diagnosed IDC to determine if there is any difference in PET findings in IDC-DCIS and pure IDC cases. <strong><em>Methods: </em></strong>FDG PET/CT images of patients with newly diagnosed IDC of the breast who subsequently underwent breast surgery and had histopathology result in our records were further evaluated. Tumor grade, pathological staging, and presence of DCIS were noted from the histopathology results. Standardized uptake value (SUV) of the primary tumor (SUV<sub>max</sub> and SUL<sub>max</sub>), other hypermetabolic foci in the breast, and ipsilateral normal breast were measured. Presence of axillary and distant metastases was noted. <strong><em>R</em></strong><strong><em>esults</em></strong><em>: </em>Fifty seven (57) patients with IDC were included. Coexisting DCIS was present in 44 (IDC-DCIS) and not present in 13 (pure IDC) cases. Per histopathology, the primary tumor was unifocal in 33 IDC-DCIS (75%) and 12 pure IDC (92.3%) cases, and multifocal in 11 IDC-DCIS cases (25%), and 1 pure IDC case (7.7%). FDG uptake was multifocal in 20 IDC-DCIS cases (45.5%) and 1 pure IDC case (7.7%), and unifocal in 24 IDC-DCIS (54.5%), and 12 pure IDC (92.3%) cases. There was no significant difference in patient age, size of the primary tumor, SUV<sub>max</sub> and SUL<sub>max</sub> of the primary tumor and SUV<sub>max</sub> of the normal breast in IDC-DCIS and pure IDC cases (p>0.05). Pathology showed axillary metastasis in all 13 pure IDC (100%), and 27 IDC-DCIS (61.4%) cases. PET showed axillary uptake in 25 IDC-DCIS (56.8%), and 8 pure IDC (61.5%) cases, and abnormal/questionable distant uptake in 12 IDC-DCIS cases and 1 pure IDC case. <strong><em>Conclusion: </em></strong>In our preliminary findings,multifocal breast FDG uptake and multifocal tumor appear to be more common inIDC-DCIS than pure IDC. There is no significant difference in SUV and size of the primary tumor in IDC-DCIS and pure IDC cases. Axillary metastases appear to be more common in pure IDC than IDC-DCIS cases.http://aojnmb.mums.ac.ir/article_14081_7ad38e1b531b95c22a1addd74d7a6326.pdffdg petbreast carcinomainvasive ductal carcinomacoexisting dcis |
| spellingShingle | Ismet Sarikaya Ali Sarikaya Ahmed Albatineh Ebru Tastekin Yavuz Sezer Is there a difference in FDG PET findings of invasive ductal carcinoma of the breast with and without coexisting DCIS? Asia Oceania Journal of Nuclear Medicine and Biology fdg pet breast carcinoma invasive ductal carcinoma coexisting dcis |
| title | Is there a difference in FDG PET findings of invasive ductal carcinoma of the breast with and without coexisting DCIS? |
| title_full | Is there a difference in FDG PET findings of invasive ductal carcinoma of the breast with and without coexisting DCIS? |
| title_fullStr | Is there a difference in FDG PET findings of invasive ductal carcinoma of the breast with and without coexisting DCIS? |
| title_full_unstemmed | Is there a difference in FDG PET findings of invasive ductal carcinoma of the breast with and without coexisting DCIS? |
| title_short | Is there a difference in FDG PET findings of invasive ductal carcinoma of the breast with and without coexisting DCIS? |
| title_sort | is there a difference in fdg pet findings of invasive ductal carcinoma of the breast with and without coexisting dcis |
| topic | fdg pet breast carcinoma invasive ductal carcinoma coexisting dcis |
| url | http://aojnmb.mums.ac.ir/article_14081_7ad38e1b531b95c22a1addd74d7a6326.pdf |
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