Prognostic significance of systemic inflammatory markers in esophageal cancer: Systematic review and meta‐analysis
Abstract Aim Impact of several immune‐inflammatory markers on long‐term outcome has been reported in various malignancies. The aim of the present study was to evaluate through a meta‐analysis the oncological outcome of immune‐inflammatory markers, such as neutrophil to lymphocyte ratio (NLR), platel...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Annals of Gastroenterological Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ags3.12294 |
| _version_ | 1824030810342162432 |
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| author | Yusuke Ishibashi Hironori Tsujimoto Yoshihisa Yaguchi Yoji Kishi Hideki Ueno |
| author_facet | Yusuke Ishibashi Hironori Tsujimoto Yoshihisa Yaguchi Yoji Kishi Hideki Ueno |
| author_sort | Yusuke Ishibashi |
| collection | DOAJ |
| description | Abstract Aim Impact of several immune‐inflammatory markers on long‐term outcome has been reported in various malignancies. The aim of the present study was to evaluate through a meta‐analysis the oncological outcome of immune‐inflammatory markers, such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and C‐reactive protein to albumin ratio (CAR) in esophageal cancer. Methods A systematic electronic search for relevant studies was carried out in PubMed, Cochrane library, Embase, and Google scholar. Meta‐analysis was done using hazard ratio (HR) and 95% confidence interval (CI) as effect measures. A systematic review and meta‐analysis were undertaken according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses protocol. P‐values <.01 were considered statistically significant. Results A total of 10 retrospective articles (n = 4551) were included in this study. Synthesized results showed that higher NLR and CAR were significantly associated with poor overall survival (HR 1.47, 95% CI = 1.32‐1.63, P < .00001) and HR 1.88, 95% CI = 1.28‐2.77, P < .001, respectively). On the contrary, PLR was not a prognostic factor in our analysis (HR 1.25, 95% CI = 1.01‐1.54, P < .01). Elevated NLR, PLR, and CAR were strongly associated with a higher T stage (HR 2.28, 95% CI = 1.67‐3.11; HR 1.57, 95% CI = 1.29‐1.90; HR 1.76, 95% CI = 1.16‐2.67, respectively). Begg’s funnel plots identified significant publication bias in NLR, but not in PLR and CAR. Conclusion NLR and CAR represent useful guides for the management of esophageal cancer, although publication bias should be considered. Further prospective studies are needed to confirm the results of the present study. |
| first_indexed | 2024-12-19T18:45:44Z |
| format | Article |
| id | doaj.art-2468123581134ced87b96b80bb42e91f |
| institution | Directory Open Access Journal |
| issn | 2475-0328 |
| language | English |
| last_indexed | 2024-12-19T18:45:44Z |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj.art-2468123581134ced87b96b80bb42e91f2022-12-21T20:10:06ZengWileyAnnals of Gastroenterological Surgery2475-03282020-01-0141566310.1002/ags3.12294Prognostic significance of systemic inflammatory markers in esophageal cancer: Systematic review and meta‐analysisYusuke Ishibashi0Hironori Tsujimoto1Yoshihisa Yaguchi2Yoji Kishi3Hideki Ueno4Department of Surgery National Defense Medical College Tokorozawa JapanDepartment of Surgery National Defense Medical College Tokorozawa JapanDepartment of Surgery National Defense Medical College Tokorozawa JapanDepartment of Surgery National Defense Medical College Tokorozawa JapanDepartment of Surgery National Defense Medical College Tokorozawa JapanAbstract Aim Impact of several immune‐inflammatory markers on long‐term outcome has been reported in various malignancies. The aim of the present study was to evaluate through a meta‐analysis the oncological outcome of immune‐inflammatory markers, such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and C‐reactive protein to albumin ratio (CAR) in esophageal cancer. Methods A systematic electronic search for relevant studies was carried out in PubMed, Cochrane library, Embase, and Google scholar. Meta‐analysis was done using hazard ratio (HR) and 95% confidence interval (CI) as effect measures. A systematic review and meta‐analysis were undertaken according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses protocol. P‐values <.01 were considered statistically significant. Results A total of 10 retrospective articles (n = 4551) were included in this study. Synthesized results showed that higher NLR and CAR were significantly associated with poor overall survival (HR 1.47, 95% CI = 1.32‐1.63, P < .00001) and HR 1.88, 95% CI = 1.28‐2.77, P < .001, respectively). On the contrary, PLR was not a prognostic factor in our analysis (HR 1.25, 95% CI = 1.01‐1.54, P < .01). Elevated NLR, PLR, and CAR were strongly associated with a higher T stage (HR 2.28, 95% CI = 1.67‐3.11; HR 1.57, 95% CI = 1.29‐1.90; HR 1.76, 95% CI = 1.16‐2.67, respectively). Begg’s funnel plots identified significant publication bias in NLR, but not in PLR and CAR. Conclusion NLR and CAR represent useful guides for the management of esophageal cancer, although publication bias should be considered. Further prospective studies are needed to confirm the results of the present study.https://doi.org/10.1002/ags3.12294C‐reactive protein to albumin ratioesophageal cancerneutrophil to lymphocyte ratioplatelet to lymphocyte ratioprognostic factor |
| spellingShingle | Yusuke Ishibashi Hironori Tsujimoto Yoshihisa Yaguchi Yoji Kishi Hideki Ueno Prognostic significance of systemic inflammatory markers in esophageal cancer: Systematic review and meta‐analysis Annals of Gastroenterological Surgery C‐reactive protein to albumin ratio esophageal cancer neutrophil to lymphocyte ratio platelet to lymphocyte ratio prognostic factor |
| title | Prognostic significance of systemic inflammatory markers in esophageal cancer: Systematic review and meta‐analysis |
| title_full | Prognostic significance of systemic inflammatory markers in esophageal cancer: Systematic review and meta‐analysis |
| title_fullStr | Prognostic significance of systemic inflammatory markers in esophageal cancer: Systematic review and meta‐analysis |
| title_full_unstemmed | Prognostic significance of systemic inflammatory markers in esophageal cancer: Systematic review and meta‐analysis |
| title_short | Prognostic significance of systemic inflammatory markers in esophageal cancer: Systematic review and meta‐analysis |
| title_sort | prognostic significance of systemic inflammatory markers in esophageal cancer systematic review and meta analysis |
| topic | C‐reactive protein to albumin ratio esophageal cancer neutrophil to lymphocyte ratio platelet to lymphocyte ratio prognostic factor |
| url | https://doi.org/10.1002/ags3.12294 |
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