Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis
Abstract End‐stage kidney disease (ESKD) is associated with increased arterial stiffness and cognitive impairment. Cognitive decline is accelerated in ESKD patients on hemodialysis and may result from repeatedly inappropriate cerebral blood flow (CBF). The aim of this study was to examine the acute...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15595 |
| _version_ | 1797397596531064832 |
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| author | Mathilde Paré Hasan Obeid Lawrence Labrecque Audrey Drapeau Patrice Brassard Mohsen Agharazii |
| author_facet | Mathilde Paré Hasan Obeid Lawrence Labrecque Audrey Drapeau Patrice Brassard Mohsen Agharazii |
| author_sort | Mathilde Paré |
| collection | DOAJ |
| description | Abstract End‐stage kidney disease (ESKD) is associated with increased arterial stiffness and cognitive impairment. Cognitive decline is accelerated in ESKD patients on hemodialysis and may result from repeatedly inappropriate cerebral blood flow (CBF). The aim of this study was to examine the acute effect of hemodialysis on pulsatile components of CBF and their relation to acute changes in arterial stiffness. In eight participants (age: 63 ± 18 years, men: 5), CBF was estimated using middle cerebral artery blood velocity (MCAv) assessed with transcranial Doppler ultrasound before, during, and after a single hemodialysis session. Brachial and central blood pressure, along with estimated aortic stiffness (eAoPWV) were measured using an oscillometric device. Arterial stiffness from heart to MCA was measured as the pulse arrival time (PAT) between electrocardiogram (ECG) and transcranial Doppler ultrasound waveforms (cerebral PAT). During hemodialysis, there was a significant reduction in mean MCAv (−3.2 cm/s, p < 0.001), and systolic MCAv (−13.0 cm/s, p < 0.001). While baseline eAoPWV (9.25 ± 0.80 m/s) did not significantly change during hemodialysis, cerebral PAT increased significantly (+0.027 , p < 0.001) and was associated with reduced pulsatile components of MCAv. This study shows that hemodialysis acutely reduces stiffness of arteries perfusing the brain along with pulsatile components of blood velocity. |
| first_indexed | 2024-03-09T01:12:24Z |
| format | Article |
| id | doaj.art-246a44cc651048b68024f0e38e844e3b |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-09T01:12:24Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-246a44cc651048b68024f0e38e844e3b2023-12-11T03:15:45ZengWileyPhysiological Reports2051-817X2023-02-01114n/an/a10.14814/phy2.15595Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysisMathilde Paré0Hasan Obeid1Lawrence Labrecque2Audrey Drapeau3Patrice Brassard4Mohsen Agharazii5CHU de Québec Research Center, L'Hôtel‐Dieu de Québec Hospital Québec City Quebec CanadaCHU de Québec Research Center, L'Hôtel‐Dieu de Québec Hospital Québec City Quebec CanadaResearch Center of the Institute Universitaire de Cardiologie et de Pneumologie de Québec Québec City Quebec CanadaResearch Center of the Institute Universitaire de Cardiologie et de Pneumologie de Québec Québec City Quebec CanadaResearch Center of the Institute Universitaire de Cardiologie et de Pneumologie de Québec Québec City Quebec CanadaCHU de Québec Research Center, L'Hôtel‐Dieu de Québec Hospital Québec City Quebec CanadaAbstract End‐stage kidney disease (ESKD) is associated with increased arterial stiffness and cognitive impairment. Cognitive decline is accelerated in ESKD patients on hemodialysis and may result from repeatedly inappropriate cerebral blood flow (CBF). The aim of this study was to examine the acute effect of hemodialysis on pulsatile components of CBF and their relation to acute changes in arterial stiffness. In eight participants (age: 63 ± 18 years, men: 5), CBF was estimated using middle cerebral artery blood velocity (MCAv) assessed with transcranial Doppler ultrasound before, during, and after a single hemodialysis session. Brachial and central blood pressure, along with estimated aortic stiffness (eAoPWV) were measured using an oscillometric device. Arterial stiffness from heart to MCA was measured as the pulse arrival time (PAT) between electrocardiogram (ECG) and transcranial Doppler ultrasound waveforms (cerebral PAT). During hemodialysis, there was a significant reduction in mean MCAv (−3.2 cm/s, p < 0.001), and systolic MCAv (−13.0 cm/s, p < 0.001). While baseline eAoPWV (9.25 ± 0.80 m/s) did not significantly change during hemodialysis, cerebral PAT increased significantly (+0.027 , p < 0.001) and was associated with reduced pulsatile components of MCAv. This study shows that hemodialysis acutely reduces stiffness of arteries perfusing the brain along with pulsatile components of blood velocity.https://doi.org/10.14814/phy2.15595arterial stiffnesscerebral pulsatility indexend‐stage kidney diseasehemodialysismiddle cerebral artery mean blood velocitypulse wave velocity |
| spellingShingle | Mathilde Paré Hasan Obeid Lawrence Labrecque Audrey Drapeau Patrice Brassard Mohsen Agharazii Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis Physiological Reports arterial stiffness cerebral pulsatility index end‐stage kidney disease hemodialysis middle cerebral artery mean blood velocity pulse wave velocity |
| title | Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis |
| title_full | Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis |
| title_fullStr | Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis |
| title_full_unstemmed | Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis |
| title_short | Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis |
| title_sort | cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis |
| topic | arterial stiffness cerebral pulsatility index end‐stage kidney disease hemodialysis middle cerebral artery mean blood velocity pulse wave velocity |
| url | https://doi.org/10.14814/phy2.15595 |
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