Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

Summary: A primary goal of the US National Cancer Institute's Ras initiative at the Frederick National Laboratory for Cancer Research is to develop methods to quantify RAS signaling to facilitate development of novel cancer therapeutics. We use targeted proteomics technologies to develop a comm...

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Bibliographic Details
Main Authors: Jeffrey R. Whiteaker, Kanika Sharma, Melissa A. Hoffman, Eric Kuhn, Lei Zhao, Alexandra R. Cocco, Regine M. Schoenherr, Jacob J. Kennedy, Ulianna Voytovich, Chenwei Lin, Bin Fang, Kiah Bowers, Gordon Whiteley, Simona Colantonio, William Bocik, Rhonda Roberts, Tara Hiltke, Emily Boja, Henry Rodriguez, Frank McCormick, Matthew Holderfield, Steven A. Carr, John M. Koomen, Amanda G. Paulovich
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports: Methods
Subjects:
cancer signaling
immuno-MRM
assay resource
quantitative proteomics
pharmacodynamics
targeted therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2667237521000151

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